Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446 |
Resumo: | Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis. |
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Acta Cirúrgica Brasileira (Online) |
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Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategiesPeritonitisCarbapenemsQuinolonesAgingRats.Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2018-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446Acta Cirúrgica Brasileira v.33 n.5 2018reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020180050000007info:eu-repo/semantics/openAccessMascena,Guilherme VerasFigueiredo Filho,Carlos AlbertoLima Júnior,Marcos Antônio Xavier deOliveira,Thárcia Kiara BeserraGadelha,Diego Nery BenevidesMelo,Maria Cecília Santos CavalcantiBrandt,Carlos Teixeiraeng2018-06-08T00:00:00Zoai:scielo:S0102-86502018000500446Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2018-06-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies |
title |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies |
spellingShingle |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies Mascena,Guilherme Veras Peritonitis Carbapenems Quinolones Aging Rats. |
title_short |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies |
title_full |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies |
title_fullStr |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies |
title_full_unstemmed |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies |
title_sort |
Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies |
author |
Mascena,Guilherme Veras |
author_facet |
Mascena,Guilherme Veras Figueiredo Filho,Carlos Alberto Lima Júnior,Marcos Antônio Xavier de Oliveira,Thárcia Kiara Beserra Gadelha,Diego Nery Benevides Melo,Maria Cecília Santos Cavalcanti Brandt,Carlos Teixeira |
author_role |
author |
author2 |
Figueiredo Filho,Carlos Alberto Lima Júnior,Marcos Antônio Xavier de Oliveira,Thárcia Kiara Beserra Gadelha,Diego Nery Benevides Melo,Maria Cecília Santos Cavalcanti Brandt,Carlos Teixeira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Mascena,Guilherme Veras Figueiredo Filho,Carlos Alberto Lima Júnior,Marcos Antônio Xavier de Oliveira,Thárcia Kiara Beserra Gadelha,Diego Nery Benevides Melo,Maria Cecília Santos Cavalcanti Brandt,Carlos Teixeira |
dc.subject.por.fl_str_mv |
Peritonitis Carbapenems Quinolones Aging Rats. |
topic |
Peritonitis Carbapenems Quinolones Aging Rats. |
description |
Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000500446 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020180050000007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.33 n.5 2018 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126444898615296 |