Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats

Detalhes bibliográficos
Autor(a) principal: Penhavel,Maria Vitória Carmo
Data de Publicação: 2013
Outros Autores: Nascimento,Victor Henrique Tavares, Durães,Eliana Ferreira Ribeiro, Carneiro,Fabiana Pirani, Sousa,João Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003
Resumo: PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
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spelling Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of ratsWound HealingCarbon DioxideSkinRatsPURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003Acta Cirúrgica Brasileira v.28 n.5 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013000500003info:eu-repo/semantics/openAccessPenhavel,Maria Vitória CarmoNascimento,Victor Henrique TavaresDurães,Eliana Ferreira RibeiroCarneiro,Fabiana PiraniSousa,João Batista deeng2013-05-20T00:00:00Zoai:scielo:S0102-86502013000500003Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-05-20T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
spellingShingle Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
Penhavel,Maria Vitória Carmo
Wound Healing
Carbon Dioxide
Skin
Rats
title_short Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_full Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_fullStr Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_full_unstemmed Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_sort Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
author Penhavel,Maria Vitória Carmo
author_facet Penhavel,Maria Vitória Carmo
Nascimento,Victor Henrique Tavares
Durães,Eliana Ferreira Ribeiro
Carneiro,Fabiana Pirani
Sousa,João Batista de
author_role author
author2 Nascimento,Victor Henrique Tavares
Durães,Eliana Ferreira Ribeiro
Carneiro,Fabiana Pirani
Sousa,João Batista de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Penhavel,Maria Vitória Carmo
Nascimento,Victor Henrique Tavares
Durães,Eliana Ferreira Ribeiro
Carneiro,Fabiana Pirani
Sousa,João Batista de
dc.subject.por.fl_str_mv Wound Healing
Carbon Dioxide
Skin
Rats
topic Wound Healing
Carbon Dioxide
Skin
Rats
description PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502013000500003
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dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.28 n.5 2013
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
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reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
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