Influence of arterial hypertension treated with losartan on skin healing in rats

Detalhes bibliográficos
Autor(a) principal: Biondo-Simões,Maria de Lourdes Pessole
Data de Publicação: 2006
Outros Autores: Zazula,Ana Denise, Gomes,Ariana Braga, Poncio,Caroline, Torres,Luiz Fernando Bleggi, Borsato,Karin Sodatelli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000300005
Resumo: PURPOSE: To evaluate the role of Losartan in skin healing repair. METHODS: One hundred and eleven male Wistar rats were distributed into four groups, at random. Group I (n=31) underwent a laparotomy to induce hypertension by stenosis of the left renal artery, and 48 hours later it received Losartan (10 mg/Kg) daily. Group II (n=30) went through the same procedure and received isotonic saline solution. Group III (n=30) underwent a simulated laparotomy. Group IV (n=20) to confirm the induced hypertension method. Ketamine and Xylazin anesthesia was used in every painful/stressful procedure. After 15 days, skin healing repair was studied by a dorsal midline skin incision and second layer-skin incision in groups I, II and III, that was sutured in one layer with 4-0 nylon suture. Samples of the dorsal wall scar were taken 4, 7 and 14 days after the last procedure, and sent to strength and displacement analysis and histological preparation. RESULTS: By the 4th and 7th days of the analysis, group II scars showed to be less resistant than group III scars (p<0,05). The total amount of collagen was higher in group III on the three studied periods. The percentage occupied by total collagen in the wound area, on the 14th day, was lower in group I, due to its lower percentage of type I collagen CONCLUSION: Scars treated with Losartan were initially less resistant and had a lower collagen deposition.
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spelling Influence of arterial hypertension treated with losartan on skin healing in ratsWound healingCollagenLosartanPURPOSE: To evaluate the role of Losartan in skin healing repair. METHODS: One hundred and eleven male Wistar rats were distributed into four groups, at random. Group I (n=31) underwent a laparotomy to induce hypertension by stenosis of the left renal artery, and 48 hours later it received Losartan (10 mg/Kg) daily. Group II (n=30) went through the same procedure and received isotonic saline solution. Group III (n=30) underwent a simulated laparotomy. Group IV (n=20) to confirm the induced hypertension method. Ketamine and Xylazin anesthesia was used in every painful/stressful procedure. After 15 days, skin healing repair was studied by a dorsal midline skin incision and second layer-skin incision in groups I, II and III, that was sutured in one layer with 4-0 nylon suture. Samples of the dorsal wall scar were taken 4, 7 and 14 days after the last procedure, and sent to strength and displacement analysis and histological preparation. RESULTS: By the 4th and 7th days of the analysis, group II scars showed to be less resistant than group III scars (p<0,05). The total amount of collagen was higher in group III on the three studied periods. The percentage occupied by total collagen in the wound area, on the 14th day, was lower in group I, due to its lower percentage of type I collagen CONCLUSION: Scars treated with Losartan were initially less resistant and had a lower collagen deposition.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000300005Acta Cirúrgica Brasileira v.21 n.3 2006reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502006000300005info:eu-repo/semantics/openAccessBiondo-Simões,Maria de Lourdes PessoleZazula,Ana DeniseGomes,Ariana BragaPoncio,CarolineTorres,Luiz Fernando BleggiBorsato,Karin Sodatellieng2006-05-26T00:00:00Zoai:scielo:S0102-86502006000300005Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2006-05-26T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Influence of arterial hypertension treated with losartan on skin healing in rats
title Influence of arterial hypertension treated with losartan on skin healing in rats
spellingShingle Influence of arterial hypertension treated with losartan on skin healing in rats
Biondo-Simões,Maria de Lourdes Pessole
Wound healing
Collagen
Losartan
title_short Influence of arterial hypertension treated with losartan on skin healing in rats
title_full Influence of arterial hypertension treated with losartan on skin healing in rats
title_fullStr Influence of arterial hypertension treated with losartan on skin healing in rats
title_full_unstemmed Influence of arterial hypertension treated with losartan on skin healing in rats
title_sort Influence of arterial hypertension treated with losartan on skin healing in rats
author Biondo-Simões,Maria de Lourdes Pessole
author_facet Biondo-Simões,Maria de Lourdes Pessole
Zazula,Ana Denise
Gomes,Ariana Braga
Poncio,Caroline
Torres,Luiz Fernando Bleggi
Borsato,Karin Sodatelli
author_role author
author2 Zazula,Ana Denise
Gomes,Ariana Braga
Poncio,Caroline
Torres,Luiz Fernando Bleggi
Borsato,Karin Sodatelli
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Biondo-Simões,Maria de Lourdes Pessole
Zazula,Ana Denise
Gomes,Ariana Braga
Poncio,Caroline
Torres,Luiz Fernando Bleggi
Borsato,Karin Sodatelli
dc.subject.por.fl_str_mv Wound healing
Collagen
Losartan
topic Wound healing
Collagen
Losartan
description PURPOSE: To evaluate the role of Losartan in skin healing repair. METHODS: One hundred and eleven male Wistar rats were distributed into four groups, at random. Group I (n=31) underwent a laparotomy to induce hypertension by stenosis of the left renal artery, and 48 hours later it received Losartan (10 mg/Kg) daily. Group II (n=30) went through the same procedure and received isotonic saline solution. Group III (n=30) underwent a simulated laparotomy. Group IV (n=20) to confirm the induced hypertension method. Ketamine and Xylazin anesthesia was used in every painful/stressful procedure. After 15 days, skin healing repair was studied by a dorsal midline skin incision and second layer-skin incision in groups I, II and III, that was sutured in one layer with 4-0 nylon suture. Samples of the dorsal wall scar were taken 4, 7 and 14 days after the last procedure, and sent to strength and displacement analysis and histological preparation. RESULTS: By the 4th and 7th days of the analysis, group II scars showed to be less resistant than group III scars (p<0,05). The total amount of collagen was higher in group III on the three studied periods. The percentage occupied by total collagen in the wound area, on the 14th day, was lower in group I, due to its lower percentage of type I collagen CONCLUSION: Scars treated with Losartan were initially less resistant and had a lower collagen deposition.
publishDate 2006
dc.date.none.fl_str_mv 2006-06-01
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dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000300005
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S0102-86502006000300005
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.21 n.3 2006
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
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reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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