Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction

Detalhes bibliográficos
Autor(a) principal: Lessa,Jorge Fernando Rebouças
Data de Publicação: 2011
Outros Autores: Rangel,Leonardo Siqueira, Costa Junior,Nilton José de Almeida, Silva,Orlando Castro e, Cruz,Carlos Augusto Teixeira da, Sousa,João Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800013
Resumo: PURPOSE: To study the influence of albumin on changes of liver function in the extrahepatic biliary obstruction through an experimental model in rats. METHODS: Sixty rats were divided into four groups: Group C (Control): 6 animals. Group M (Fictitious Operation): 18 rats underwent laparotomy and handling of the bile ducts; Groups O (extrahepatic biliary obstruction) and A (Treated with 2% albumin): 18 animals in each group underwent ligation of the ductus liver; The animals in groups M, O and A were divided into three subgroups of 6 animals each to be killed in the 7, 14 and 21 days postoperative (POD). Blood was drawn for determination of total bilirubin (TB), indirect bilirubin (IB), direct bilirubin (DB), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). RESULTS: On POD 7, BI levels were 4.5 mg / dl in group O and 2.1 mg / dl in group A (p = 0.025). On the 14th POD, the levels of PA were 1185.2 U / l in the group and O 458.3 U / l in group A (p = 0.004). ALT levels were 101.7 U / l in the group O and 75.7 U / l in group A (= 0.037). On POD 21, the levels of ALP were 1069.5 U / l in the group O and 468.3 U / l in group A (p = 0, 004). CONCLUSION: The administration of albumin reduced the serum levels of bilirubin in the 7th day of supplementation
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spelling Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstructionCholestasis, ExtrahepaticAlbuminEnzymesLiverRatsPURPOSE: To study the influence of albumin on changes of liver function in the extrahepatic biliary obstruction through an experimental model in rats. METHODS: Sixty rats were divided into four groups: Group C (Control): 6 animals. Group M (Fictitious Operation): 18 rats underwent laparotomy and handling of the bile ducts; Groups O (extrahepatic biliary obstruction) and A (Treated with 2% albumin): 18 animals in each group underwent ligation of the ductus liver; The animals in groups M, O and A were divided into three subgroups of 6 animals each to be killed in the 7, 14 and 21 days postoperative (POD). Blood was drawn for determination of total bilirubin (TB), indirect bilirubin (IB), direct bilirubin (DB), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). RESULTS: On POD 7, BI levels were 4.5 mg / dl in group O and 2.1 mg / dl in group A (p = 0.025). On the 14th POD, the levels of PA were 1185.2 U / l in the group and O 458.3 U / l in group A (p = 0.004). ALT levels were 101.7 U / l in the group O and 75.7 U / l in group A (= 0.037). On POD 21, the levels of ALP were 1069.5 U / l in the group O and 468.3 U / l in group A (p = 0, 004). CONCLUSION: The administration of albumin reduced the serum levels of bilirubin in the 7th day of supplementationSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800013Acta Cirúrgica Brasileira v.26 suppl.2 2011reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502011000800013info:eu-repo/semantics/openAccessLessa,Jorge Fernando RebouçasRangel,Leonardo SiqueiraCosta Junior,Nilton José de AlmeidaSilva,Orlando Castro eCruz,Carlos Augusto Teixeira daSousa,João Batista deeng2011-10-24T00:00:00Zoai:scielo:S0102-86502011000800013Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2011-10-24T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
title Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
spellingShingle Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
Lessa,Jorge Fernando Rebouças
Cholestasis, Extrahepatic
Albumin
Enzymes
Liver
Rats
title_short Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
title_full Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
title_fullStr Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
title_full_unstemmed Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
title_sort Effects of albumin administration in serum liver enzymes of rats in the presence of extrahepatic biliary obstruction
author Lessa,Jorge Fernando Rebouças
author_facet Lessa,Jorge Fernando Rebouças
Rangel,Leonardo Siqueira
Costa Junior,Nilton José de Almeida
Silva,Orlando Castro e
Cruz,Carlos Augusto Teixeira da
Sousa,João Batista de
author_role author
author2 Rangel,Leonardo Siqueira
Costa Junior,Nilton José de Almeida
Silva,Orlando Castro e
Cruz,Carlos Augusto Teixeira da
Sousa,João Batista de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lessa,Jorge Fernando Rebouças
Rangel,Leonardo Siqueira
Costa Junior,Nilton José de Almeida
Silva,Orlando Castro e
Cruz,Carlos Augusto Teixeira da
Sousa,João Batista de
dc.subject.por.fl_str_mv Cholestasis, Extrahepatic
Albumin
Enzymes
Liver
Rats
topic Cholestasis, Extrahepatic
Albumin
Enzymes
Liver
Rats
description PURPOSE: To study the influence of albumin on changes of liver function in the extrahepatic biliary obstruction through an experimental model in rats. METHODS: Sixty rats were divided into four groups: Group C (Control): 6 animals. Group M (Fictitious Operation): 18 rats underwent laparotomy and handling of the bile ducts; Groups O (extrahepatic biliary obstruction) and A (Treated with 2% albumin): 18 animals in each group underwent ligation of the ductus liver; The animals in groups M, O and A were divided into three subgroups of 6 animals each to be killed in the 7, 14 and 21 days postoperative (POD). Blood was drawn for determination of total bilirubin (TB), indirect bilirubin (IB), direct bilirubin (DB), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). RESULTS: On POD 7, BI levels were 4.5 mg / dl in group O and 2.1 mg / dl in group A (p = 0.025). On the 14th POD, the levels of PA were 1185.2 U / l in the group and O 458.3 U / l in group A (p = 0.004). ALT levels were 101.7 U / l in the group O and 75.7 U / l in group A (= 0.037). On POD 21, the levels of ALP were 1069.5 U / l in the group O and 468.3 U / l in group A (p = 0, 004). CONCLUSION: The administration of albumin reduced the serum levels of bilirubin in the 7th day of supplementation
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502011000800013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.26 suppl.2 2011
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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