Detection of CD5 in B-cell chronic lymphoproliferative diseases by flow cytometry: a strong expression in B-cell chronic lymphocytic leukemia

• Autor(a) principal: Cavalcanti Júnior,Geraldo Barroso
• Data de Publicação: 2005
• Outros Autores: Sales,Valeria Soraya de Farias, Cavalcanti e Silva,Dany Geraldo Kramer, Lopes,Maria Cleide de Araújo, Paiva,Aldair de Souza, Fonseca,Henrique Eduardo Macedo da, Nascimento Júnior,Francisco Fernandes do, Fernandes,Maria Zélia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000700011
• topic: CD5; B cell; Chronic lymphocytic leukemia; B-cell prolymphocytic leukemia; Hairy cell; Mantle cell lymphoma

PURPOSE: CD5 is a T cell marker, aberrantly express in B cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL). Other chronic B cell malignancies including hairy cell leukemia (HCL) and B cell prolymphocytic leukemia (B-PLL) are CD5 negative or express this antigen in a weak way. In this study, CD5 expression was investigated in leukemic cells from 42 patients with chronic B cell lymphoproliferative disease. METHODS: We studied the CD5 expression in leukemic cells from 42 patients with chronic B-cell malignancies by flow cytometry. Demographic features such as age, sex and clinical date were also analyzed. RESULTS: There were 22 males and 20 females. The immunophenotyping showed that 35 cases were B-CLL, 3 B-PLL and HCL and one patient was MCL. CD5 expression was present in all B-CLL and MCL. Low expression of CD5 was observed in one patient with B-PLL and negative in all cases of HCL. CONCLUSION: Our date demonstrated that CD5 expression can help distinguish among B-CLL from HCL and B-PLL, but is similar expressed in MCL.