Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats

Detalhes bibliográficos
Autor(a) principal: Daglioglu,Yusuf Kenan
Data de Publicação: 2018
Outros Autores: Duzgun,Ozgul, Sarici,Inanc Samil, Ulutas,Kemal Turker
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400333
Resumo: Abstract Purpose: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. Methods: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days. Results: There was no statistically significant difference of the ABP and hydroxyproline levels between PRP and fibrin glue on the 7th day. There was no statistically significant difference between levels of proinflammatory cytokine (IL-6) (P=0.41), anti-inflammatory cytokine (IL-10) (P=0.35), and procalcitonin levels (P=0.63) on 1, 3 and 7 days. Conclusion: Fibrin glue and platelet rich plasma are shown to be effective in healing intestinal anastomoses without superior to each other.
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spelling Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in ratsAnastomosis, SurgicalFibrin Tissue AdhesivePlatelet-Rich PlasmaRats.Abstract Purpose: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. Methods: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days. Results: There was no statistically significant difference of the ABP and hydroxyproline levels between PRP and fibrin glue on the 7th day. There was no statistically significant difference between levels of proinflammatory cytokine (IL-6) (P=0.41), anti-inflammatory cytokine (IL-10) (P=0.35), and procalcitonin levels (P=0.63) on 1, 3 and 7 days. Conclusion: Fibrin glue and platelet rich plasma are shown to be effective in healing intestinal anastomoses without superior to each other.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2018-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400333Acta Cirúrgica Brasileira v.33 n.4 2018reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020180040000005info:eu-repo/semantics/openAccessDaglioglu,Yusuf KenanDuzgun,OzgulSarici,Inanc SamilUlutas,Kemal Turkereng2018-05-10T00:00:00Zoai:scielo:S0102-86502018000400333Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2018-05-10T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
title Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
spellingShingle Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
Daglioglu,Yusuf Kenan
Anastomosis, Surgical
Fibrin Tissue Adhesive
Platelet-Rich Plasma
Rats.
title_short Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
title_full Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
title_fullStr Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
title_full_unstemmed Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
title_sort Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats
author Daglioglu,Yusuf Kenan
author_facet Daglioglu,Yusuf Kenan
Duzgun,Ozgul
Sarici,Inanc Samil
Ulutas,Kemal Turker
author_role author
author2 Duzgun,Ozgul
Sarici,Inanc Samil
Ulutas,Kemal Turker
author2_role author
author
author
dc.contributor.author.fl_str_mv Daglioglu,Yusuf Kenan
Duzgun,Ozgul
Sarici,Inanc Samil
Ulutas,Kemal Turker
dc.subject.por.fl_str_mv Anastomosis, Surgical
Fibrin Tissue Adhesive
Platelet-Rich Plasma
Rats.
topic Anastomosis, Surgical
Fibrin Tissue Adhesive
Platelet-Rich Plasma
Rats.
description Abstract Purpose: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. Methods: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days. Results: There was no statistically significant difference of the ABP and hydroxyproline levels between PRP and fibrin glue on the 7th day. There was no statistically significant difference between levels of proinflammatory cytokine (IL-6) (P=0.41), anti-inflammatory cytokine (IL-10) (P=0.35), and procalcitonin levels (P=0.63) on 1, 3 and 7 days. Conclusion: Fibrin glue and platelet rich plasma are shown to be effective in healing intestinal anastomoses without superior to each other.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400333
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400333
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020180040000005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.33 n.4 2018
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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