Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400003 |
Resumo: | PURPOSE: To investigate the effects of different conditions used during cardiopulmonary bypass (CPB) surgery on accompanying production of cytokine and nitric oxide (NO). METHODS: Patients undergoing CPB for the first time were prospectively enrolled and divided into two groups according to CPB parameters performed: i) normothermia (36.5-37°C) with blood cardioplegia (NB group, n=10) and ii) hypothermia (29-31°C) with crystalloid cardioplegia (HC group, n=10). Plasma samples obtained following intubation (baseline), during (5 and 30 min) and after (4 and 24 h) CPB were assayed for cytokines (ELISA) and NO metabolites (Griess reaction). RESULTS: Peak concentrations of interleukin (IL)-6 and IL-8 were reached at 4 h post CPB in both groups, but in the HC group those levels increased earlier and persisted for longer (24 h) compared to baseline (P < 0.05). IL-10 levels also increased at 4 h compared to baseline, but only significantly so in the HC group. NO metabolites were reduced in HC group at all time points compared to baseline (P < 0.05), while no significant differences were detected in the NB group. CONCLUSION: The association between increased systemic levels of cytokines and reduced NO production in the HC group suggests that different myocardial protection and/or perfusion temperature used during CPB may contribute to the extent of inflammatory response. |
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Acta Cirúrgica Brasileira (Online) |
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Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypassCardiopulmonary BypassMyocardiumPerfusionNitric OxideCytokinesPURPOSE: To investigate the effects of different conditions used during cardiopulmonary bypass (CPB) surgery on accompanying production of cytokine and nitric oxide (NO). METHODS: Patients undergoing CPB for the first time were prospectively enrolled and divided into two groups according to CPB parameters performed: i) normothermia (36.5-37°C) with blood cardioplegia (NB group, n=10) and ii) hypothermia (29-31°C) with crystalloid cardioplegia (HC group, n=10). Plasma samples obtained following intubation (baseline), during (5 and 30 min) and after (4 and 24 h) CPB were assayed for cytokines (ELISA) and NO metabolites (Griess reaction). RESULTS: Peak concentrations of interleukin (IL)-6 and IL-8 were reached at 4 h post CPB in both groups, but in the HC group those levels increased earlier and persisted for longer (24 h) compared to baseline (P < 0.05). IL-10 levels also increased at 4 h compared to baseline, but only significantly so in the HC group. NO metabolites were reduced in HC group at all time points compared to baseline (P < 0.05), while no significant differences were detected in the NB group. CONCLUSION: The association between increased systemic levels of cytokines and reduced NO production in the HC group suggests that different myocardial protection and/or perfusion temperature used during CPB may contribute to the extent of inflammatory response.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2007-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400003Acta Cirúrgica Brasileira v.22 n.4 2007reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502007000400003info:eu-repo/semantics/openAccessTavares-Murta,Beatriz MartinsCordeiro,Adriana OliveiraMurta,Eddie Fernando CandidoCunha,Fernando de QueirozBisinotto,Flora Margarida Barraeng2007-07-23T00:00:00Zoai:scielo:S0102-86502007000400003Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-07-23T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass |
title |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass |
spellingShingle |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass Tavares-Murta,Beatriz Martins Cardiopulmonary Bypass Myocardium Perfusion Nitric Oxide Cytokines |
title_short |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass |
title_full |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass |
title_fullStr |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass |
title_full_unstemmed |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass |
title_sort |
Effect of myocardial protection and perfusion temperature on production of cytokines and nitric oxide during cardiopulmonary bypass |
author |
Tavares-Murta,Beatriz Martins |
author_facet |
Tavares-Murta,Beatriz Martins Cordeiro,Adriana Oliveira Murta,Eddie Fernando Candido Cunha,Fernando de Queiroz Bisinotto,Flora Margarida Barra |
author_role |
author |
author2 |
Cordeiro,Adriana Oliveira Murta,Eddie Fernando Candido Cunha,Fernando de Queiroz Bisinotto,Flora Margarida Barra |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Tavares-Murta,Beatriz Martins Cordeiro,Adriana Oliveira Murta,Eddie Fernando Candido Cunha,Fernando de Queiroz Bisinotto,Flora Margarida Barra |
dc.subject.por.fl_str_mv |
Cardiopulmonary Bypass Myocardium Perfusion Nitric Oxide Cytokines |
topic |
Cardiopulmonary Bypass Myocardium Perfusion Nitric Oxide Cytokines |
description |
PURPOSE: To investigate the effects of different conditions used during cardiopulmonary bypass (CPB) surgery on accompanying production of cytokine and nitric oxide (NO). METHODS: Patients undergoing CPB for the first time were prospectively enrolled and divided into two groups according to CPB parameters performed: i) normothermia (36.5-37°C) with blood cardioplegia (NB group, n=10) and ii) hypothermia (29-31°C) with crystalloid cardioplegia (HC group, n=10). Plasma samples obtained following intubation (baseline), during (5 and 30 min) and after (4 and 24 h) CPB were assayed for cytokines (ELISA) and NO metabolites (Griess reaction). RESULTS: Peak concentrations of interleukin (IL)-6 and IL-8 were reached at 4 h post CPB in both groups, but in the HC group those levels increased earlier and persisted for longer (24 h) compared to baseline (P < 0.05). IL-10 levels also increased at 4 h compared to baseline, but only significantly so in the HC group. NO metabolites were reduced in HC group at all time points compared to baseline (P < 0.05), while no significant differences were detected in the NB group. CONCLUSION: The association between increased systemic levels of cytokines and reduced NO production in the HC group suggests that different myocardial protection and/or perfusion temperature used during CPB may contribute to the extent of inflammatory response. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502007000400003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.22 n.4 2007 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126438658539520 |