Deleterious effects of prepubertal corticosterone treatment on rat prostate

Detalhes bibliográficos
Autor(a) principal: Pinto,Flávia Cristina Morone
Data de Publicação: 2015
Outros Autores: Silva,Dílson, Silva,Pamella Campos, Pereira,Luiza Morone, Morone,Arlene Regina, Costa,Waldemar Silva, Cortez,Célia Martins, Sampaio,Francisco José Barcellos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600382
Resumo: PURPOSE:To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase.METHODS:Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis.RESULTS:Acini distribution in the group treated with CORT differed significantly (p<0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p<0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897).CONCLUSION:Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone.
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spelling Deleterious effects of prepubertal corticosterone treatment on rat prostateCorticosteroneGlucocorticoidsProstateAnatomy &amp; HistologyRatsPURPOSE:To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase.METHODS:Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis.RESULTS:Acini distribution in the group treated with CORT differed significantly (p<0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p<0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897).CONCLUSION:Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600382Acta Cirúrgica Brasileira v.30 n.6 2015reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020150060000002info:eu-repo/semantics/openAccessPinto,Flávia Cristina MoroneSilva,DílsonSilva,Pamella CamposPereira,Luiza MoroneMorone,Arlene ReginaCosta,Waldemar SilvaCortez,Célia MartinsSampaio,Francisco José Barcelloseng2015-10-08T00:00:00Zoai:scielo:S0102-86502015000600382Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Deleterious effects of prepubertal corticosterone treatment on rat prostate
title Deleterious effects of prepubertal corticosterone treatment on rat prostate
spellingShingle Deleterious effects of prepubertal corticosterone treatment on rat prostate
Pinto,Flávia Cristina Morone
Corticosterone
Glucocorticoids
Prostate
Anatomy &amp; Histology
Rats
title_short Deleterious effects of prepubertal corticosterone treatment on rat prostate
title_full Deleterious effects of prepubertal corticosterone treatment on rat prostate
title_fullStr Deleterious effects of prepubertal corticosterone treatment on rat prostate
title_full_unstemmed Deleterious effects of prepubertal corticosterone treatment on rat prostate
title_sort Deleterious effects of prepubertal corticosterone treatment on rat prostate
author Pinto,Flávia Cristina Morone
author_facet Pinto,Flávia Cristina Morone
Silva,Dílson
Silva,Pamella Campos
Pereira,Luiza Morone
Morone,Arlene Regina
Costa,Waldemar Silva
Cortez,Célia Martins
Sampaio,Francisco José Barcellos
author_role author
author2 Silva,Dílson
Silva,Pamella Campos
Pereira,Luiza Morone
Morone,Arlene Regina
Costa,Waldemar Silva
Cortez,Célia Martins
Sampaio,Francisco José Barcellos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto,Flávia Cristina Morone
Silva,Dílson
Silva,Pamella Campos
Pereira,Luiza Morone
Morone,Arlene Regina
Costa,Waldemar Silva
Cortez,Célia Martins
Sampaio,Francisco José Barcellos
dc.subject.por.fl_str_mv Corticosterone
Glucocorticoids
Prostate
Anatomy &amp; Histology
Rats
topic Corticosterone
Glucocorticoids
Prostate
Anatomy &amp; Histology
Rats
description PURPOSE:To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase.METHODS:Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis.RESULTS:Acini distribution in the group treated with CORT differed significantly (p<0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p<0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897).CONCLUSION:Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600382
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600382
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-865020150060000002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.30 n.6 2015
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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