Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats

Detalhes bibliográficos
Autor(a) principal: Melro,Ana Paula Campos
Data de Publicação: 2008
Outros Autores: Collares,Edgard Ferro, Silva,Joaquim Murray Bustorff
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600003
Resumo: PURPOSE: To evaluate the effect of hypoxic-ischemic brain injury over the gastric emptying of liquids in rats. METHODS: Fifty-two Wistar rats aged six weeks and weighing between 100g and 150g were divided in three groups. A Control group (C), a Sham group (S) undergoing sham procedure, and a Hypoxic-ischemic group (HI) consisting of 18 animals undergoing surgical ligature of the left carotid artery and exposure to hypoxic environment for three hours. Half of the animals were studied in the third day post-HI procedure (Early) and nine in the 14th day post-HI procedure (Late). Gastric emptying was evaluated by an infusion technique using fenolsulftalein as a marker. RESULTS: After the HI procedure, all animals displayed left eyelid ptosis, and six animals showed minor sideway gait. Histological examination confirmed de brain injury in all animals from the HI group. There was no statistical significant difference among the mean gastric retention values of the three groups neither in the Early nor in the Late evaluation. CONCLUSION: Isolated HI brain injury was not associated with delayed gastric emptying.
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spelling Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in ratsGastric EmptyingGastroesophageal RefluxSaline Solution, HypertonicRatsPURPOSE: To evaluate the effect of hypoxic-ischemic brain injury over the gastric emptying of liquids in rats. METHODS: Fifty-two Wistar rats aged six weeks and weighing between 100g and 150g were divided in three groups. A Control group (C), a Sham group (S) undergoing sham procedure, and a Hypoxic-ischemic group (HI) consisting of 18 animals undergoing surgical ligature of the left carotid artery and exposure to hypoxic environment for three hours. Half of the animals were studied in the third day post-HI procedure (Early) and nine in the 14th day post-HI procedure (Late). Gastric emptying was evaluated by an infusion technique using fenolsulftalein as a marker. RESULTS: After the HI procedure, all animals displayed left eyelid ptosis, and six animals showed minor sideway gait. Histological examination confirmed de brain injury in all animals from the HI group. There was no statistical significant difference among the mean gastric retention values of the three groups neither in the Early nor in the Late evaluation. CONCLUSION: Isolated HI brain injury was not associated with delayed gastric emptying.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600003Acta Cirúrgica Brasileira v.23 n.6 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000600003info:eu-repo/semantics/openAccessMelro,Ana Paula CamposCollares,Edgard FerroSilva,Joaquim Murray Bustorffeng2008-11-12T00:00:00Zoai:scielo:S0102-86502008000600003Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-11-12T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
title Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
spellingShingle Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
Melro,Ana Paula Campos
Gastric Emptying
Gastroesophageal Reflux
Saline Solution, Hypertonic
Rats
title_short Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
title_full Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
title_fullStr Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
title_full_unstemmed Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
title_sort Effect of an isolated mild to moderate ischemic brain injury in the gastric emptying of liquids in rats
author Melro,Ana Paula Campos
author_facet Melro,Ana Paula Campos
Collares,Edgard Ferro
Silva,Joaquim Murray Bustorff
author_role author
author2 Collares,Edgard Ferro
Silva,Joaquim Murray Bustorff
author2_role author
author
dc.contributor.author.fl_str_mv Melro,Ana Paula Campos
Collares,Edgard Ferro
Silva,Joaquim Murray Bustorff
dc.subject.por.fl_str_mv Gastric Emptying
Gastroesophageal Reflux
Saline Solution, Hypertonic
Rats
topic Gastric Emptying
Gastroesophageal Reflux
Saline Solution, Hypertonic
Rats
description PURPOSE: To evaluate the effect of hypoxic-ischemic brain injury over the gastric emptying of liquids in rats. METHODS: Fifty-two Wistar rats aged six weeks and weighing between 100g and 150g were divided in three groups. A Control group (C), a Sham group (S) undergoing sham procedure, and a Hypoxic-ischemic group (HI) consisting of 18 animals undergoing surgical ligature of the left carotid artery and exposure to hypoxic environment for three hours. Half of the animals were studied in the third day post-HI procedure (Early) and nine in the 14th day post-HI procedure (Late). Gastric emptying was evaluated by an infusion technique using fenolsulftalein as a marker. RESULTS: After the HI procedure, all animals displayed left eyelid ptosis, and six animals showed minor sideway gait. Histological examination confirmed de brain injury in all animals from the HI group. There was no statistical significant difference among the mean gastric retention values of the three groups neither in the Early nor in the Late evaluation. CONCLUSION: Isolated HI brain injury was not associated with delayed gastric emptying.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502008000600003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.23 n.6 2008
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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