Angiogenic activity of Calendula officinalis flowers L. in rats

• Autor(a) principal: Parente,Leila Maria Leal
• Data de Publicação: 2011
• Outros Autores: Andrade,Maria Auxiliadora, Brito,Luiz Augusto Batista, Moura,Veridiana Maria Brianezi Dignani de, Miguel,Marina Pacheco, Lino-Júnior,Ruy de Souza, Tresvenzol,Leonice Faustino Manrique, Paula,José Realino de, Paulo,Neusa Margarida
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005
• topic: Calendula; Wound Healing; Neovascularization, Physiologic; Plants, Medicinal; Rats

Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.