Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400004 |
Resumo: | PURPOSE: To evaluate the effects of hyperbaric oxygen (HO) therapy in the protection against liver ischemia/reperfusion injury. METHODS: Thirty-two male Wistar rats were divided into four groups of eight animals each: group A - laparotomy and liver manipulation, group B - liver ischemia and reperfusion, group C - HO pretreatment for 60 min followed by liver ischemia and reperfusion, and group D - pretreatment with ambient air at 2.5 absolute atmospheres for 60 min followed by liver ischemia and reperfusion. Plasma was assayed for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). Intra-arterial blood pressure was monitored continuously. Myeloperoxidase activity in the liver and lung was assessed 30 min after reperfusion. RESULTS: Plasma AST, ALT and LDH increased after reperfusion in all animals. Plasma ALT values and myeloperoxidase activity in the liver parenchyma were higher in HO-pretreated animals than in groups A, B and D. HO had a negative hemodynamic effect during liver reperfusion. CONCLUSION: Liver preconditioning with hyperbaric oxygen therapy aggravated liver ischemia/reperfusion injury in rats as demonstrated by plasma ALT and liver myeloperoxidase activity. |
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Hyperbaric oxygen therapy aggravates liver reperfusion injury in ratsReperfusion InjuryLiverHyperbaric OxygenationRatsPURPOSE: To evaluate the effects of hyperbaric oxygen (HO) therapy in the protection against liver ischemia/reperfusion injury. METHODS: Thirty-two male Wistar rats were divided into four groups of eight animals each: group A - laparotomy and liver manipulation, group B - liver ischemia and reperfusion, group C - HO pretreatment for 60 min followed by liver ischemia and reperfusion, and group D - pretreatment with ambient air at 2.5 absolute atmospheres for 60 min followed by liver ischemia and reperfusion. Plasma was assayed for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). Intra-arterial blood pressure was monitored continuously. Myeloperoxidase activity in the liver and lung was assessed 30 min after reperfusion. RESULTS: Plasma AST, ALT and LDH increased after reperfusion in all animals. Plasma ALT values and myeloperoxidase activity in the liver parenchyma were higher in HO-pretreated animals than in groups A, B and D. HO had a negative hemodynamic effect during liver reperfusion. CONCLUSION: Liver preconditioning with hyperbaric oxygen therapy aggravated liver ischemia/reperfusion injury in rats as demonstrated by plasma ALT and liver myeloperoxidase activity.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400004Acta Cirúrgica Brasileira v.23 n.4 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000400004info:eu-repo/semantics/openAccessLima,Cristiano XavierSanches,Marcelo DiasRezende Neto,João Baptista deSilva,Roberto Carlos de Oliveira eTeixeira,Mauro MartinsSouza,Danielle da Glória deSantos,Guilherme de CastroMelo,José Renan da Cunhaeng2008-07-15T00:00:00Zoai:scielo:S0102-86502008000400004Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-07-15T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats |
title |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats |
spellingShingle |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats Lima,Cristiano Xavier Reperfusion Injury Liver Hyperbaric Oxygenation Rats |
title_short |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats |
title_full |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats |
title_fullStr |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats |
title_full_unstemmed |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats |
title_sort |
Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats |
author |
Lima,Cristiano Xavier |
author_facet |
Lima,Cristiano Xavier Sanches,Marcelo Dias Rezende Neto,João Baptista de Silva,Roberto Carlos de Oliveira e Teixeira,Mauro Martins Souza,Danielle da Glória de Santos,Guilherme de Castro Melo,José Renan da Cunha |
author_role |
author |
author2 |
Sanches,Marcelo Dias Rezende Neto,João Baptista de Silva,Roberto Carlos de Oliveira e Teixeira,Mauro Martins Souza,Danielle da Glória de Santos,Guilherme de Castro Melo,José Renan da Cunha |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima,Cristiano Xavier Sanches,Marcelo Dias Rezende Neto,João Baptista de Silva,Roberto Carlos de Oliveira e Teixeira,Mauro Martins Souza,Danielle da Glória de Santos,Guilherme de Castro Melo,José Renan da Cunha |
dc.subject.por.fl_str_mv |
Reperfusion Injury Liver Hyperbaric Oxygenation Rats |
topic |
Reperfusion Injury Liver Hyperbaric Oxygenation Rats |
description |
PURPOSE: To evaluate the effects of hyperbaric oxygen (HO) therapy in the protection against liver ischemia/reperfusion injury. METHODS: Thirty-two male Wistar rats were divided into four groups of eight animals each: group A - laparotomy and liver manipulation, group B - liver ischemia and reperfusion, group C - HO pretreatment for 60 min followed by liver ischemia and reperfusion, and group D - pretreatment with ambient air at 2.5 absolute atmospheres for 60 min followed by liver ischemia and reperfusion. Plasma was assayed for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). Intra-arterial blood pressure was monitored continuously. Myeloperoxidase activity in the liver and lung was assessed 30 min after reperfusion. RESULTS: Plasma AST, ALT and LDH increased after reperfusion in all animals. Plasma ALT values and myeloperoxidase activity in the liver parenchyma were higher in HO-pretreated animals than in groups A, B and D. HO had a negative hemodynamic effect during liver reperfusion. CONCLUSION: Liver preconditioning with hyperbaric oxygen therapy aggravated liver ischemia/reperfusion injury in rats as demonstrated by plasma ALT and liver myeloperoxidase activity. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502008000400004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.23 n.4 2008 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126439129350144 |