Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001200012 |
Resumo: | PURPOSE: To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea. METHODS: A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administered via gavage on the 11th day of gestation. Cesarean section was performed on the 20th day of gestation. The newborns' livers were examined and any morphological-histological abnormalities were registered. The presence of megakaryocytes was quantified in 50 microscope fields, as the total number of these cells per mm². RESULTS: The entire experimental group presented abnormalities of embryonic formation, with musculoskeletal anomalies, digestive system anomalies, hepatic congestion and friability, hydrops and delayed intrauterine growth. The histopathological analysis showed that morphological-histological hepatic destructuring had occurred in all entire experimental with removal of the hepatic trabeculae and severe hepatic megakaryocytosis. The mean megakaryocyte density ranged from 107.9 to 114.2 per mm², and it was eight times greater than in the control group, thus characterizing a situation of extramedullary hematopoiesis. CONCLUSION: The fetal exposure to ethylenethiourea caused hepatic damage characterized by severe extramedullary hematopoiesis. |
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Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethioureaPesticidesEthylenethioureaLiverHematopoiesis, ExtramedullaryPregnancy, AnimalAnimals, NewbornRatsPURPOSE: To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea. METHODS: A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administered via gavage on the 11th day of gestation. Cesarean section was performed on the 20th day of gestation. The newborns' livers were examined and any morphological-histological abnormalities were registered. The presence of megakaryocytes was quantified in 50 microscope fields, as the total number of these cells per mm². RESULTS: The entire experimental group presented abnormalities of embryonic formation, with musculoskeletal anomalies, digestive system anomalies, hepatic congestion and friability, hydrops and delayed intrauterine growth. The histopathological analysis showed that morphological-histological hepatic destructuring had occurred in all entire experimental with removal of the hepatic trabeculae and severe hepatic megakaryocytosis. The mean megakaryocyte density ranged from 107.9 to 114.2 per mm², and it was eight times greater than in the control group, thus characterizing a situation of extramedullary hematopoiesis. CONCLUSION: The fetal exposure to ethylenethiourea caused hepatic damage characterized by severe extramedullary hematopoiesis.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001200012Acta Cirúrgica Brasileira v.27 n.12 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012001200012info:eu-repo/semantics/openAccessLemos,Patrícia Veruska Ribeiro BarbosaMartins,José LuizLemos,Sidney Pereira PintoSantos,Fernando Leandro dosSilva,Sílvio Romero Gonçalves eeng2012-11-29T00:00:00Zoai:scielo:S0102-86502012001200012Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-11-29T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea |
title |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea |
spellingShingle |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea Lemos,Patrícia Veruska Ribeiro Barbosa Pesticides Ethylenethiourea Liver Hematopoiesis, Extramedullary Pregnancy, Animal Animals, Newborn Rats |
title_short |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea |
title_full |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea |
title_fullStr |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea |
title_full_unstemmed |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea |
title_sort |
Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea |
author |
Lemos,Patrícia Veruska Ribeiro Barbosa |
author_facet |
Lemos,Patrícia Veruska Ribeiro Barbosa Martins,José Luiz Lemos,Sidney Pereira Pinto Santos,Fernando Leandro dos Silva,Sílvio Romero Gonçalves e |
author_role |
author |
author2 |
Martins,José Luiz Lemos,Sidney Pereira Pinto Santos,Fernando Leandro dos Silva,Sílvio Romero Gonçalves e |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lemos,Patrícia Veruska Ribeiro Barbosa Martins,José Luiz Lemos,Sidney Pereira Pinto Santos,Fernando Leandro dos Silva,Sílvio Romero Gonçalves e |
dc.subject.por.fl_str_mv |
Pesticides Ethylenethiourea Liver Hematopoiesis, Extramedullary Pregnancy, Animal Animals, Newborn Rats |
topic |
Pesticides Ethylenethiourea Liver Hematopoiesis, Extramedullary Pregnancy, Animal Animals, Newborn Rats |
description |
PURPOSE: To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea. METHODS: A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administered via gavage on the 11th day of gestation. Cesarean section was performed on the 20th day of gestation. The newborns' livers were examined and any morphological-histological abnormalities were registered. The presence of megakaryocytes was quantified in 50 microscope fields, as the total number of these cells per mm². RESULTS: The entire experimental group presented abnormalities of embryonic formation, with musculoskeletal anomalies, digestive system anomalies, hepatic congestion and friability, hydrops and delayed intrauterine growth. The histopathological analysis showed that morphological-histological hepatic destructuring had occurred in all entire experimental with removal of the hepatic trabeculae and severe hepatic megakaryocytosis. The mean megakaryocyte density ranged from 107.9 to 114.2 per mm², and it was eight times greater than in the control group, thus characterizing a situation of extramedullary hematopoiesis. CONCLUSION: The fetal exposure to ethylenethiourea caused hepatic damage characterized by severe extramedullary hematopoiesis. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001200012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001200012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502012001200012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.27 n.12 2012 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126441401614336 |