A novel model of distal colon cancer in athymic mice

Detalhes bibliográficos
Autor(a) principal: Priolli,Denise Gonçalves
Data de Publicação: 2012
Outros Autores: Abrantes,Ana Margarida, Neves,Silvia, Batista,Joana Neves, Cardinalli,Izilda Aparecida, Botelho,Maria Filomena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000600001
Resumo: PURPOSE: The present a novel adenocarcinoma model in athymic mice. METHODS: Seven athymic mice were used. Colon diversion and distal fistula were made. Adenocarcinoma cells were inoculated in the submucosa of fistula. Tumor growth was monitored daily. Scintigraphy with 99mTc-MIBI was performed to identify the tumor. RESULTS: The model of distal colon cancer is feasible. Tumor detection was possible by both, macroscopically and molecular imaging. All resections demonstrated poorly differentiated tumors. Colon obstruction occurred in one case, similarly to evolution in human tumors of distal colon. CONCLUSION: The proposed model of distal colon cancer is feasible, allows for easy monitoring of tumoral growth by both, macroscopically and molecular imaging, and is suitable for studying the evolution of tumor with implementation of cytotoxic therapy in vivo.
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spelling A novel model of distal colon cancer in athymic miceXenograft Model Antitumor Assays, Colorectal NeoplasmsRadionuclide ImagingTechnetium Tc 99m SestamibiMice, NudePURPOSE: The present a novel adenocarcinoma model in athymic mice. METHODS: Seven athymic mice were used. Colon diversion and distal fistula were made. Adenocarcinoma cells were inoculated in the submucosa of fistula. Tumor growth was monitored daily. Scintigraphy with 99mTc-MIBI was performed to identify the tumor. RESULTS: The model of distal colon cancer is feasible. Tumor detection was possible by both, macroscopically and molecular imaging. All resections demonstrated poorly differentiated tumors. Colon obstruction occurred in one case, similarly to evolution in human tumors of distal colon. CONCLUSION: The proposed model of distal colon cancer is feasible, allows for easy monitoring of tumoral growth by both, macroscopically and molecular imaging, and is suitable for studying the evolution of tumor with implementation of cytotoxic therapy in vivo.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000600001Acta Cirúrgica Brasileira v.27 n.6 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012000600001info:eu-repo/semantics/openAccessPriolli,Denise GonçalvesAbrantes,Ana MargaridaNeves,SilviaBatista,Joana NevesCardinalli,Izilda AparecidaBotelho,Maria Filomenaeng2012-06-04T00:00:00Zoai:scielo:S0102-86502012000600001Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-06-04T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv A novel model of distal colon cancer in athymic mice
title A novel model of distal colon cancer in athymic mice
spellingShingle A novel model of distal colon cancer in athymic mice
Priolli,Denise Gonçalves
Xenograft Model Antitumor Assays, Colorectal Neoplasms
Radionuclide Imaging
Technetium Tc 99m Sestamibi
Mice, Nude
title_short A novel model of distal colon cancer in athymic mice
title_full A novel model of distal colon cancer in athymic mice
title_fullStr A novel model of distal colon cancer in athymic mice
title_full_unstemmed A novel model of distal colon cancer in athymic mice
title_sort A novel model of distal colon cancer in athymic mice
author Priolli,Denise Gonçalves
author_facet Priolli,Denise Gonçalves
Abrantes,Ana Margarida
Neves,Silvia
Batista,Joana Neves
Cardinalli,Izilda Aparecida
Botelho,Maria Filomena
author_role author
author2 Abrantes,Ana Margarida
Neves,Silvia
Batista,Joana Neves
Cardinalli,Izilda Aparecida
Botelho,Maria Filomena
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Priolli,Denise Gonçalves
Abrantes,Ana Margarida
Neves,Silvia
Batista,Joana Neves
Cardinalli,Izilda Aparecida
Botelho,Maria Filomena
dc.subject.por.fl_str_mv Xenograft Model Antitumor Assays, Colorectal Neoplasms
Radionuclide Imaging
Technetium Tc 99m Sestamibi
Mice, Nude
topic Xenograft Model Antitumor Assays, Colorectal Neoplasms
Radionuclide Imaging
Technetium Tc 99m Sestamibi
Mice, Nude
description PURPOSE: The present a novel adenocarcinoma model in athymic mice. METHODS: Seven athymic mice were used. Colon diversion and distal fistula were made. Adenocarcinoma cells were inoculated in the submucosa of fistula. Tumor growth was monitored daily. Scintigraphy with 99mTc-MIBI was performed to identify the tumor. RESULTS: The model of distal colon cancer is feasible. Tumor detection was possible by both, macroscopically and molecular imaging. All resections demonstrated poorly differentiated tumors. Colon obstruction occurred in one case, similarly to evolution in human tumors of distal colon. CONCLUSION: The proposed model of distal colon cancer is feasible, allows for easy monitoring of tumoral growth by both, macroscopically and molecular imaging, and is suitable for studying the evolution of tumor with implementation of cytotoxic therapy in vivo.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000600001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000600001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502012000600001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.27 n.6 2012
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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