Tracheal suture in rats with hypothyroidism: wound healing study
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400007 |
Resumo: | PURPOSE: To evaluate the influence of hypothyroidism in tracheal wound healing process. METHODS: A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done. RESULTS: The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant. CONCLUSION: Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity. |
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Tracheal suture in rats with hypothyroidism: wound healing studyWound HealingHypothyroidismTracheaRatsPURPOSE: To evaluate the influence of hypothyroidism in tracheal wound healing process. METHODS: A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done. RESULTS: The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant. CONCLUSION: Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400007Acta Cirúrgica Brasileira v.24 n.4 2009reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502009000400007info:eu-repo/semantics/openAccessZimmermann,EliseRibas-Filho,Jurandir MarcondesMalafaia,OsvaldoRibas,Carmen Austrália Paredes MarcondesNassif,Paulo Afonso NunesStieven Filho,EdmarPrzysiezny,Paulo Eduardoeng2009-08-17T00:00:00Zoai:scielo:S0102-86502009000400007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2009-08-17T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Tracheal suture in rats with hypothyroidism: wound healing study |
title |
Tracheal suture in rats with hypothyroidism: wound healing study |
spellingShingle |
Tracheal suture in rats with hypothyroidism: wound healing study Zimmermann,Elise Wound Healing Hypothyroidism Trachea Rats |
title_short |
Tracheal suture in rats with hypothyroidism: wound healing study |
title_full |
Tracheal suture in rats with hypothyroidism: wound healing study |
title_fullStr |
Tracheal suture in rats with hypothyroidism: wound healing study |
title_full_unstemmed |
Tracheal suture in rats with hypothyroidism: wound healing study |
title_sort |
Tracheal suture in rats with hypothyroidism: wound healing study |
author |
Zimmermann,Elise |
author_facet |
Zimmermann,Elise Ribas-Filho,Jurandir Marcondes Malafaia,Osvaldo Ribas,Carmen Austrália Paredes Marcondes Nassif,Paulo Afonso Nunes Stieven Filho,Edmar Przysiezny,Paulo Eduardo |
author_role |
author |
author2 |
Ribas-Filho,Jurandir Marcondes Malafaia,Osvaldo Ribas,Carmen Austrália Paredes Marcondes Nassif,Paulo Afonso Nunes Stieven Filho,Edmar Przysiezny,Paulo Eduardo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Zimmermann,Elise Ribas-Filho,Jurandir Marcondes Malafaia,Osvaldo Ribas,Carmen Austrália Paredes Marcondes Nassif,Paulo Afonso Nunes Stieven Filho,Edmar Przysiezny,Paulo Eduardo |
dc.subject.por.fl_str_mv |
Wound Healing Hypothyroidism Trachea Rats |
topic |
Wound Healing Hypothyroidism Trachea Rats |
description |
PURPOSE: To evaluate the influence of hypothyroidism in tracheal wound healing process. METHODS: A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done. RESULTS: The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant. CONCLUSION: Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502009000400007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.24 n.4 2009 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126439583383552 |