Fibrosis in tubularized skin flaps in rats, using silicon catheters with two different degrees of flexibility: experimental model

• Autor(a) principal: Passos,Antonio Henrique Rodrigues dos
• Data de Publicação: 2008
• Outros Autores: Costa,Fernando, Marchese,Lúcio Tedesco, Guimarães,Sergio Augusto Catanzaro, Oreini,Wilson Aparecido
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000300005
• topic: Hypospadias; Surgical Flaps; Silicon; Fibrosis; Rats

PURPOSE: Microscopically evaluate the intensity of fibrosis in tubularized skin flaps on the back of Wistar rats, using silicon molds with different degrees of flexibility. METHODS: Twenty rats were submitted to three tubularized skin flaps on their backs. In two tubular flaps, we placed, as a mold, silicon catheters with different degrees of flexibility and removed them on the seventh day after the surgery. They were divided into two groups and euthanized, on the seventh and twenty-first days respectively after the surgery for the collection of the pieces, coloration with Masson tricromic, quantification of the area of each sample and comparison among the groups. RESULTS: Fibrosis was less intense on the tubular flaps where a catheter was not used as a mold. No significant difference was verified among the pieces with the silicon catheters, but there was a tendency of less fibrosis on the tubules with the most flexible catheter. CONCLUSION: There was no significant difference among the two catheter types. Fibrosis was less intense in the flaps where the mold was not used.