Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001200005 |
Resumo: | PURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME). METHODS: Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each: SHAM- surgical treatment alone; Bolus Control Group - 3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group - 3 mL- IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group - IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group - IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group - IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group - IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min. RESULTS: There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions. CONCLUSION: Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles. Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol. |
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Acta Cirúrgica Brasileira (Online) |
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Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbitsAnestheticsIntravenousPropofolSolventsInflammationMicroscopyRabittsPURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME). METHODS: Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each: SHAM- surgical treatment alone; Bolus Control Group - 3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group - 3 mL- IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group - IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group - IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group - IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group - IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min. RESULTS: There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions. CONCLUSION: Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles. Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001200005Acta Cirúrgica Brasileira v.28 n.12 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013001200005info:eu-repo/semantics/openAccessPaço,Cristian DurçoVane,Matheus FachiniAndrade,Rafael Bicarato deDomingues,Maria AparecidaCarvalho,Lidia Raquel deSantos,Daniela Carvalho dosTakahira,Regina KiomiModolo,Norma Sueli PinheiroVane,Luiz Antonioeng2013-12-04T00:00:00Zoai:scielo:S0102-86502013001200005Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-12-04T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits |
title |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits |
spellingShingle |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits Paço,Cristian Durço Anesthetics Intravenous Propofol Solvents Inflammation Microscopy Rabitts |
title_short |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits |
title_full |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits |
title_fullStr |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits |
title_full_unstemmed |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits |
title_sort |
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits |
author |
Paço,Cristian Durço |
author_facet |
Paço,Cristian Durço Vane,Matheus Fachini Andrade,Rafael Bicarato de Domingues,Maria Aparecida Carvalho,Lidia Raquel de Santos,Daniela Carvalho dos Takahira,Regina Kiomi Modolo,Norma Sueli Pinheiro Vane,Luiz Antonio |
author_role |
author |
author2 |
Vane,Matheus Fachini Andrade,Rafael Bicarato de Domingues,Maria Aparecida Carvalho,Lidia Raquel de Santos,Daniela Carvalho dos Takahira,Regina Kiomi Modolo,Norma Sueli Pinheiro Vane,Luiz Antonio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paço,Cristian Durço Vane,Matheus Fachini Andrade,Rafael Bicarato de Domingues,Maria Aparecida Carvalho,Lidia Raquel de Santos,Daniela Carvalho dos Takahira,Regina Kiomi Modolo,Norma Sueli Pinheiro Vane,Luiz Antonio |
dc.subject.por.fl_str_mv |
Anesthetics Intravenous Propofol Solvents Inflammation Microscopy Rabitts |
topic |
Anesthetics Intravenous Propofol Solvents Inflammation Microscopy Rabitts |
description |
PURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME). METHODS: Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each: SHAM- surgical treatment alone; Bolus Control Group - 3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group - 3 mL- IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group - IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group - IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group - IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group - IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min. RESULTS: There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions. CONCLUSION: Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles. Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502013001200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.28 n.12 2013 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
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1752126442155540480 |