Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice

Detalhes bibliográficos
Autor(a) principal: Lara,Alessandra Cerávolo
Data de Publicação: 2016
Outros Autores: Cândido,Eduardo Batista, Vidigal,Paula Vieira, Rocha,Ana Luiza Lunardi, Carvalho-Macedo,Alessandra Costa, Carneiro,Márcia Mendonça, Silva-Filho,Agnaldo Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400286
Resumo: PURPOSE: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-N-nitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz). Group III also received intramuscular injections of MPA (medroxy progesterone acetate) every four weeks, while group IV received oral doses of Ltz daily. At the end of 16 weeks, the animals were sacrificed, and blood samples were collected for the measurement of serum estradiol and progesterone levels. Uterine histological sections were made to evaluate the presence of endometrial proliferative lesions. Differences between groups were evaluated with student's t test, ANOVA and chi-square test. RESULTS: Groups ENU+EHB, ENU+EHB+MPA and ENU+EHB+Ltz showed varying degrees of endometrial hyperplasia. The incidence of hyperplasia in groups ENU+EHB and ENU+EHB+Ltz was higher and more severe than in group ENU+EHB+MPA. Control group showed lower levels of serum estradiol than the other groups. CONCLUSION: There was no evidence that letrozole could act as an antiestrogenic drug in the development of endometrial proliferative lesions.
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spelling Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in miceEndometrial HyperplasiaEstradiolProgesteroneMice PURPOSE: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-N-nitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz). Group III also received intramuscular injections of MPA (medroxy progesterone acetate) every four weeks, while group IV received oral doses of Ltz daily. At the end of 16 weeks, the animals were sacrificed, and blood samples were collected for the measurement of serum estradiol and progesterone levels. Uterine histological sections were made to evaluate the presence of endometrial proliferative lesions. Differences between groups were evaluated with student's t test, ANOVA and chi-square test. RESULTS: Groups ENU+EHB, ENU+EHB+MPA and ENU+EHB+Ltz showed varying degrees of endometrial hyperplasia. The incidence of hyperplasia in groups ENU+EHB and ENU+EHB+Ltz was higher and more severe than in group ENU+EHB+MPA. Control group showed lower levels of serum estradiol than the other groups. CONCLUSION: There was no evidence that letrozole could act as an antiestrogenic drug in the development of endometrial proliferative lesions.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400286Acta Cirúrgica Brasileira v.31 n.4 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020160040000010info:eu-repo/semantics/openAccessLara,Alessandra CerávoloCândido,Eduardo BatistaVidigal,Paula VieiraRocha,Ana Luiza LunardiCarvalho-Macedo,Alessandra CostaCarneiro,Márcia MendonçaSilva-Filho,Agnaldo Lopeseng2016-05-06T00:00:00Zoai:scielo:S0102-86502016000400286Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2016-05-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
title Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
spellingShingle Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
Lara,Alessandra Cerávolo
Endometrial Hyperplasia
Estradiol
Progesterone
Mice
title_short Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
title_full Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
title_fullStr Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
title_full_unstemmed Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
title_sort Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
author Lara,Alessandra Cerávolo
author_facet Lara,Alessandra Cerávolo
Cândido,Eduardo Batista
Vidigal,Paula Vieira
Rocha,Ana Luiza Lunardi
Carvalho-Macedo,Alessandra Costa
Carneiro,Márcia Mendonça
Silva-Filho,Agnaldo Lopes
author_role author
author2 Cândido,Eduardo Batista
Vidigal,Paula Vieira
Rocha,Ana Luiza Lunardi
Carvalho-Macedo,Alessandra Costa
Carneiro,Márcia Mendonça
Silva-Filho,Agnaldo Lopes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lara,Alessandra Cerávolo
Cândido,Eduardo Batista
Vidigal,Paula Vieira
Rocha,Ana Luiza Lunardi
Carvalho-Macedo,Alessandra Costa
Carneiro,Márcia Mendonça
Silva-Filho,Agnaldo Lopes
dc.subject.por.fl_str_mv Endometrial Hyperplasia
Estradiol
Progesterone
Mice
topic Endometrial Hyperplasia
Estradiol
Progesterone
Mice
description PURPOSE: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-N-nitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz). Group III also received intramuscular injections of MPA (medroxy progesterone acetate) every four weeks, while group IV received oral doses of Ltz daily. At the end of 16 weeks, the animals were sacrificed, and blood samples were collected for the measurement of serum estradiol and progesterone levels. Uterine histological sections were made to evaluate the presence of endometrial proliferative lesions. Differences between groups were evaluated with student's t test, ANOVA and chi-square test. RESULTS: Groups ENU+EHB, ENU+EHB+MPA and ENU+EHB+Ltz showed varying degrees of endometrial hyperplasia. The incidence of hyperplasia in groups ENU+EHB and ENU+EHB+Ltz was higher and more severe than in group ENU+EHB+MPA. Control group showed lower levels of serum estradiol than the other groups. CONCLUSION: There was no evidence that letrozole could act as an antiestrogenic drug in the development of endometrial proliferative lesions.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400286
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400286
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-865020160040000010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.31 n.4 2016
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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