Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000700515 |
Resumo: | Abstract Purpose: To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy. Methods: Forty rats were subjected to 70% hepatectomy and then ~106 mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted. Results: No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p<.05). Conclusions: Mesenchymal stem-cell therapy did not improve liver regeneration rate 3 d or 5 d after 70% hepatectomy in rats. Likewise, the therapy appeared not to affect liver function, proliferative index, or number of mitoses significantly. |
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Acta Cirúrgica Brasileira (Online) |
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Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?Mesenchymal Stem Cell TransplantationLiver RegenerationHepatectomyCell- and Tissue-Based TherapyRatsAbstract Purpose: To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy. Methods: Forty rats were subjected to 70% hepatectomy and then ~106 mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted. Results: No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p<.05). Conclusions: Mesenchymal stem-cell therapy did not improve liver regeneration rate 3 d or 5 d after 70% hepatectomy in rats. Likewise, the therapy appeared not to affect liver function, proliferative index, or number of mitoses significantly.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000700515Acta Cirúrgica Brasileira v.32 n.7 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170070000002info:eu-repo/semantics/openAccessAlves,Ana Karina SoaresLanzoni,ValériaFuziy,Rogério AokiFranco,Rita Maria Aparecida Monteiro MouraMaeda,Carlos ToshinoriLopes Filho,Gaspar de JesusLinhares,Marcelo Mouraeng2017-08-02T00:00:00Zoai:scielo:S0102-86502017000700515Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-08-02T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? |
title |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? |
spellingShingle |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? Alves,Ana Karina Soares Mesenchymal Stem Cell Transplantation Liver Regeneration Hepatectomy Cell- and Tissue-Based Therapy Rats |
title_short |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? |
title_full |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? |
title_fullStr |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? |
title_full_unstemmed |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? |
title_sort |
Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy? |
author |
Alves,Ana Karina Soares |
author_facet |
Alves,Ana Karina Soares Lanzoni,Valéria Fuziy,Rogério Aoki Franco,Rita Maria Aparecida Monteiro Moura Maeda,Carlos Toshinori Lopes Filho,Gaspar de Jesus Linhares,Marcelo Moura |
author_role |
author |
author2 |
Lanzoni,Valéria Fuziy,Rogério Aoki Franco,Rita Maria Aparecida Monteiro Moura Maeda,Carlos Toshinori Lopes Filho,Gaspar de Jesus Linhares,Marcelo Moura |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Alves,Ana Karina Soares Lanzoni,Valéria Fuziy,Rogério Aoki Franco,Rita Maria Aparecida Monteiro Moura Maeda,Carlos Toshinori Lopes Filho,Gaspar de Jesus Linhares,Marcelo Moura |
dc.subject.por.fl_str_mv |
Mesenchymal Stem Cell Transplantation Liver Regeneration Hepatectomy Cell- and Tissue-Based Therapy Rats |
topic |
Mesenchymal Stem Cell Transplantation Liver Regeneration Hepatectomy Cell- and Tissue-Based Therapy Rats |
description |
Abstract Purpose: To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy. Methods: Forty rats were subjected to 70% hepatectomy and then ~106 mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted. Results: No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p<.05). Conclusions: Mesenchymal stem-cell therapy did not improve liver regeneration rate 3 d or 5 d after 70% hepatectomy in rats. Likewise, the therapy appeared not to affect liver function, proliferative index, or number of mitoses significantly. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000700515 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000700515 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020170070000002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.32 n.7 2017 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126444451921920 |