Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats

Detalhes bibliográficos
Autor(a) principal: Binotto,Juliane Peliçari
Data de Publicação: 2020
Outros Autores: Mendes,Larissa Giorgetti, Gaspi,Fernanda Oliveira de Gaspari, Esquisatto,Marcelo Augusto Marreto, Andrade,Thiago Antonio Moretti de, Mendonça,Fernanda Aparecida Sampaio, Santos,Gláucia Maria Tech
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000300201
Resumo: Abstract Purpose: To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats. Methods: Seventy-five rats were submitted to burn injury on their back skin: (C) untreated; (F) with daily topical application of S. dendroideum extract; (M) with electrospinning membranes of PLA; (MF10) with electrospinning membranes of PLA with 10% S. dendroideum extract; (MF25) with electrospinning membranes of PLA with 25% S. dendroideum extract. Tissue samples were taken after 2, 6 and 14 days of the burn injury and were subjected to histomorfometric analysis of quantification of fibroblasts, collagen fibers, blood vessels, and inflammatory infiltrate Results: The histomorphometric analysis showed an increase in the number of fibroblasts, collagen fibers and blood vessels in the burns treated with membranes of PLA, associated or not with the 10% and 25% extract. The extract of S. dendroideum promoted the increase of collagen fibers. Conclusion: The electrospinning PLA membrane, isolated or associated with the S. dendrodeum extract, favored the healing of burn injuries in this experimental model, with an increase of fibroblasts, collagen fibers, and blood vessels. S. dendroideum isolated only stimulated the collagenesis.
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spelling Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in ratsWound HealingBurnsPhytotherapySkinRatsAbstract Purpose: To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats. Methods: Seventy-five rats were submitted to burn injury on their back skin: (C) untreated; (F) with daily topical application of S. dendroideum extract; (M) with electrospinning membranes of PLA; (MF10) with electrospinning membranes of PLA with 10% S. dendroideum extract; (MF25) with electrospinning membranes of PLA with 25% S. dendroideum extract. Tissue samples were taken after 2, 6 and 14 days of the burn injury and were subjected to histomorfometric analysis of quantification of fibroblasts, collagen fibers, blood vessels, and inflammatory infiltrate Results: The histomorphometric analysis showed an increase in the number of fibroblasts, collagen fibers and blood vessels in the burns treated with membranes of PLA, associated or not with the 10% and 25% extract. The extract of S. dendroideum promoted the increase of collagen fibers. Conclusion: The electrospinning PLA membrane, isolated or associated with the S. dendrodeum extract, favored the healing of burn injuries in this experimental model, with an increase of fibroblasts, collagen fibers, and blood vessels. S. dendroideum isolated only stimulated the collagenesis.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000300201Acta Cirúrgica Brasileira v.35 n.3 2020reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020200030000002info:eu-repo/semantics/openAccessBinotto,Juliane PeliçariMendes,Larissa GiorgettiGaspi,Fernanda Oliveira de GaspariEsquisatto,Marcelo Augusto MarretoAndrade,Thiago Antonio Moretti deMendonça,Fernanda Aparecida SampaioSantos,Gláucia Maria Techeng2020-05-18T00:00:00Zoai:scielo:S0102-86502020000300201Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2020-05-18T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
title Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
spellingShingle Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
Binotto,Juliane Peliçari
Wound Healing
Burns
Phytotherapy
Skin
Rats
title_short Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
title_full Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
title_fullStr Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
title_full_unstemmed Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
title_sort Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
author Binotto,Juliane Peliçari
author_facet Binotto,Juliane Peliçari
Mendes,Larissa Giorgetti
Gaspi,Fernanda Oliveira de Gaspari
Esquisatto,Marcelo Augusto Marreto
Andrade,Thiago Antonio Moretti de
Mendonça,Fernanda Aparecida Sampaio
Santos,Gláucia Maria Tech
author_role author
author2 Mendes,Larissa Giorgetti
Gaspi,Fernanda Oliveira de Gaspari
Esquisatto,Marcelo Augusto Marreto
Andrade,Thiago Antonio Moretti de
Mendonça,Fernanda Aparecida Sampaio
Santos,Gláucia Maria Tech
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Binotto,Juliane Peliçari
Mendes,Larissa Giorgetti
Gaspi,Fernanda Oliveira de Gaspari
Esquisatto,Marcelo Augusto Marreto
Andrade,Thiago Antonio Moretti de
Mendonça,Fernanda Aparecida Sampaio
Santos,Gláucia Maria Tech
dc.subject.por.fl_str_mv Wound Healing
Burns
Phytotherapy
Skin
Rats
topic Wound Healing
Burns
Phytotherapy
Skin
Rats
description Abstract Purpose: To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats. Methods: Seventy-five rats were submitted to burn injury on their back skin: (C) untreated; (F) with daily topical application of S. dendroideum extract; (M) with electrospinning membranes of PLA; (MF10) with electrospinning membranes of PLA with 10% S. dendroideum extract; (MF25) with electrospinning membranes of PLA with 25% S. dendroideum extract. Tissue samples were taken after 2, 6 and 14 days of the burn injury and were subjected to histomorfometric analysis of quantification of fibroblasts, collagen fibers, blood vessels, and inflammatory infiltrate Results: The histomorphometric analysis showed an increase in the number of fibroblasts, collagen fibers and blood vessels in the burns treated with membranes of PLA, associated or not with the 10% and 25% extract. The extract of S. dendroideum promoted the increase of collagen fibers. Conclusion: The electrospinning PLA membrane, isolated or associated with the S. dendrodeum extract, favored the healing of burn injuries in this experimental model, with an increase of fibroblasts, collagen fibers, and blood vessels. S. dendroideum isolated only stimulated the collagenesis.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000300201
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000300201
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020200030000002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.35 n.3 2020
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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