Experimental model of traumatic ulcer in the cheek mucosa of rats

Detalhes bibliográficos
Autor(a) principal: Cavalcante,Galyléia Meneses
Data de Publicação: 2011
Outros Autores: Paula,Renata Janaína Sousa de, Souza,Leonardo Peres de, Sousa,Fabrício Bitu, Mota,Mário Rogério Lima, Alves,Ana Paula Negreiros Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000300012
Resumo: PURPOSE: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases. RESULTS: During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency posttest, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day. CONCLUSION: The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.
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spelling Experimental model of traumatic ulcer in the cheek mucosa of ratsUlcerMouth MucosaWound HelingRatsPURPOSE: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases. RESULTS: During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency posttest, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day. CONCLUSION: The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000300012Acta Cirúrgica Brasileira v.26 n.3 2011reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502011000300012info:eu-repo/semantics/openAccessCavalcante,Galyléia MenesesPaula,Renata Janaína Sousa deSouza,Leonardo Peres deSousa,Fabrício BituMota,Mário Rogério LimaAlves,Ana Paula Negreiros Nuneseng2011-04-20T00:00:00Zoai:scielo:S0102-86502011000300012Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2011-04-20T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Experimental model of traumatic ulcer in the cheek mucosa of rats
title Experimental model of traumatic ulcer in the cheek mucosa of rats
spellingShingle Experimental model of traumatic ulcer in the cheek mucosa of rats
Cavalcante,Galyléia Meneses
Ulcer
Mouth Mucosa
Wound Heling
Rats
title_short Experimental model of traumatic ulcer in the cheek mucosa of rats
title_full Experimental model of traumatic ulcer in the cheek mucosa of rats
title_fullStr Experimental model of traumatic ulcer in the cheek mucosa of rats
title_full_unstemmed Experimental model of traumatic ulcer in the cheek mucosa of rats
title_sort Experimental model of traumatic ulcer in the cheek mucosa of rats
author Cavalcante,Galyléia Meneses
author_facet Cavalcante,Galyléia Meneses
Paula,Renata Janaína Sousa de
Souza,Leonardo Peres de
Sousa,Fabrício Bitu
Mota,Mário Rogério Lima
Alves,Ana Paula Negreiros Nunes
author_role author
author2 Paula,Renata Janaína Sousa de
Souza,Leonardo Peres de
Sousa,Fabrício Bitu
Mota,Mário Rogério Lima
Alves,Ana Paula Negreiros Nunes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cavalcante,Galyléia Meneses
Paula,Renata Janaína Sousa de
Souza,Leonardo Peres de
Sousa,Fabrício Bitu
Mota,Mário Rogério Lima
Alves,Ana Paula Negreiros Nunes
dc.subject.por.fl_str_mv Ulcer
Mouth Mucosa
Wound Heling
Rats
topic Ulcer
Mouth Mucosa
Wound Heling
Rats
description PURPOSE: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases. RESULTS: During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency posttest, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day. CONCLUSION: The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000300012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000300012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502011000300012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.26 n.3 2011
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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