Angiogenic activity of Calendula officinalis flowers L. in rats

Detalhes bibliográficos
Autor(a) principal: Parente,Leila Maria Leal
Data de Publicação: 2011
Outros Autores: Andrade,Maria Auxiliadora, Brito,Luiz Augusto Batista, Moura,Veridiana Maria Brianezi Dignani de, Miguel,Marina Pacheco, Lino-Júnior,Ruy de Souza, Tresvenzol,Leonice Faustino Manrique, Paula,José Realino de, Paulo,Neusa Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005
Resumo: Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.
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spelling Angiogenic activity of Calendula officinalis flowers L. in ratsCalendulaWound HealingNeovascularization, PhysiologicPlants, MedicinalRatsPurpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005Acta Cirúrgica Brasileira v.26 n.1 2011reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502011000100005info:eu-repo/semantics/openAccessParente,Leila Maria LealAndrade,Maria AuxiliadoraBrito,Luiz Augusto BatistaMoura,Veridiana Maria Brianezi Dignani deMiguel,Marina PachecoLino-Júnior,Ruy de SouzaTresvenzol,Leonice Faustino ManriquePaula,José Realino dePaulo,Neusa Margaridaeng2011-04-08T00:00:00Zoai:scielo:S0102-86502011000100005Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2011-04-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Angiogenic activity of Calendula officinalis flowers L. in rats
title Angiogenic activity of Calendula officinalis flowers L. in rats
spellingShingle Angiogenic activity of Calendula officinalis flowers L. in rats
Parente,Leila Maria Leal
Calendula
Wound Healing
Neovascularization, Physiologic
Plants, Medicinal
Rats
title_short Angiogenic activity of Calendula officinalis flowers L. in rats
title_full Angiogenic activity of Calendula officinalis flowers L. in rats
title_fullStr Angiogenic activity of Calendula officinalis flowers L. in rats
title_full_unstemmed Angiogenic activity of Calendula officinalis flowers L. in rats
title_sort Angiogenic activity of Calendula officinalis flowers L. in rats
author Parente,Leila Maria Leal
author_facet Parente,Leila Maria Leal
Andrade,Maria Auxiliadora
Brito,Luiz Augusto Batista
Moura,Veridiana Maria Brianezi Dignani de
Miguel,Marina Pacheco
Lino-Júnior,Ruy de Souza
Tresvenzol,Leonice Faustino Manrique
Paula,José Realino de
Paulo,Neusa Margarida
author_role author
author2 Andrade,Maria Auxiliadora
Brito,Luiz Augusto Batista
Moura,Veridiana Maria Brianezi Dignani de
Miguel,Marina Pacheco
Lino-Júnior,Ruy de Souza
Tresvenzol,Leonice Faustino Manrique
Paula,José Realino de
Paulo,Neusa Margarida
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Parente,Leila Maria Leal
Andrade,Maria Auxiliadora
Brito,Luiz Augusto Batista
Moura,Veridiana Maria Brianezi Dignani de
Miguel,Marina Pacheco
Lino-Júnior,Ruy de Souza
Tresvenzol,Leonice Faustino Manrique
Paula,José Realino de
Paulo,Neusa Margarida
dc.subject.por.fl_str_mv Calendula
Wound Healing
Neovascularization, Physiologic
Plants, Medicinal
Rats
topic Calendula
Wound Healing
Neovascularization, Physiologic
Plants, Medicinal
Rats
description Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502011000100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.26 n.1 2011
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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