Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark

Detalhes bibliográficos
Autor(a) principal: Leite,Gerlânia de Oliveira
Data de Publicação: 2011
Outros Autores: Sampaio,Renata Souza, Leite,Laura Hévila Inocêncio, Menezes,Irwin Rose Alencar de, Costa,José Galberto Martins da, Campos,Adriana Rolim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Dor
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-00132011000100010
Resumo: BACKGROUND AND OBJECTIVES: Vanillosmopsis arborea Baker (Asteraceae) has high economic value and anti-inflammatory properties due the presence of alpha-bisabolol in its bark essential oil. Keeping in view the high content of α-bisabolol in Vanillosmopsis arborea (EOVA) bark essential oil, the aim of our study was to determine whether EOVA mitigates viscer METHOD: Mice (n = 8) were pretreated orally with EOVA (100, 200 e 400 mg/kg) or vehicle, and pain-related behavioral responses to intraperitoneal cyclophosphamide (CPM 400 mg/kg), intracolonic mustard oil (MO 0.75%) or capsaicin (CAP 0.3%) were analyzed. RESULTS: Animals that received CFM, OM or CAP presented spontaneous nociceptive behaviors that were significantly suppressed by EOVA. CONCLUSION: These findings point to visceral antinociceptive properties of EOVA suggesting the potential use of Vanillosmopsis arborea to treat pain associated to gastrointestinal disorders.
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spelling Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea barkEssential oilVanillosmopsis arboreaVisceral painBACKGROUND AND OBJECTIVES: Vanillosmopsis arborea Baker (Asteraceae) has high economic value and anti-inflammatory properties due the presence of alpha-bisabolol in its bark essential oil. Keeping in view the high content of α-bisabolol in Vanillosmopsis arborea (EOVA) bark essential oil, the aim of our study was to determine whether EOVA mitigates viscer METHOD: Mice (n = 8) were pretreated orally with EOVA (100, 200 e 400 mg/kg) or vehicle, and pain-related behavioral responses to intraperitoneal cyclophosphamide (CPM 400 mg/kg), intracolonic mustard oil (MO 0.75%) or capsaicin (CAP 0.3%) were analyzed. RESULTS: Animals that received CFM, OM or CAP presented spontaneous nociceptive behaviors that were significantly suppressed by EOVA. CONCLUSION: These findings point to visceral antinociceptive properties of EOVA suggesting the potential use of Vanillosmopsis arborea to treat pain associated to gastrointestinal disorders.Sociedade Brasileira para o Estudo da Dor2011-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-00132011000100010Revista Dor v.12 n.1 2011reponame:Revista Dorinstname:Sociedade Brasileira para o Estudo da Dor (SBED)instacron:SBED10.1590/S1806-00132011000100010info:eu-repo/semantics/openAccessLeite,Gerlânia de OliveiraSampaio,Renata SouzaLeite,Laura Hévila InocêncioMenezes,Irwin Rose Alencar deCosta,José Galberto Martins daCampos,Adriana Rolimeng2011-09-28T00:00:00Zoai:scielo:S1806-00132011000100010Revistahttps://www.scielo.br/j/rdor/ONGhttps://old.scielo.br/oai/scielo-oai.phpdor@dor.org.br||dor@dor.org.br2317-63931806-0013opendoar:2011-09-28T00:00Revista Dor - Sociedade Brasileira para o Estudo da Dor (SBED)false
dc.title.none.fl_str_mv Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
title Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
spellingShingle Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
Leite,Gerlânia de Oliveira
Essential oil
Vanillosmopsis arborea
Visceral pain
title_short Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
title_full Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
title_fullStr Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
title_full_unstemmed Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
title_sort Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
author Leite,Gerlânia de Oliveira
author_facet Leite,Gerlânia de Oliveira
Sampaio,Renata Souza
Leite,Laura Hévila Inocêncio
Menezes,Irwin Rose Alencar de
Costa,José Galberto Martins da
Campos,Adriana Rolim
author_role author
author2 Sampaio,Renata Souza
Leite,Laura Hévila Inocêncio
Menezes,Irwin Rose Alencar de
Costa,José Galberto Martins da
Campos,Adriana Rolim
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Leite,Gerlânia de Oliveira
Sampaio,Renata Souza
Leite,Laura Hévila Inocêncio
Menezes,Irwin Rose Alencar de
Costa,José Galberto Martins da
Campos,Adriana Rolim
dc.subject.por.fl_str_mv Essential oil
Vanillosmopsis arborea
Visceral pain
topic Essential oil
Vanillosmopsis arborea
Visceral pain
description BACKGROUND AND OBJECTIVES: Vanillosmopsis arborea Baker (Asteraceae) has high economic value and anti-inflammatory properties due the presence of alpha-bisabolol in its bark essential oil. Keeping in view the high content of α-bisabolol in Vanillosmopsis arborea (EOVA) bark essential oil, the aim of our study was to determine whether EOVA mitigates viscer METHOD: Mice (n = 8) were pretreated orally with EOVA (100, 200 e 400 mg/kg) or vehicle, and pain-related behavioral responses to intraperitoneal cyclophosphamide (CPM 400 mg/kg), intracolonic mustard oil (MO 0.75%) or capsaicin (CAP 0.3%) were analyzed. RESULTS: Animals that received CFM, OM or CAP presented spontaneous nociceptive behaviors that were significantly suppressed by EOVA. CONCLUSION: These findings point to visceral antinociceptive properties of EOVA suggesting the potential use of Vanillosmopsis arborea to treat pain associated to gastrointestinal disorders.
publishDate 2011
dc.date.none.fl_str_mv 2011-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-00132011000100010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-00132011000100010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1806-00132011000100010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Estudo da Dor
publisher.none.fl_str_mv Sociedade Brasileira para o Estudo da Dor
dc.source.none.fl_str_mv Revista Dor v.12 n.1 2011
reponame:Revista Dor
instname:Sociedade Brasileira para o Estudo da Dor (SBED)
instacron:SBED
instname_str Sociedade Brasileira para o Estudo da Dor (SBED)
instacron_str SBED
institution SBED
reponame_str Revista Dor
collection Revista Dor
repository.name.fl_str_mv Revista Dor - Sociedade Brasileira para o Estudo da Dor (SBED)
repository.mail.fl_str_mv dor@dor.org.br||dor@dor.org.br
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