Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil

• Autor(a) principal: Cunha,Bruna Lais Almeida
• Data de Publicação: 2014
• Outros Autores: França,Jerônimo Pereira de, Moraes,Andrea Aparecida de Fátima Souza, Chaves,Alba Lucilvânia Fonseca, Gaiba,Silvana, Fontana,Renato, Sacramento,Celio Kersul do, Ferreira,Lydia Masako, França,Lucimar Pereira de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001400006
• topic: Garcinia mangostana L.; Drug Screening Assays, Antitumor; Anti-Infective Agents; Antimicrobial

PURPOSE: To characterize the anatomy of the fruit and leaf and the presence of phytocompounds. To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L. (mangosteen) cultivated in southeastern Brazil.METHODS: Anatomical characterization and histochemical reactions were performed for structural identification and the presence of phytocompounds. Preparation of ethanolic extract of the fruit, leaf and resin of mangosteen. Culture B16-F10 melanoma cells for treatment with mangosteen ethanolic extract to determine cell viability by MTT and genotoxic effect by comet assay. Evaluation by antimicrobial activity against Staphylococcus aureusand Escherichia coli by agar diffusion test and by determination of Minimum Inhibitory Concentration (MIC).RESULTS: Our results showed many secretory canals in resin fruit and leaf; identifying lipids, starch, lignin and phenolic compounds. The leaf extract induced genotoxicity and apoptosis in B16-F10 cells, since the fragmentation of DNA in the comet assay. The ethanolic extract of mangosteen obtained in the resin, leaf and fruit showed antimicrobial activity against Staphylococcus aureusand Escherichia coli with a MIC at 0.1 mg/mL.CONCLUSION:In conclusion, we have demonstrated both antimicrobial and antitumor activity of ethanol extract of mangosteen emphasizing its therapeutic potential in infectious diseases and in cancer, such as melanoma.