Effects of thymoquinone against cisplatin-induced cardiac injury in rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400271 |
Resumo: | PURPOSE: T o investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury. METHODS: A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days). RESULTS: There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p<0.05). In only CP administered group, expression of antiapoptotic protein Bcl-2 was lowest comparing with other groups. CONCLUSION: Established data indicate that cisplatin is cardiotoxic and thymoquinone may be useful in treating CP-induced cardiac injury. |
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Effects of thymoquinone against cisplatin-induced cardiac injury in ratsCisplatinCardiotoxicityGenes, bcl-2Rats PURPOSE: T o investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury. METHODS: A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days). RESULTS: There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p<0.05). In only CP administered group, expression of antiapoptotic protein Bcl-2 was lowest comparing with other groups. CONCLUSION: Established data indicate that cisplatin is cardiotoxic and thymoquinone may be useful in treating CP-induced cardiac injury.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400271Acta Cirúrgica Brasileira v.31 n.4 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020160040000008info:eu-repo/semantics/openAccessAdalı,FahriGonul,YucelKocak,AhmetYuksel,YaseminOzkececi,GulayOzdemir,CigdemTunay,KamilBozkurt,Mehmet FatihSen,Ozlem Guleceng2016-05-06T00:00:00Zoai:scielo:S0102-86502016000400271Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2016-05-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats |
title |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats |
spellingShingle |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats Adalı,Fahri Cisplatin Cardiotoxicity Genes, bcl-2 Rats |
title_short |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats |
title_full |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats |
title_fullStr |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats |
title_full_unstemmed |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats |
title_sort |
Effects of thymoquinone against cisplatin-induced cardiac injury in rats |
author |
Adalı,Fahri |
author_facet |
Adalı,Fahri Gonul,Yucel Kocak,Ahmet Yuksel,Yasemin Ozkececi,Gulay Ozdemir,Cigdem Tunay,Kamil Bozkurt,Mehmet Fatih Sen,Ozlem Gulec |
author_role |
author |
author2 |
Gonul,Yucel Kocak,Ahmet Yuksel,Yasemin Ozkececi,Gulay Ozdemir,Cigdem Tunay,Kamil Bozkurt,Mehmet Fatih Sen,Ozlem Gulec |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Adalı,Fahri Gonul,Yucel Kocak,Ahmet Yuksel,Yasemin Ozkececi,Gulay Ozdemir,Cigdem Tunay,Kamil Bozkurt,Mehmet Fatih Sen,Ozlem Gulec |
dc.subject.por.fl_str_mv |
Cisplatin Cardiotoxicity Genes, bcl-2 Rats |
topic |
Cisplatin Cardiotoxicity Genes, bcl-2 Rats |
description |
PURPOSE: T o investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury. METHODS: A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days). RESULTS: There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p<0.05). In only CP administered group, expression of antiapoptotic protein Bcl-2 was lowest comparing with other groups. CONCLUSION: Established data indicate that cisplatin is cardiotoxic and thymoquinone may be useful in treating CP-induced cardiac injury. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400271 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400271 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-865020160040000008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.31 n.4 2016 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126443634032640 |