Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500008 |
Resumo: | PURPOSE: To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS: The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1- Lactobacillus delbrueckii UFV-H2b20; 2- Bifidobacterium animalis var. lactis Bb12; 3- L. delbrueckii UFV-H2b20 plus B. animalis var. lactis Bb12; and 4- Saccharomyces boulardii) administered orally in drinking water throughout fourteen weeks. RESULTS: Consumption of lactobacilli and bifidobacteria alone resulted in a significant reduction of the total number of aberrant crypt foci (55.7% and 45.1%, respectively). Significant reduction in the number of these small foci (<3 aberrant crypts) was only observed in the group treated with lactobacilli (52.2%) in comparison to control group. The number of larger foci (>3 aberrant crypts) crypts had no significant reduction. CONCLUSION: L. delbrueckii UFV-H2b20 and B. animalis var. lactis Bb12 administered alone protect colonic preneoplastic lesions in mice, while the combined treatment of these bacteria and the administration of S.boulardii were not effective in reducing such colonic lesions. |
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Acta Cirúrgica Brasileira (Online) |
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Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colonColonPrecancerous Conditions1,2-DimethylhydrazineProbioticsMicePURPOSE: To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS: The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1- Lactobacillus delbrueckii UFV-H2b20; 2- Bifidobacterium animalis var. lactis Bb12; 3- L. delbrueckii UFV-H2b20 plus B. animalis var. lactis Bb12; and 4- Saccharomyces boulardii) administered orally in drinking water throughout fourteen weeks. RESULTS: Consumption of lactobacilli and bifidobacteria alone resulted in a significant reduction of the total number of aberrant crypt foci (55.7% and 45.1%, respectively). Significant reduction in the number of these small foci (<3 aberrant crypts) was only observed in the group treated with lactobacilli (52.2%) in comparison to control group. The number of larger foci (>3 aberrant crypts) crypts had no significant reduction. CONCLUSION: L. delbrueckii UFV-H2b20 and B. animalis var. lactis Bb12 administered alone protect colonic preneoplastic lesions in mice, while the combined treatment of these bacteria and the administration of S.boulardii were not effective in reducing such colonic lesions.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500008Acta Cirúrgica Brasileira v.28 n.5 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013000500008info:eu-repo/semantics/openAccessLiboredo,Juliana CostaAnastácio,Lucilene RezendePelúzio,Maria do Carmo GouveiaValente,Flávia XavierPenido,Luisa Costa PennaNicoli,Jacques RobertCorreia,Maria Isabel Toulson Davissoneng2013-05-21T00:00:00Zoai:scielo:S0102-86502013000500008Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-05-21T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon |
title |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon |
spellingShingle |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon Liboredo,Juliana Costa Colon Precancerous Conditions 1,2-Dimethylhydrazine Probiotics Mice |
title_short |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon |
title_full |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon |
title_fullStr |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon |
title_full_unstemmed |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon |
title_sort |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon |
author |
Liboredo,Juliana Costa |
author_facet |
Liboredo,Juliana Costa Anastácio,Lucilene Rezende Pelúzio,Maria do Carmo Gouveia Valente,Flávia Xavier Penido,Luisa Costa Penna Nicoli,Jacques Robert Correia,Maria Isabel Toulson Davisson |
author_role |
author |
author2 |
Anastácio,Lucilene Rezende Pelúzio,Maria do Carmo Gouveia Valente,Flávia Xavier Penido,Luisa Costa Penna Nicoli,Jacques Robert Correia,Maria Isabel Toulson Davisson |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Liboredo,Juliana Costa Anastácio,Lucilene Rezende Pelúzio,Maria do Carmo Gouveia Valente,Flávia Xavier Penido,Luisa Costa Penna Nicoli,Jacques Robert Correia,Maria Isabel Toulson Davisson |
dc.subject.por.fl_str_mv |
Colon Precancerous Conditions 1,2-Dimethylhydrazine Probiotics Mice |
topic |
Colon Precancerous Conditions 1,2-Dimethylhydrazine Probiotics Mice |
description |
PURPOSE: To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS: The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1- Lactobacillus delbrueckii UFV-H2b20; 2- Bifidobacterium animalis var. lactis Bb12; 3- L. delbrueckii UFV-H2b20 plus B. animalis var. lactis Bb12; and 4- Saccharomyces boulardii) administered orally in drinking water throughout fourteen weeks. RESULTS: Consumption of lactobacilli and bifidobacteria alone resulted in a significant reduction of the total number of aberrant crypt foci (55.7% and 45.1%, respectively). Significant reduction in the number of these small foci (<3 aberrant crypts) was only observed in the group treated with lactobacilli (52.2%) in comparison to control group. The number of larger foci (>3 aberrant crypts) crypts had no significant reduction. CONCLUSION: L. delbrueckii UFV-H2b20 and B. animalis var. lactis Bb12 administered alone protect colonic preneoplastic lesions in mice, while the combined treatment of these bacteria and the administration of S.boulardii were not effective in reducing such colonic lesions. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502013000500008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.28 n.5 2013 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
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1752126441763373056 |