Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies

Detalhes bibliográficos
Autor(a) principal: Mascena,Guilherme Veras
Data de Publicação: 2018
Outros Autores: Figueiredo Filho,Carlos Alberto, Lima Júnior,Marcos Antônio Xavier de, Oliveira,Thárcia Kiara Beserra, Gadelha,Diego Nery Benevides, Melo,Maria Cecília Santos Cavalcanti, Brandt,Carlos Teixeira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446
Resumo: Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
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spelling Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategiesPeritonitisCarbapenemsQuinolonesAgingRats.Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2018-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446Acta Cirúrgica Brasileira v.33 n.5 2018reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020180050000007info:eu-repo/semantics/openAccessMascena,Guilherme VerasFigueiredo Filho,Carlos AlbertoLima Júnior,Marcos Antônio Xavier deOliveira,Thárcia Kiara BeserraGadelha,Diego Nery BenevidesMelo,Maria Cecília Santos CavalcantiBrandt,Carlos Teixeiraeng2018-06-08T00:00:00Zoai:scielo:S0102-86502018000500446Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2018-06-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
title Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
spellingShingle Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
Mascena,Guilherme Veras
Peritonitis
Carbapenems
Quinolones
Aging
Rats.
title_short Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
title_full Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
title_fullStr Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
title_full_unstemmed Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
title_sort Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
author Mascena,Guilherme Veras
author_facet Mascena,Guilherme Veras
Figueiredo Filho,Carlos Alberto
Lima Júnior,Marcos Antônio Xavier de
Oliveira,Thárcia Kiara Beserra
Gadelha,Diego Nery Benevides
Melo,Maria Cecília Santos Cavalcanti
Brandt,Carlos Teixeira
author_role author
author2 Figueiredo Filho,Carlos Alberto
Lima Júnior,Marcos Antônio Xavier de
Oliveira,Thárcia Kiara Beserra
Gadelha,Diego Nery Benevides
Melo,Maria Cecília Santos Cavalcanti
Brandt,Carlos Teixeira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mascena,Guilherme Veras
Figueiredo Filho,Carlos Alberto
Lima Júnior,Marcos Antônio Xavier de
Oliveira,Thárcia Kiara Beserra
Gadelha,Diego Nery Benevides
Melo,Maria Cecília Santos Cavalcanti
Brandt,Carlos Teixeira
dc.subject.por.fl_str_mv Peritonitis
Carbapenems
Quinolones
Aging
Rats.
topic Peritonitis
Carbapenems
Quinolones
Aging
Rats.
description Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020180050000007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.33 n.5 2018
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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