Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000300203 |
Resumo: | Abstract Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future. |
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Acta Cirúrgica Brasileira (Online) |
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Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in ratsAdenocarcinomaAcetatesUsneaRatsAbstract Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000300203Acta Cirúrgica Brasileira v.34 n.3 2019reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020190030000005info:eu-repo/semantics/openAccessMammadov,RenadSuleyman,BahadirAltuner,DurduDemirci,ElifCetin,NihalYilmaz,AdnanBaykal,HuseyinAlpcan,HilalTurumtay,Emine AkyuzSuleyman,Haliseng2019-04-29T00:00:00Zoai:scielo:S0102-86502019000300203Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2019-04-29T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats |
title |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats |
spellingShingle |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats Mammadov,Renad Adenocarcinoma Acetates Usnea Rats |
title_short |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats |
title_full |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats |
title_fullStr |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats |
title_full_unstemmed |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats |
title_sort |
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats |
author |
Mammadov,Renad |
author_facet |
Mammadov,Renad Suleyman,Bahadir Altuner,Durdu Demirci,Elif Cetin,Nihal Yilmaz,Adnan Baykal,Huseyin Alpcan,Hilal Turumtay,Emine Akyuz Suleyman,Halis |
author_role |
author |
author2 |
Suleyman,Bahadir Altuner,Durdu Demirci,Elif Cetin,Nihal Yilmaz,Adnan Baykal,Huseyin Alpcan,Hilal Turumtay,Emine Akyuz Suleyman,Halis |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mammadov,Renad Suleyman,Bahadir Altuner,Durdu Demirci,Elif Cetin,Nihal Yilmaz,Adnan Baykal,Huseyin Alpcan,Hilal Turumtay,Emine Akyuz Suleyman,Halis |
dc.subject.por.fl_str_mv |
Adenocarcinoma Acetates Usnea Rats |
topic |
Adenocarcinoma Acetates Usnea Rats |
description |
Abstract Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000300203 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000300203 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020190030000005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.34 n.3 2019 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126445335871488 |