Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats

Detalhes bibliográficos
Autor(a) principal: Aires Neto,Tertuliano
Data de Publicação: 2005
Outros Autores: Cavalcante,Jeancarlo Fernandes, Brandão-Neto,José, Araújo Filho,Irami, Almeida,Maria das Graças, Rezende,Adriana Augusto de, Egito,Eryvaldo Sócrates Tabosa, Azevedo,Ítalo Medeiros de, Pinheiro,Laísa Araújo Mohana, Medeiros,Vítor Brasil, Medeiros,Aldo da Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000700019
Resumo: PURPOSE: A comparison was done between the F. Paulino jejunal pouch (FP) and a jejunal pouch (JP) as esophagus-duodenum interpositional graft, for replacing the stomach after total gastrectomy. It was investigated the effect of the two procedures on esophagus histology, nutritional state and serum gastrin in rats. METHODS: Male Wistar rats weighing 282±17g were randomly submitted to sham operation (S), FP and JP after total gastrectomy. After eight weeks the rats were killed with overdose of anesthetic and tissue was taken from the distal esophagus for histology. Serum levels of total proteins, albumin, iron, transferring, folate, cobalamine, calcium, as well as serum gastrin were determined. Survival was considered. RESULTS: Fourty six rats were operated and thirty survived for eight weeks. Five (33.3%) died after FP and 11 (52.3%) after JP (p<0.05). Postoperative esophagitis occurred in 6 JP rats. At 8th week, no difference was observed on body weight when compared FP and JP rats (p>0.05). The JP rats had a significant decrease in serum albumin, glucose, transferrin, iron, folate and calcium, compared to sham (p<0.05). Serum gastrin, iron and calcium were significantly higher in JP rats than in FP rats (p<0.05). In FP rats, transferrin and cobalamine showed significant decrease comparing the preoperative with 8th week levels (p<0.05). CONCLUSION: F. Paulino pouch in rats had lower mortality than JP, and esophagitis was not detected in it. JP rats had serum gastrin, iron and calcium unaffected, possibly because of preservation of duodenal passage.
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spelling Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in ratsTotal gastrectomyJejunal pouchNutritionGastrinRefluxPURPOSE: A comparison was done between the F. Paulino jejunal pouch (FP) and a jejunal pouch (JP) as esophagus-duodenum interpositional graft, for replacing the stomach after total gastrectomy. It was investigated the effect of the two procedures on esophagus histology, nutritional state and serum gastrin in rats. METHODS: Male Wistar rats weighing 282±17g were randomly submitted to sham operation (S), FP and JP after total gastrectomy. After eight weeks the rats were killed with overdose of anesthetic and tissue was taken from the distal esophagus for histology. Serum levels of total proteins, albumin, iron, transferring, folate, cobalamine, calcium, as well as serum gastrin were determined. Survival was considered. RESULTS: Fourty six rats were operated and thirty survived for eight weeks. Five (33.3%) died after FP and 11 (52.3%) after JP (p<0.05). Postoperative esophagitis occurred in 6 JP rats. At 8th week, no difference was observed on body weight when compared FP and JP rats (p>0.05). The JP rats had a significant decrease in serum albumin, glucose, transferrin, iron, folate and calcium, compared to sham (p<0.05). Serum gastrin, iron and calcium were significantly higher in JP rats than in FP rats (p<0.05). In FP rats, transferrin and cobalamine showed significant decrease comparing the preoperative with 8th week levels (p<0.05). CONCLUSION: F. Paulino pouch in rats had lower mortality than JP, and esophagitis was not detected in it. JP rats had serum gastrin, iron and calcium unaffected, possibly because of preservation of duodenal passage.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2005-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000700019Acta Cirúrgica Brasileira v.20 suppl.1 2005reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502005000700019info:eu-repo/semantics/openAccessAires Neto,TertulianoCavalcante,Jeancarlo FernandesBrandão-Neto,JoséAraújo Filho,IramiAlmeida,Maria das GraçasRezende,Adriana Augusto deEgito,Eryvaldo Sócrates TabosaAzevedo,Ítalo Medeiros dePinheiro,Laísa Araújo MohanaMedeiros,Vítor BrasilMedeiros,Aldo da Cunhaeng2007-05-28T00:00:00Zoai:scielo:S0102-86502005000700019Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-05-28T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
title Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
spellingShingle Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
Aires Neto,Tertuliano
Total gastrectomy
Jejunal pouch
Nutrition
Gastrin
Reflux
title_short Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
title_full Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
title_fullStr Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
title_full_unstemmed Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
title_sort Total gastrectomy with substitution of stomach by jejunal pouch with and without duodenal passage: study in rats
author Aires Neto,Tertuliano
author_facet Aires Neto,Tertuliano
Cavalcante,Jeancarlo Fernandes
Brandão-Neto,José
Araújo Filho,Irami
Almeida,Maria das Graças
Rezende,Adriana Augusto de
Egito,Eryvaldo Sócrates Tabosa
Azevedo,Ítalo Medeiros de
Pinheiro,Laísa Araújo Mohana
Medeiros,Vítor Brasil
Medeiros,Aldo da Cunha
author_role author
author2 Cavalcante,Jeancarlo Fernandes
Brandão-Neto,José
Araújo Filho,Irami
Almeida,Maria das Graças
Rezende,Adriana Augusto de
Egito,Eryvaldo Sócrates Tabosa
Azevedo,Ítalo Medeiros de
Pinheiro,Laísa Araújo Mohana
Medeiros,Vítor Brasil
Medeiros,Aldo da Cunha
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Aires Neto,Tertuliano
Cavalcante,Jeancarlo Fernandes
Brandão-Neto,José
Araújo Filho,Irami
Almeida,Maria das Graças
Rezende,Adriana Augusto de
Egito,Eryvaldo Sócrates Tabosa
Azevedo,Ítalo Medeiros de
Pinheiro,Laísa Araújo Mohana
Medeiros,Vítor Brasil
Medeiros,Aldo da Cunha
dc.subject.por.fl_str_mv Total gastrectomy
Jejunal pouch
Nutrition
Gastrin
Reflux
topic Total gastrectomy
Jejunal pouch
Nutrition
Gastrin
Reflux
description PURPOSE: A comparison was done between the F. Paulino jejunal pouch (FP) and a jejunal pouch (JP) as esophagus-duodenum interpositional graft, for replacing the stomach after total gastrectomy. It was investigated the effect of the two procedures on esophagus histology, nutritional state and serum gastrin in rats. METHODS: Male Wistar rats weighing 282±17g were randomly submitted to sham operation (S), FP and JP after total gastrectomy. After eight weeks the rats were killed with overdose of anesthetic and tissue was taken from the distal esophagus for histology. Serum levels of total proteins, albumin, iron, transferring, folate, cobalamine, calcium, as well as serum gastrin were determined. Survival was considered. RESULTS: Fourty six rats were operated and thirty survived for eight weeks. Five (33.3%) died after FP and 11 (52.3%) after JP (p<0.05). Postoperative esophagitis occurred in 6 JP rats. At 8th week, no difference was observed on body weight when compared FP and JP rats (p>0.05). The JP rats had a significant decrease in serum albumin, glucose, transferrin, iron, folate and calcium, compared to sham (p<0.05). Serum gastrin, iron and calcium were significantly higher in JP rats than in FP rats (p<0.05). In FP rats, transferrin and cobalamine showed significant decrease comparing the preoperative with 8th week levels (p<0.05). CONCLUSION: F. Paulino pouch in rats had lower mortality than JP, and esophagitis was not detected in it. JP rats had serum gastrin, iron and calcium unaffected, possibly because of preservation of duodenal passage.
publishDate 2005
dc.date.none.fl_str_mv 2005-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000700019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000700019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502005000700019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.20 suppl.1 2005
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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