THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000400011 |
Resumo: | The scorpion toxin induces a number of physiological parameters alterations, as disturbance of cardiac rhythm, heart failure, shock, pancreatic hypersecretion, abortion, respiratory arrhytmias and pulmonary edema. As the purification of the venom fractions is a laborious process, one alternative for this would be the utilization of small animals. We utilized in the present study thity-six mice that received progressive doses of scorpion toxin TsTX), i.p. or i.v., and were observed for three hours or sacrificed, and the pulmonary alterations were determined by the lung-body index and by histological analysis of the lungs in order to determine if the mouse can be an esperimental model for scorpion envenomation. The data were analyzed by One Way analysis of variance with p<0,05 indicating significance. These experiments showed no differences in clinical signs of scorpion envenomation between mice and other mammalians, the effects were dose-dependent and the i.v. administration needed less quantity to produce the same changings. In the pulmonary histology we observed septal but not alveolar edema, and we presumed that these differences are due to species-specific variations. |
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THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMINGScorpion toxinScorpion envenomationExperimental model for intoxicationThe scorpion toxin induces a number of physiological parameters alterations, as disturbance of cardiac rhythm, heart failure, shock, pancreatic hypersecretion, abortion, respiratory arrhytmias and pulmonary edema. As the purification of the venom fractions is a laborious process, one alternative for this would be the utilization of small animals. We utilized in the present study thity-six mice that received progressive doses of scorpion toxin TsTX), i.p. or i.v., and were observed for three hours or sacrificed, and the pulmonary alterations were determined by the lung-body index and by histological analysis of the lungs in order to determine if the mouse can be an esperimental model for scorpion envenomation. The data were analyzed by One Way analysis of variance with p<0,05 indicating significance. These experiments showed no differences in clinical signs of scorpion envenomation between mice and other mammalians, the effects were dose-dependent and the i.v. administration needed less quantity to produce the same changings. In the pulmonary histology we observed septal but not alveolar edema, and we presumed that these differences are due to species-specific variations.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia1998-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000400011Acta Cirúrgica Brasileira v.13 n.4 1998reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86501998000400011info:eu-repo/semantics/openAccessMagalhães,Mônica de MônicoViana,GiseleArantes,Rosa Maria EstevesSantos,Tasso MoraesCunha-Melo,José Renaneng1999-01-14T00:00:00Zoai:scielo:S0102-86501998000400011Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:1999-01-14T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING |
title |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING |
spellingShingle |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING Magalhães,Mônica de Mônico Scorpion toxin Scorpion envenomation Experimental model for intoxication |
title_short |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING |
title_full |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING |
title_fullStr |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING |
title_full_unstemmed |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING |
title_sort |
THE MOUSE AS AN EXPERIMENTAL MODEL FOR TITYUS SERRULATUS SCORPION ENVENOMING |
author |
Magalhães,Mônica de Mônico |
author_facet |
Magalhães,Mônica de Mônico Viana,Gisele Arantes,Rosa Maria Esteves Santos,Tasso Moraes Cunha-Melo,José Renan |
author_role |
author |
author2 |
Viana,Gisele Arantes,Rosa Maria Esteves Santos,Tasso Moraes Cunha-Melo,José Renan |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Magalhães,Mônica de Mônico Viana,Gisele Arantes,Rosa Maria Esteves Santos,Tasso Moraes Cunha-Melo,José Renan |
dc.subject.por.fl_str_mv |
Scorpion toxin Scorpion envenomation Experimental model for intoxication |
topic |
Scorpion toxin Scorpion envenomation Experimental model for intoxication |
description |
The scorpion toxin induces a number of physiological parameters alterations, as disturbance of cardiac rhythm, heart failure, shock, pancreatic hypersecretion, abortion, respiratory arrhytmias and pulmonary edema. As the purification of the venom fractions is a laborious process, one alternative for this would be the utilization of small animals. We utilized in the present study thity-six mice that received progressive doses of scorpion toxin TsTX), i.p. or i.v., and were observed for three hours or sacrificed, and the pulmonary alterations were determined by the lung-body index and by histological analysis of the lungs in order to determine if the mouse can be an esperimental model for scorpion envenomation. The data were analyzed by One Way analysis of variance with p<0,05 indicating significance. These experiments showed no differences in clinical signs of scorpion envenomation between mice and other mammalians, the effects were dose-dependent and the i.v. administration needed less quantity to produce the same changings. In the pulmonary histology we observed septal but not alveolar edema, and we presumed that these differences are due to species-specific variations. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000400011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000400011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86501998000400011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.13 n.4 1998 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126435124838400 |