Effects of sildenafil on the viability of random skin flaps

Detalhes bibliográficos
Autor(a) principal: Barral,Sumara Marques
Data de Publicação: 2011
Outros Autores: Araujo,Ivana Duval, Vidigal,Paula Vieira Teixeira, Mayrink,Cláudio Alvarenga Campos, Araujo,Adriana Duval, Costa,Paulo Roberto da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400012
Resumo: PURPOSE: To assess the viability of McFarlane skin flaps in rats with administration of sildenafil. METHODS: Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they were analyzed with AutoCAD software. Three biopsies (proximal, medial and distal) of each flap were collected for histological analysis. RESULTS: Macroscopic analysis showed that animals of the study group had greater necrotic areas (p=0.003) in the dorsal skin flaps. Additionally, histological analysis of the distal third of these flaps showed a tendency to less granulated tissue formation in animals treated with sildenafil. CONCLUSION: Sildenafil subdermally was associated with lower viability of the random skin flap in rats.
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spelling Effects of sildenafil on the viability of random skin flapsWound HealingSurgical FlapsCyclic GMPNitric OxideRatsPURPOSE: To assess the viability of McFarlane skin flaps in rats with administration of sildenafil. METHODS: Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they were analyzed with AutoCAD software. Three biopsies (proximal, medial and distal) of each flap were collected for histological analysis. RESULTS: Macroscopic analysis showed that animals of the study group had greater necrotic areas (p=0.003) in the dorsal skin flaps. Additionally, histological analysis of the distal third of these flaps showed a tendency to less granulated tissue formation in animals treated with sildenafil. CONCLUSION: Sildenafil subdermally was associated with lower viability of the random skin flap in rats.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400012Acta Cirúrgica Brasileira v.26 n.4 2011reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502011000400012info:eu-repo/semantics/openAccessBarral,Sumara MarquesAraujo,Ivana DuvalVidigal,Paula Vieira TeixeiraMayrink,Cláudio Alvarenga CamposAraujo,Adriana DuvalCosta,Paulo Roberto daeng2011-07-25T00:00:00Zoai:scielo:S0102-86502011000400012Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2011-07-25T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effects of sildenafil on the viability of random skin flaps
title Effects of sildenafil on the viability of random skin flaps
spellingShingle Effects of sildenafil on the viability of random skin flaps
Barral,Sumara Marques
Wound Healing
Surgical Flaps
Cyclic GMP
Nitric Oxide
Rats
title_short Effects of sildenafil on the viability of random skin flaps
title_full Effects of sildenafil on the viability of random skin flaps
title_fullStr Effects of sildenafil on the viability of random skin flaps
title_full_unstemmed Effects of sildenafil on the viability of random skin flaps
title_sort Effects of sildenafil on the viability of random skin flaps
author Barral,Sumara Marques
author_facet Barral,Sumara Marques
Araujo,Ivana Duval
Vidigal,Paula Vieira Teixeira
Mayrink,Cláudio Alvarenga Campos
Araujo,Adriana Duval
Costa,Paulo Roberto da
author_role author
author2 Araujo,Ivana Duval
Vidigal,Paula Vieira Teixeira
Mayrink,Cláudio Alvarenga Campos
Araujo,Adriana Duval
Costa,Paulo Roberto da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Barral,Sumara Marques
Araujo,Ivana Duval
Vidigal,Paula Vieira Teixeira
Mayrink,Cláudio Alvarenga Campos
Araujo,Adriana Duval
Costa,Paulo Roberto da
dc.subject.por.fl_str_mv Wound Healing
Surgical Flaps
Cyclic GMP
Nitric Oxide
Rats
topic Wound Healing
Surgical Flaps
Cyclic GMP
Nitric Oxide
Rats
description PURPOSE: To assess the viability of McFarlane skin flaps in rats with administration of sildenafil. METHODS: Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they were analyzed with AutoCAD software. Three biopsies (proximal, medial and distal) of each flap were collected for histological analysis. RESULTS: Macroscopic analysis showed that animals of the study group had greater necrotic areas (p=0.003) in the dorsal skin flaps. Additionally, histological analysis of the distal third of these flaps showed a tendency to less granulated tissue formation in animals treated with sildenafil. CONCLUSION: Sildenafil subdermally was associated with lower viability of the random skin flap in rats.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502011000400012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.26 n.4 2011
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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