Evaluation of lipoic acid topical application on rats skin wound healing
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001000004 |
Resumo: | PURPOSE: To evaluate the effects of lipoic acid (thioctic acid) topical application on wound healing on rats skin, and the consequences of lipoic acid nanoencapsulation on this process. METHODS: The model used was the healing activity on wounds induced by surgical incision on rats skin (n = 44). The parameters analyzed (11 days) were wound healing rate and histology (vascular proliferation, polymorphonuclear or mononuclear cells, and collagen synthesis or reepithelialization), after application of free lipoic acid or lipoic acid- loaded nanocapsules. The antioxidant activity of these formulations was evaluated by lipid peroxidation test. RESULTS: It was demonstrated for the first time that the topical application of lipoic acid improves wound healing. On the seventh day after surgery, the animals treated with lipoic acid showed increased healing rate (60.7 ± 8.4%) compared to the negative control group (43.0 ± 17.4%), as so improvement of histological parameters. The nanoencapsulation reverted the pro-oxidant activity presented in vitro by lipoic acid, whereas diminished wound repair. CONCLUSIONS: The topical application of lipoic acid produced an increase in the skin wound healing, which may be related to its pro-oxidant activity. On the other hand, the nanoencapsulation of the lipoic acid reversed the pro-oxidant activity, although presented minor healing activity. |
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Acta Cirúrgica Brasileira (Online) |
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Evaluation of lipoic acid topical application on rats skin wound healingThioctic AcidWound HealingNanocapsulesPURPOSE: To evaluate the effects of lipoic acid (thioctic acid) topical application on wound healing on rats skin, and the consequences of lipoic acid nanoencapsulation on this process. METHODS: The model used was the healing activity on wounds induced by surgical incision on rats skin (n = 44). The parameters analyzed (11 days) were wound healing rate and histology (vascular proliferation, polymorphonuclear or mononuclear cells, and collagen synthesis or reepithelialization), after application of free lipoic acid or lipoic acid- loaded nanocapsules. The antioxidant activity of these formulations was evaluated by lipid peroxidation test. RESULTS: It was demonstrated for the first time that the topical application of lipoic acid improves wound healing. On the seventh day after surgery, the animals treated with lipoic acid showed increased healing rate (60.7 ± 8.4%) compared to the negative control group (43.0 ± 17.4%), as so improvement of histological parameters. The nanoencapsulation reverted the pro-oxidant activity presented in vitro by lipoic acid, whereas diminished wound repair. CONCLUSIONS: The topical application of lipoic acid produced an increase in the skin wound healing, which may be related to its pro-oxidant activity. On the other hand, the nanoencapsulation of the lipoic acid reversed the pro-oxidant activity, although presented minor healing activity.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001000004Acta Cirúrgica Brasileira v.28 n.10 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013001000004info:eu-repo/semantics/openAccessKülkamp-Guerreiro,Irene ClemesSouza,Marielly NunesBianchin,Mariana DominguesIsoppo,MateusFreitas,Joana SachettiAlves,João AlexPiovezan,Anna PaulaPohlmann,Adriana RaffinGuterres,Sílvia Stanisçuaskieng2013-10-07T00:00:00Zoai:scielo:S0102-86502013001000004Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-10-07T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Evaluation of lipoic acid topical application on rats skin wound healing |
title |
Evaluation of lipoic acid topical application on rats skin wound healing |
spellingShingle |
Evaluation of lipoic acid topical application on rats skin wound healing Külkamp-Guerreiro,Irene Clemes Thioctic Acid Wound Healing Nanocapsules |
title_short |
Evaluation of lipoic acid topical application on rats skin wound healing |
title_full |
Evaluation of lipoic acid topical application on rats skin wound healing |
title_fullStr |
Evaluation of lipoic acid topical application on rats skin wound healing |
title_full_unstemmed |
Evaluation of lipoic acid topical application on rats skin wound healing |
title_sort |
Evaluation of lipoic acid topical application on rats skin wound healing |
author |
Külkamp-Guerreiro,Irene Clemes |
author_facet |
Külkamp-Guerreiro,Irene Clemes Souza,Marielly Nunes Bianchin,Mariana Domingues Isoppo,Mateus Freitas,Joana Sachetti Alves,João Alex Piovezan,Anna Paula Pohlmann,Adriana Raffin Guterres,Sílvia Stanisçuaski |
author_role |
author |
author2 |
Souza,Marielly Nunes Bianchin,Mariana Domingues Isoppo,Mateus Freitas,Joana Sachetti Alves,João Alex Piovezan,Anna Paula Pohlmann,Adriana Raffin Guterres,Sílvia Stanisçuaski |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Külkamp-Guerreiro,Irene Clemes Souza,Marielly Nunes Bianchin,Mariana Domingues Isoppo,Mateus Freitas,Joana Sachetti Alves,João Alex Piovezan,Anna Paula Pohlmann,Adriana Raffin Guterres,Sílvia Stanisçuaski |
dc.subject.por.fl_str_mv |
Thioctic Acid Wound Healing Nanocapsules |
topic |
Thioctic Acid Wound Healing Nanocapsules |
description |
PURPOSE: To evaluate the effects of lipoic acid (thioctic acid) topical application on wound healing on rats skin, and the consequences of lipoic acid nanoencapsulation on this process. METHODS: The model used was the healing activity on wounds induced by surgical incision on rats skin (n = 44). The parameters analyzed (11 days) were wound healing rate and histology (vascular proliferation, polymorphonuclear or mononuclear cells, and collagen synthesis or reepithelialization), after application of free lipoic acid or lipoic acid- loaded nanocapsules. The antioxidant activity of these formulations was evaluated by lipid peroxidation test. RESULTS: It was demonstrated for the first time that the topical application of lipoic acid improves wound healing. On the seventh day after surgery, the animals treated with lipoic acid showed increased healing rate (60.7 ± 8.4%) compared to the negative control group (43.0 ± 17.4%), as so improvement of histological parameters. The nanoencapsulation reverted the pro-oxidant activity presented in vitro by lipoic acid, whereas diminished wound repair. CONCLUSIONS: The topical application of lipoic acid produced an increase in the skin wound healing, which may be related to its pro-oxidant activity. On the other hand, the nanoencapsulation of the lipoic acid reversed the pro-oxidant activity, although presented minor healing activity. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001000004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001000004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502013001000004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.28 n.10 2013 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442117791744 |