Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021001000208 |
Resumo: | ABSTRACT Purpose: To evaluate the morphological effects of a low-protein diet during maternal lactation on the offspring’s thoracic aorta. Methods: Two female Wistar rats were mated with male of the same species at 4 months of age. Until the birth of the pups, all animals received commercial rat chow. After giving birth, the puerperal females were divided into two groups and adjusted the litter to five puppies per group: a control group that received commercial feed, and an experimental group whose diet included the same amount of calories, but 8% lower protein content. All animals’ masses were measured throughout the lactation period, and the pups were euthanized after weaning at 21 days of age. The thoracic aorta was removed, histologically processed and stained with Weigert’s resorcin-fuchsin for histomorphometric analysis of tunica media thickness. Results: Although both groups were born with similar body mass, during the 21 days of lactation the restricted protein group gained only 39% of the body mass of the control group. Histomorphometric analysis revealed that the restricted protein group had a significantly lower mean tunica media thickness than the control group. Conclusions: A low-protein diet for nursing mothers influences mass gain and aortic tunica media thickness in their offspring. |
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Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pupsProtein DeficiencyAorta, ThoracicMalnutritionRatsABSTRACT Purpose: To evaluate the morphological effects of a low-protein diet during maternal lactation on the offspring’s thoracic aorta. Methods: Two female Wistar rats were mated with male of the same species at 4 months of age. Until the birth of the pups, all animals received commercial rat chow. After giving birth, the puerperal females were divided into two groups and adjusted the litter to five puppies per group: a control group that received commercial feed, and an experimental group whose diet included the same amount of calories, but 8% lower protein content. All animals’ masses were measured throughout the lactation period, and the pups were euthanized after weaning at 21 days of age. The thoracic aorta was removed, histologically processed and stained with Weigert’s resorcin-fuchsin for histomorphometric analysis of tunica media thickness. Results: Although both groups were born with similar body mass, during the 21 days of lactation the restricted protein group gained only 39% of the body mass of the control group. Histomorphometric analysis revealed that the restricted protein group had a significantly lower mean tunica media thickness than the control group. Conclusions: A low-protein diet for nursing mothers influences mass gain and aortic tunica media thickness in their offspring.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021001000208Acta Cirúrgica Brasileira v.36 n.10 2021reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/acb361008info:eu-repo/semantics/openAccessCarvalho,Ronaldo MiguelFerreira,Isabeliza Maria do Espírito Santo RangelMiranda Jr,Faustoeng2021-11-24T00:00:00Zoai:scielo:S0102-86502021001000208Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2021-11-24T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups |
title |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups |
spellingShingle |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups Carvalho,Ronaldo Miguel Protein Deficiency Aorta, Thoracic Malnutrition Rats |
title_short |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups |
title_full |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups |
title_fullStr |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups |
title_full_unstemmed |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups |
title_sort |
Protein malnutrition during lactation affects thoracic aortic tunica media thickness in Wistar rat pups |
author |
Carvalho,Ronaldo Miguel |
author_facet |
Carvalho,Ronaldo Miguel Ferreira,Isabeliza Maria do Espírito Santo Rangel Miranda Jr,Fausto |
author_role |
author |
author2 |
Ferreira,Isabeliza Maria do Espírito Santo Rangel Miranda Jr,Fausto |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Carvalho,Ronaldo Miguel Ferreira,Isabeliza Maria do Espírito Santo Rangel Miranda Jr,Fausto |
dc.subject.por.fl_str_mv |
Protein Deficiency Aorta, Thoracic Malnutrition Rats |
topic |
Protein Deficiency Aorta, Thoracic Malnutrition Rats |
description |
ABSTRACT Purpose: To evaluate the morphological effects of a low-protein diet during maternal lactation on the offspring’s thoracic aorta. Methods: Two female Wistar rats were mated with male of the same species at 4 months of age. Until the birth of the pups, all animals received commercial rat chow. After giving birth, the puerperal females were divided into two groups and adjusted the litter to five puppies per group: a control group that received commercial feed, and an experimental group whose diet included the same amount of calories, but 8% lower protein content. All animals’ masses were measured throughout the lactation period, and the pups were euthanized after weaning at 21 days of age. The thoracic aorta was removed, histologically processed and stained with Weigert’s resorcin-fuchsin for histomorphometric analysis of tunica media thickness. Results: Although both groups were born with similar body mass, during the 21 days of lactation the restricted protein group gained only 39% of the body mass of the control group. Histomorphometric analysis revealed that the restricted protein group had a significantly lower mean tunica media thickness than the control group. Conclusions: A low-protein diet for nursing mothers influences mass gain and aortic tunica media thickness in their offspring. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021001000208 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021001000208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/acb361008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.36 n.10 2021 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
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1752126446318387200 |