Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

Detalhes bibliográficos
Autor(a) principal: Girgin,Mustafa
Data de Publicação: 2016
Outros Autores: Binnetoglu,Kenan, Duman,Kazim, Kanat,Burhan Hakan, Cetinkaya,Ziya, Ayten,Refik, Ilhan,Yavuz Selim, Ilhan,Necip, Seker,Ibrahim, Timurkaan,Necati
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500314
Resumo: ABSTRACT PURPOSE : To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. METHODS: Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3. A fecal peritonitis was created following laparotomy and primary fascial repair and PRP treatment on the fascia was carried out on Group 4. RESULTS: TNF-α was found to be significantly lower in the control group (Group 1). It was detected at the highest level in the group in which fecal peritonitis was created and PRP applied (Group 4). TGF-β was determined as being significantly higher only in Group 4. Histopathologically, the differences between the groups in terms of cell infiltration and collagen deposition were not found to be significant. CONCLUSION: When platelet rich plasma was given histologically and biochemicaly as wound healing parameters cellular infiltration, collagen accumulation, and tissue hydroxyiproline levels were not increased but neovascularization, fibroblast activation and TNF Alfa levels were increased and PRP accelerated wound healing.
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spelling Effects of platelet rich plasma on fascial healing in rats with fecal peritonitisPlatelet-Rich PlasmaPeritonitisWound HealingRats.ABSTRACT PURPOSE : To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. METHODS: Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3. A fecal peritonitis was created following laparotomy and primary fascial repair and PRP treatment on the fascia was carried out on Group 4. RESULTS: TNF-α was found to be significantly lower in the control group (Group 1). It was detected at the highest level in the group in which fecal peritonitis was created and PRP applied (Group 4). TGF-β was determined as being significantly higher only in Group 4. Histopathologically, the differences between the groups in terms of cell infiltration and collagen deposition were not found to be significant. CONCLUSION: When platelet rich plasma was given histologically and biochemicaly as wound healing parameters cellular infiltration, collagen accumulation, and tissue hydroxyiproline levels were not increased but neovascularization, fibroblast activation and TNF Alfa levels were increased and PRP accelerated wound healing.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500314Acta Cirúrgica Brasileira v.31 n.5 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020160050000004info:eu-repo/semantics/openAccessGirgin,MustafaBinnetoglu,KenanDuman,KazimKanat,Burhan HakanCetinkaya,ZiyaAyten,RefikIlhan,Yavuz SelimIlhan,NecipSeker,IbrahimTimurkaan,Necatieng2016-06-03T00:00:00Zoai:scielo:S0102-86502016000500314Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2016-06-03T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
title Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
spellingShingle Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
Girgin,Mustafa
Platelet-Rich Plasma
Peritonitis
Wound Healing
Rats.
title_short Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
title_full Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
title_fullStr Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
title_full_unstemmed Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
title_sort Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
author Girgin,Mustafa
author_facet Girgin,Mustafa
Binnetoglu,Kenan
Duman,Kazim
Kanat,Burhan Hakan
Cetinkaya,Ziya
Ayten,Refik
Ilhan,Yavuz Selim
Ilhan,Necip
Seker,Ibrahim
Timurkaan,Necati
author_role author
author2 Binnetoglu,Kenan
Duman,Kazim
Kanat,Burhan Hakan
Cetinkaya,Ziya
Ayten,Refik
Ilhan,Yavuz Selim
Ilhan,Necip
Seker,Ibrahim
Timurkaan,Necati
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Girgin,Mustafa
Binnetoglu,Kenan
Duman,Kazim
Kanat,Burhan Hakan
Cetinkaya,Ziya
Ayten,Refik
Ilhan,Yavuz Selim
Ilhan,Necip
Seker,Ibrahim
Timurkaan,Necati
dc.subject.por.fl_str_mv Platelet-Rich Plasma
Peritonitis
Wound Healing
Rats.
topic Platelet-Rich Plasma
Peritonitis
Wound Healing
Rats.
description ABSTRACT PURPOSE : To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. METHODS: Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3. A fecal peritonitis was created following laparotomy and primary fascial repair and PRP treatment on the fascia was carried out on Group 4. RESULTS: TNF-α was found to be significantly lower in the control group (Group 1). It was detected at the highest level in the group in which fecal peritonitis was created and PRP applied (Group 4). TGF-β was determined as being significantly higher only in Group 4. Histopathologically, the differences between the groups in terms of cell infiltration and collagen deposition were not found to be significant. CONCLUSION: When platelet rich plasma was given histologically and biochemicaly as wound healing parameters cellular infiltration, collagen accumulation, and tissue hydroxyiproline levels were not increased but neovascularization, fibroblast activation and TNF Alfa levels were increased and PRP accelerated wound healing.
publishDate 2016
dc.date.none.fl_str_mv 2016-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500314
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500314
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-865020160050000004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.31 n.5 2016
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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