Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400362 |
Resumo: | Abstract Purpose: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). Methods: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. Results: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group. While the prophylaxis group and the treatment group had significantly lower scores. High-dose group showed similar results as prophylaxis group. Histopathological findings of the prophylaxis group was more significant than the treatment group. Immunoreactivities of IL-1β, FGF-2, TNF- α and HIF-1α increased in the control group especially in the epithelial and cryptic regions. On the contrary, sildenafil application caused significant decreases of inflammatory markers in all treatment groups, specifically better results in the prophylaxis group. Conclusion: The sildenafil has anti-inflammatory effects on ARP, as well as protective effects against ARP and the protective effect of sildenafil surpasses its therapeutic effect histopathologically. |
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Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in ratsSildenafil CitrateProctitisInflammationUltrastructureRats.Abstract Purpose: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). Methods: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. Results: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group. While the prophylaxis group and the treatment group had significantly lower scores. High-dose group showed similar results as prophylaxis group. Histopathological findings of the prophylaxis group was more significant than the treatment group. Immunoreactivities of IL-1β, FGF-2, TNF- α and HIF-1α increased in the control group especially in the epithelial and cryptic regions. On the contrary, sildenafil application caused significant decreases of inflammatory markers in all treatment groups, specifically better results in the prophylaxis group. Conclusion: The sildenafil has anti-inflammatory effects on ARP, as well as protective effects against ARP and the protective effect of sildenafil surpasses its therapeutic effect histopathologically.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2018-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400362Acta Cirúrgica Brasileira v.33 n.4 2018reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020180040000008info:eu-repo/semantics/openAccessYavuz,ErkanErcan,GulcinKaragulle,Onur OlgacBayrak,Busra YaprakBiricik,AytacErcetin,CandasGokcek,BerkYigitbas,HakanKusaslan,RamazanCelik,AtillaGulcicek,Osman Bilgineng2018-05-10T00:00:00Zoai:scielo:S0102-86502018000400362Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2018-05-10T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats |
title |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats |
spellingShingle |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats Yavuz,Erkan Sildenafil Citrate Proctitis Inflammation Ultrastructure Rats. |
title_short |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats |
title_full |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats |
title_fullStr |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats |
title_full_unstemmed |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats |
title_sort |
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats |
author |
Yavuz,Erkan |
author_facet |
Yavuz,Erkan Ercan,Gulcin Karagulle,Onur Olgac Bayrak,Busra Yaprak Biricik,Aytac Ercetin,Candas Gokcek,Berk Yigitbas,Hakan Kusaslan,Ramazan Celik,Atilla Gulcicek,Osman Bilgin |
author_role |
author |
author2 |
Ercan,Gulcin Karagulle,Onur Olgac Bayrak,Busra Yaprak Biricik,Aytac Ercetin,Candas Gokcek,Berk Yigitbas,Hakan Kusaslan,Ramazan Celik,Atilla Gulcicek,Osman Bilgin |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Yavuz,Erkan Ercan,Gulcin Karagulle,Onur Olgac Bayrak,Busra Yaprak Biricik,Aytac Ercetin,Candas Gokcek,Berk Yigitbas,Hakan Kusaslan,Ramazan Celik,Atilla Gulcicek,Osman Bilgin |
dc.subject.por.fl_str_mv |
Sildenafil Citrate Proctitis Inflammation Ultrastructure Rats. |
topic |
Sildenafil Citrate Proctitis Inflammation Ultrastructure Rats. |
description |
Abstract Purpose: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). Methods: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. Results: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group. While the prophylaxis group and the treatment group had significantly lower scores. High-dose group showed similar results as prophylaxis group. Histopathological findings of the prophylaxis group was more significant than the treatment group. Immunoreactivities of IL-1β, FGF-2, TNF- α and HIF-1α increased in the control group especially in the epithelial and cryptic regions. On the contrary, sildenafil application caused significant decreases of inflammatory markers in all treatment groups, specifically better results in the prophylaxis group. Conclusion: The sildenafil has anti-inflammatory effects on ARP, as well as protective effects against ARP and the protective effect of sildenafil surpasses its therapeutic effect histopathologically. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400362 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400362 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020180040000008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.33 n.4 2018 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126444881838080 |