Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice

Detalhes bibliográficos
Autor(a) principal: Higa,Roberta Alves
Data de Publicação: 2011
Outros Autores: Aydos,Ricardo Dutra, Silva,Iandara Schettert, Ramalho,Rondon Tosta, Souza,Albert Schiaveto de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200009
Resumo: PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM. RESULTS: It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V. CONCLUSION: The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.
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spelling Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in miceCarcinogensColorectal NeoplasmsAzoxymethaneTabebuiaNaphthoquinonesMicePURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM. RESULTS: It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V. CONCLUSION: The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200009Acta Cirúrgica Brasileira v.26 n.2 2011reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502011000200009info:eu-repo/semantics/openAccessHiga,Roberta AlvesAydos,Ricardo DutraSilva,Iandara SchettertRamalho,Rondon TostaSouza,Albert Schiaveto deeng2011-03-21T00:00:00Zoai:scielo:S0102-86502011000200009Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2011-03-21T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
spellingShingle Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
Higa,Roberta Alves
Carcinogens
Colorectal Neoplasms
Azoxymethane
Tabebuia
Naphthoquinones
Mice
title_short Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_full Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_fullStr Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_full_unstemmed Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
title_sort Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice
author Higa,Roberta Alves
author_facet Higa,Roberta Alves
Aydos,Ricardo Dutra
Silva,Iandara Schettert
Ramalho,Rondon Tosta
Souza,Albert Schiaveto de
author_role author
author2 Aydos,Ricardo Dutra
Silva,Iandara Schettert
Ramalho,Rondon Tosta
Souza,Albert Schiaveto de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Higa,Roberta Alves
Aydos,Ricardo Dutra
Silva,Iandara Schettert
Ramalho,Rondon Tosta
Souza,Albert Schiaveto de
dc.subject.por.fl_str_mv Carcinogens
Colorectal Neoplasms
Azoxymethane
Tabebuia
Naphthoquinones
Mice
topic Carcinogens
Colorectal Neoplasms
Azoxymethane
Tabebuia
Naphthoquinones
Mice
description PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM. RESULTS: It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V. CONCLUSION: The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502011000200009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.26 n.2 2011
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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