Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000700009 |
Resumo: | PURPOSE: The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration. METHODS: Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67% partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody. RESULTS: Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively). CONCLUSION: The aqueous extract of Sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats. |
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Acta Cirúrgica Brasileira (Online) |
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Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomyPartial HepatectomyLiver RegenerationSida cordifoliaMedicinal PlantPURPOSE: The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration. METHODS: Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67% partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody. RESULTS: Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively). CONCLUSION: The aqueous extract of Sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2006-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000700009Acta Cirúrgica Brasileira v.21 suppl.1 2006reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502006000700009info:eu-repo/semantics/openAccessSilva,Renata LemosMelo,Gustavo Barreto deMelo,Valdinaldo Aragão deAntoniolli,Ângelo RobertoMichellone,Paulo Roberto TeixeiraZucoloto,SérgioPicinato,Maria Aparecida Neves CardosoFranco,Clarice Fleury FinaMota,Gustavo de AssisCastro e Silva,Orlando deeng2006-09-20T00:00:00Zoai:scielo:S0102-86502006000700009Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2006-09-20T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy |
title |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy |
spellingShingle |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy Silva,Renata Lemos Partial Hepatectomy Liver Regeneration Sida cordifolia Medicinal Plant |
title_short |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy |
title_full |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy |
title_fullStr |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy |
title_full_unstemmed |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy |
title_sort |
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy |
author |
Silva,Renata Lemos |
author_facet |
Silva,Renata Lemos Melo,Gustavo Barreto de Melo,Valdinaldo Aragão de Antoniolli,Ângelo Roberto Michellone,Paulo Roberto Teixeira Zucoloto,Sérgio Picinato,Maria Aparecida Neves Cardoso Franco,Clarice Fleury Fina Mota,Gustavo de Assis Castro e Silva,Orlando de |
author_role |
author |
author2 |
Melo,Gustavo Barreto de Melo,Valdinaldo Aragão de Antoniolli,Ângelo Roberto Michellone,Paulo Roberto Teixeira Zucoloto,Sérgio Picinato,Maria Aparecida Neves Cardoso Franco,Clarice Fleury Fina Mota,Gustavo de Assis Castro e Silva,Orlando de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Renata Lemos Melo,Gustavo Barreto de Melo,Valdinaldo Aragão de Antoniolli,Ângelo Roberto Michellone,Paulo Roberto Teixeira Zucoloto,Sérgio Picinato,Maria Aparecida Neves Cardoso Franco,Clarice Fleury Fina Mota,Gustavo de Assis Castro e Silva,Orlando de |
dc.subject.por.fl_str_mv |
Partial Hepatectomy Liver Regeneration Sida cordifolia Medicinal Plant |
topic |
Partial Hepatectomy Liver Regeneration Sida cordifolia Medicinal Plant |
description |
PURPOSE: The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration. METHODS: Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67% partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody. RESULTS: Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively). CONCLUSION: The aqueous extract of Sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000700009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000700009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502006000700009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.21 suppl.1 2006 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
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1752126438235963392 |