Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats

Detalhes bibliográficos
Autor(a) principal: Eken,Hüseyin
Data de Publicação: 2019
Outros Autores: Cimen,Orhan, Cimen,Ferda Keskin, Kurnaz,Eray, Yildirim,Murat, Tasova,Volkan, Kurt,Nezahat, Pehlivanoglu,Kamil, Onk,Didem, Bilgin,Asli Ozbek
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000400208
Resumo: Abstract Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.
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spelling Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in ratsTaxifolinCeliac ArteryIschemiaReperfusionRatsAbstract Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000400208Acta Cirúrgica Brasileira v.34 n.4 2019reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020190040000004info:eu-repo/semantics/openAccessEken,HüseyinCimen,OrhanCimen,Ferda KeskinKurnaz,ErayYildirim,MuratTasova,VolkanKurt,NezahatPehlivanoglu,KamilOnk,DidemBilgin,Asli Ozbekeng2019-04-30T00:00:00Zoai:scielo:S0102-86502019000400208Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2019-04-30T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
title Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
spellingShingle Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
Eken,Hüseyin
Taxifolin
Celiac Artery
Ischemia
Reperfusion
Rats
title_short Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
title_full Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
title_fullStr Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
title_full_unstemmed Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
title_sort Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
author Eken,Hüseyin
author_facet Eken,Hüseyin
Cimen,Orhan
Cimen,Ferda Keskin
Kurnaz,Eray
Yildirim,Murat
Tasova,Volkan
Kurt,Nezahat
Pehlivanoglu,Kamil
Onk,Didem
Bilgin,Asli Ozbek
author_role author
author2 Cimen,Orhan
Cimen,Ferda Keskin
Kurnaz,Eray
Yildirim,Murat
Tasova,Volkan
Kurt,Nezahat
Pehlivanoglu,Kamil
Onk,Didem
Bilgin,Asli Ozbek
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Eken,Hüseyin
Cimen,Orhan
Cimen,Ferda Keskin
Kurnaz,Eray
Yildirim,Murat
Tasova,Volkan
Kurt,Nezahat
Pehlivanoglu,Kamil
Onk,Didem
Bilgin,Asli Ozbek
dc.subject.por.fl_str_mv Taxifolin
Celiac Artery
Ischemia
Reperfusion
Rats
topic Taxifolin
Celiac Artery
Ischemia
Reperfusion
Rats
description Abstract Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000400208
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000400208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020190040000004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.34 n.4 2019
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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