The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury

Detalhes bibliográficos
Autor(a) principal: Pimenta,Márcio Benedito Palma
Data de Publicação: 2007
Outros Autores: Aguilar-Nascimento,José Eduardo de, Martins,Dely Cristina, Silva,Daniele Ribastski da, Bacelo,Kátia Leston, Bocchese,Isabel Cristina, Zaffani,Sarai, Zaffani,Elieser, Silveira,Érika Alessandra Oliveira, Carmo,Aracelle Victor do, Ferreira,Simone Sampaio Saldanha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700008
Resumo: PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6±197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08±108.52 [4-372] pg/mL) and posterior cava veins (127.58±109.15 [8-388] pg/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.
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spelling The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injuryIschemiaIL-6C-reactive proteinMucosaInflammationPURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6±197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08±108.52 [4-372] pg/mL) and posterior cava veins (127.58±109.15 [8-388] pg/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700008Acta Cirúrgica Brasileira v.22 suppl.1 2007reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502007000700008info:eu-repo/semantics/openAccessPimenta,Márcio Benedito PalmaAguilar-Nascimento,José Eduardo deMartins,Dely CristinaSilva,Daniele Ribastski daBacelo,Kátia LestonBocchese,Isabel CristinaZaffani,SaraiZaffani,ElieserSilveira,Érika Alessandra OliveiraCarmo,Aracelle Victor doFerreira,Simone Sampaio Saldanhaeng2007-04-26T00:00:00Zoai:scielo:S0102-86502007000700008Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-04-26T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
title The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
spellingShingle The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
Pimenta,Márcio Benedito Palma
Ischemia
IL-6
C-reactive protein
Mucosa
Inflammation
title_short The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
title_full The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
title_fullStr The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
title_full_unstemmed The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
title_sort The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury
author Pimenta,Márcio Benedito Palma
author_facet Pimenta,Márcio Benedito Palma
Aguilar-Nascimento,José Eduardo de
Martins,Dely Cristina
Silva,Daniele Ribastski da
Bacelo,Kátia Leston
Bocchese,Isabel Cristina
Zaffani,Sarai
Zaffani,Elieser
Silveira,Érika Alessandra Oliveira
Carmo,Aracelle Victor do
Ferreira,Simone Sampaio Saldanha
author_role author
author2 Aguilar-Nascimento,José Eduardo de
Martins,Dely Cristina
Silva,Daniele Ribastski da
Bacelo,Kátia Leston
Bocchese,Isabel Cristina
Zaffani,Sarai
Zaffani,Elieser
Silveira,Érika Alessandra Oliveira
Carmo,Aracelle Victor do
Ferreira,Simone Sampaio Saldanha
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pimenta,Márcio Benedito Palma
Aguilar-Nascimento,José Eduardo de
Martins,Dely Cristina
Silva,Daniele Ribastski da
Bacelo,Kátia Leston
Bocchese,Isabel Cristina
Zaffani,Sarai
Zaffani,Elieser
Silveira,Érika Alessandra Oliveira
Carmo,Aracelle Victor do
Ferreira,Simone Sampaio Saldanha
dc.subject.por.fl_str_mv Ischemia
IL-6
C-reactive protein
Mucosa
Inflammation
topic Ischemia
IL-6
C-reactive protein
Mucosa
Inflammation
description PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6±197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08±108.52 [4-372] pg/mL) and posterior cava veins (127.58±109.15 [8-388] pg/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502007000700008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.22 suppl.1 2007
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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