Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000700007 |
Resumo: | PURPOSE: To verify if rat kidneys lesioned by ischaemia followed by reperfusion are affected by cyclosporine A (CsA). METHODS: Male Wistar rats were randomly divided into three groups, control (GS) and experimental (G1 and G2). G1 was subdivided in two: G1A composed of animals submitted to 60 minutes ischaemia and G1C with the same ischaemic procedure associated to 20 mg/kg/day CsA. Group G2 was subdivided and treated in the same way as G1 except that ischaemia was applied only for 40 minutes. Clamping the left renal artery followed by right side nephrectomy induced kidney ischaemia. Serum urea and creatinine were quantified on the day of surgery (D0) and in the following day (D1). Twenty four hours after reperfusion the left kidney was removed and histologically analyzed. RESULTS: Group GS had normal values for urea and creatinine both on D0 and D1 and did not show structural alterations. Renal function was not significantly different when G2C was compared to GS (p>0.05). Tissue lesions were smaller in G2C than in the other groups. CONCLUSIONS: Renal function was protected by CsA, which also reduced tissue lesions in the kidneys of rats submitted to 40 minutes ischaemia. |
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Acta Cirúrgica Brasileira (Online) |
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Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusionCyclosporineKidneyIschaemia/ReperfusionPURPOSE: To verify if rat kidneys lesioned by ischaemia followed by reperfusion are affected by cyclosporine A (CsA). METHODS: Male Wistar rats were randomly divided into three groups, control (GS) and experimental (G1 and G2). G1 was subdivided in two: G1A composed of animals submitted to 60 minutes ischaemia and G1C with the same ischaemic procedure associated to 20 mg/kg/day CsA. Group G2 was subdivided and treated in the same way as G1 except that ischaemia was applied only for 40 minutes. Clamping the left renal artery followed by right side nephrectomy induced kidney ischaemia. Serum urea and creatinine were quantified on the day of surgery (D0) and in the following day (D1). Twenty four hours after reperfusion the left kidney was removed and histologically analyzed. RESULTS: Group GS had normal values for urea and creatinine both on D0 and D1 and did not show structural alterations. Renal function was not significantly different when G2C was compared to GS (p>0.05). Tissue lesions were smaller in G2C than in the other groups. CONCLUSIONS: Renal function was protected by CsA, which also reduced tissue lesions in the kidneys of rats submitted to 40 minutes ischaemia.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000700007Acta Cirúrgica Brasileira v.23 suppl.1 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000700007info:eu-repo/semantics/openAccessCologna,Adauto JoséLima,Lucy Vieira da SilvaTucci Jr.,SilvioSuaid,Haylton JorgeReis,Rodolfo BorgesTirapelli,Luis FernandoRodrigues Jr.,Antônio AntunesMartins,Antonio Carlos Pereiraeng2008-05-20T00:00:00Zoai:scielo:S0102-86502008000700007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-05-20T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion |
title |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion |
spellingShingle |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion Cologna,Adauto José Cyclosporine Kidney Ischaemia/Reperfusion |
title_short |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion |
title_full |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion |
title_fullStr |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion |
title_full_unstemmed |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion |
title_sort |
Cyclosporine action on kidneys of rats submitted to normothermic ischaemia and reperfusion |
author |
Cologna,Adauto José |
author_facet |
Cologna,Adauto José Lima,Lucy Vieira da Silva Tucci Jr.,Silvio Suaid,Haylton Jorge Reis,Rodolfo Borges Tirapelli,Luis Fernando Rodrigues Jr.,Antônio Antunes Martins,Antonio Carlos Pereira |
author_role |
author |
author2 |
Lima,Lucy Vieira da Silva Tucci Jr.,Silvio Suaid,Haylton Jorge Reis,Rodolfo Borges Tirapelli,Luis Fernando Rodrigues Jr.,Antônio Antunes Martins,Antonio Carlos Pereira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Cologna,Adauto José Lima,Lucy Vieira da Silva Tucci Jr.,Silvio Suaid,Haylton Jorge Reis,Rodolfo Borges Tirapelli,Luis Fernando Rodrigues Jr.,Antônio Antunes Martins,Antonio Carlos Pereira |
dc.subject.por.fl_str_mv |
Cyclosporine Kidney Ischaemia/Reperfusion |
topic |
Cyclosporine Kidney Ischaemia/Reperfusion |
description |
PURPOSE: To verify if rat kidneys lesioned by ischaemia followed by reperfusion are affected by cyclosporine A (CsA). METHODS: Male Wistar rats were randomly divided into three groups, control (GS) and experimental (G1 and G2). G1 was subdivided in two: G1A composed of animals submitted to 60 minutes ischaemia and G1C with the same ischaemic procedure associated to 20 mg/kg/day CsA. Group G2 was subdivided and treated in the same way as G1 except that ischaemia was applied only for 40 minutes. Clamping the left renal artery followed by right side nephrectomy induced kidney ischaemia. Serum urea and creatinine were quantified on the day of surgery (D0) and in the following day (D1). Twenty four hours after reperfusion the left kidney was removed and histologically analyzed. RESULTS: Group GS had normal values for urea and creatinine both on D0 and D1 and did not show structural alterations. Renal function was not significantly different when G2C was compared to GS (p>0.05). Tissue lesions were smaller in G2C than in the other groups. CONCLUSIONS: Renal function was protected by CsA, which also reduced tissue lesions in the kidneys of rats submitted to 40 minutes ischaemia. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000700007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000700007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502008000700007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.23 suppl.1 2008 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126439460700160 |