Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines

Detalhes bibliográficos
Autor(a) principal: Udelsmann,Artur
Data de Publicação: 2009
Outros Autores: Silva,William Adalberto, Moraes,Ana Cristina de, Dreyer,Elisabeth
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400009
Resumo: PURPOSE: To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication. RESULTS: Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína. CONCLUSION: In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.
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spelling Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swinesPoisoningHemodynamicsAnesthetics, LocalSwinePURPOSE: To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication. RESULTS: Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína. CONCLUSION: In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400009Acta Cirúrgica Brasileira v.24 n.4 2009reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502009000400009info:eu-repo/semantics/openAccessUdelsmann,ArturSilva,William AdalbertoMoraes,Ana Cristina deDreyer,Elisabetheng2009-08-17T00:00:00Zoai:scielo:S0102-86502009000400009Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2009-08-17T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
title Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
spellingShingle Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
Udelsmann,Artur
Poisoning
Hemodynamics
Anesthetics, Local
Swine
title_short Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
title_full Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
title_fullStr Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
title_full_unstemmed Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
title_sort Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines
author Udelsmann,Artur
author_facet Udelsmann,Artur
Silva,William Adalberto
Moraes,Ana Cristina de
Dreyer,Elisabeth
author_role author
author2 Silva,William Adalberto
Moraes,Ana Cristina de
Dreyer,Elisabeth
author2_role author
author
author
dc.contributor.author.fl_str_mv Udelsmann,Artur
Silva,William Adalberto
Moraes,Ana Cristina de
Dreyer,Elisabeth
dc.subject.por.fl_str_mv Poisoning
Hemodynamics
Anesthetics, Local
Swine
topic Poisoning
Hemodynamics
Anesthetics, Local
Swine
description PURPOSE: To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication. RESULTS: Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína. CONCLUSION: In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502009000400009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.24 n.4 2009
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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