Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000900593 |
Resumo: | PURPOSE:To compare histologically the action of Mitomycin C and that of Clobetasol propionate for surgical wound healing in rats.METHODS:A circular skin fragment was surgically removed from 57 Wistar rats. Twenty-two animals were treated with Mitomycin C with topical medication in a single dose, 22 with Clobetasol propionate with a cream medication once a day for 15 days and 13 did not receive any medication. The animals were euthanized 30 and 60 days, and the scars subjected to histological examination.RESULTS: The histological analysis on the samples did not show statistically significant differences regarding the quantities of fibroblasts, fibrocytes and vascular proliferation in the three groups, in the evaluations after 30 and 60 days. In the treated groups with Mitomycin C and Clobetasol there was a decrease in collagen concentration over the 30-day period and an increase in collagen concentration over the 60-day period, in comparison with the control group.CONCLUSIONS: The actions of Mitomycin C and Clobetasol were equivalent and not interfere in fibroplasias and in angiogenesis. Both drugs initially cause a decrease in collagen over a 30-day period and an increase over a 60-day period, demonstrating a delay in the wound healing. |
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Acta Cirúrgica Brasileira (Online) |
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Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionateWound HealingMitomycinPropionatesClobetasolCollagenModels, AnimalRats, WistarPURPOSE:To compare histologically the action of Mitomycin C and that of Clobetasol propionate for surgical wound healing in rats.METHODS:A circular skin fragment was surgically removed from 57 Wistar rats. Twenty-two animals were treated with Mitomycin C with topical medication in a single dose, 22 with Clobetasol propionate with a cream medication once a day for 15 days and 13 did not receive any medication. The animals were euthanized 30 and 60 days, and the scars subjected to histological examination.RESULTS: The histological analysis on the samples did not show statistically significant differences regarding the quantities of fibroblasts, fibrocytes and vascular proliferation in the three groups, in the evaluations after 30 and 60 days. In the treated groups with Mitomycin C and Clobetasol there was a decrease in collagen concentration over the 30-day period and an increase in collagen concentration over the 60-day period, in comparison with the control group.CONCLUSIONS: The actions of Mitomycin C and Clobetasol were equivalent and not interfere in fibroplasias and in angiogenesis. Both drugs initially cause a decrease in collagen over a 30-day period and an increase over a 60-day period, demonstrating a delay in the wound healing.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000900593Acta Cirúrgica Brasileira v.30 n.9 2015reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020150090000002info:eu-repo/semantics/openAccessCarvalho,Maria de Fátima Pereira dePereira,Celina Siqueira BarbosaFregnani,José HumbertoRibeiro,Fernando de Andrade Quintanilhaeng2015-10-06T00:00:00Zoai:scielo:S0102-86502015000900593Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate |
title |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate |
spellingShingle |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate Carvalho,Maria de Fátima Pereira de Wound Healing Mitomycin Propionates Clobetasol Collagen Models, Animal Rats, Wistar |
title_short |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate |
title_full |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate |
title_fullStr |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate |
title_full_unstemmed |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate |
title_sort |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate |
author |
Carvalho,Maria de Fátima Pereira de |
author_facet |
Carvalho,Maria de Fátima Pereira de Pereira,Celina Siqueira Barbosa Fregnani,José Humberto Ribeiro,Fernando de Andrade Quintanilha |
author_role |
author |
author2 |
Pereira,Celina Siqueira Barbosa Fregnani,José Humberto Ribeiro,Fernando de Andrade Quintanilha |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Carvalho,Maria de Fátima Pereira de Pereira,Celina Siqueira Barbosa Fregnani,José Humberto Ribeiro,Fernando de Andrade Quintanilha |
dc.subject.por.fl_str_mv |
Wound Healing Mitomycin Propionates Clobetasol Collagen Models, Animal Rats, Wistar |
topic |
Wound Healing Mitomycin Propionates Clobetasol Collagen Models, Animal Rats, Wistar |
description |
PURPOSE:To compare histologically the action of Mitomycin C and that of Clobetasol propionate for surgical wound healing in rats.METHODS:A circular skin fragment was surgically removed from 57 Wistar rats. Twenty-two animals were treated with Mitomycin C with topical medication in a single dose, 22 with Clobetasol propionate with a cream medication once a day for 15 days and 13 did not receive any medication. The animals were euthanized 30 and 60 days, and the scars subjected to histological examination.RESULTS: The histological analysis on the samples did not show statistically significant differences regarding the quantities of fibroblasts, fibrocytes and vascular proliferation in the three groups, in the evaluations after 30 and 60 days. In the treated groups with Mitomycin C and Clobetasol there was a decrease in collagen concentration over the 30-day period and an increase in collagen concentration over the 60-day period, in comparison with the control group.CONCLUSIONS: The actions of Mitomycin C and Clobetasol were equivalent and not interfere in fibroplasias and in angiogenesis. Both drugs initially cause a decrease in collagen over a 30-day period and an increase over a 60-day period, demonstrating a delay in the wound healing. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000900593 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000900593 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-865020150090000002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.30 n.9 2015 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126443228233728 |