Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model

Detalhes bibliográficos
Autor(a) principal: Bülbüller,Nurullah
Data de Publicação: 2018
Outros Autores: Karakaş,Barış Rafet, Yıldırım,Hülya Tosun, Yaprak,Muhittin, Vural,Veli, Akbaş,Sadıka Halide, Karaveli,Arzu, Sezer,Cem
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000200163
Resumo: Abstract Purpose: To evaluate the effect of a new cross-linked hyaluronan (NCHA) gel on healing of the staple line in an experimental sleeve gastrectomy. Methods: Eighteen rats were randomly divided into three groups. The control group (n = 6) received no medication. In the saline group (n = 6) and NCHA gel group (n = 6), saline and NCHA gel were respectively administered onto the staple line and intraperitoneally into the abdominal cavity after the standard stapling procedure. Results: The fibroblast activity and collagen deposition were significantly higher in the NCHA gel group than in the control group (p = 0.00, p = 0.017) and saline group (p = 0.004, p = 0.015). The tissue hydroxyproline protein level was significantly higher in the NCHA gel group than in the control group (p = 0.041). Adhesion formation was significantly lower in the NCHA gel group than in the control and saline groups (p = 0.015, p = 0.041). Conclusions: New cross-linked hyaluronan gel could be an effective approach to improve staple line wound healing and prevent potential leakage after sleeve gastrectomy. Moreover, NCHA gel helps to prevent adhesion formation without compromising healing of the staple line.
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spelling Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat modelTissue AdhesionsWound HealingBariatric SurgeryGastrectomyHyaluronan GelRats.Abstract Purpose: To evaluate the effect of a new cross-linked hyaluronan (NCHA) gel on healing of the staple line in an experimental sleeve gastrectomy. Methods: Eighteen rats were randomly divided into three groups. The control group (n = 6) received no medication. In the saline group (n = 6) and NCHA gel group (n = 6), saline and NCHA gel were respectively administered onto the staple line and intraperitoneally into the abdominal cavity after the standard stapling procedure. Results: The fibroblast activity and collagen deposition were significantly higher in the NCHA gel group than in the control group (p = 0.00, p = 0.017) and saline group (p = 0.004, p = 0.015). The tissue hydroxyproline protein level was significantly higher in the NCHA gel group than in the control group (p = 0.041). Adhesion formation was significantly lower in the NCHA gel group than in the control and saline groups (p = 0.015, p = 0.041). Conclusions: New cross-linked hyaluronan gel could be an effective approach to improve staple line wound healing and prevent potential leakage after sleeve gastrectomy. Moreover, NCHA gel helps to prevent adhesion formation without compromising healing of the staple line.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2018-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000200163Acta Cirúrgica Brasileira v.33 n.2 2018reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020180020000008info:eu-repo/semantics/openAccessBülbüller,NurullahKarakaş,Barış RafetYıldırım,Hülya TosunYaprak,MuhittinVural,VeliAkbaş,Sadıka HalideKaraveli,ArzuSezer,Cemeng2018-03-01T00:00:00Zoai:scielo:S0102-86502018000200163Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2018-03-01T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
title Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
spellingShingle Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
Bülbüller,Nurullah
Tissue Adhesions
Wound Healing
Bariatric Surgery
Gastrectomy
Hyaluronan Gel
Rats.
title_short Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
title_full Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
title_fullStr Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
title_full_unstemmed Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
title_sort Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
author Bülbüller,Nurullah
author_facet Bülbüller,Nurullah
Karakaş,Barış Rafet
Yıldırım,Hülya Tosun
Yaprak,Muhittin
Vural,Veli
Akbaş,Sadıka Halide
Karaveli,Arzu
Sezer,Cem
author_role author
author2 Karakaş,Barış Rafet
Yıldırım,Hülya Tosun
Yaprak,Muhittin
Vural,Veli
Akbaş,Sadıka Halide
Karaveli,Arzu
Sezer,Cem
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bülbüller,Nurullah
Karakaş,Barış Rafet
Yıldırım,Hülya Tosun
Yaprak,Muhittin
Vural,Veli
Akbaş,Sadıka Halide
Karaveli,Arzu
Sezer,Cem
dc.subject.por.fl_str_mv Tissue Adhesions
Wound Healing
Bariatric Surgery
Gastrectomy
Hyaluronan Gel
Rats.
topic Tissue Adhesions
Wound Healing
Bariatric Surgery
Gastrectomy
Hyaluronan Gel
Rats.
description Abstract Purpose: To evaluate the effect of a new cross-linked hyaluronan (NCHA) gel on healing of the staple line in an experimental sleeve gastrectomy. Methods: Eighteen rats were randomly divided into three groups. The control group (n = 6) received no medication. In the saline group (n = 6) and NCHA gel group (n = 6), saline and NCHA gel were respectively administered onto the staple line and intraperitoneally into the abdominal cavity after the standard stapling procedure. Results: The fibroblast activity and collagen deposition were significantly higher in the NCHA gel group than in the control group (p = 0.00, p = 0.017) and saline group (p = 0.004, p = 0.015). The tissue hydroxyproline protein level was significantly higher in the NCHA gel group than in the control group (p = 0.041). Adhesion formation was significantly lower in the NCHA gel group than in the control and saline groups (p = 0.015, p = 0.041). Conclusions: New cross-linked hyaluronan gel could be an effective approach to improve staple line wound healing and prevent potential leakage after sleeve gastrectomy. Moreover, NCHA gel helps to prevent adhesion formation without compromising healing of the staple line.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000200163
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000200163
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020180020000008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.33 n.2 2018
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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