Systemic alterations in plasma biomarkers levels in patients with chronic pain
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | BrJP (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922019000300274 |
Resumo: | ABSTRACT BACKGROUND AND OBJECTIVES: To analyze the scientific evidence on the changes in plasma levels of interleukins, nitric oxide, extracellular matrix metalloproteinases, bradykinins, and cortisol in patients with chronic pain. CONTENTS: The studies were identified by searching the following electronic databases: Pubmed/Medline, Scopus, LILACS, and Web of Science, published from June of 2016 to December of 2016. The selected articles were presented in a flow chart based on their identification, selection, eligibility and inclusion and exclusion criteria. The content of the articles included in the study was analyzed to identify the biomarkers present in patients with chronic pain. Thirteen articles that addressed the plasma biomarkers levels in humans with chronic pain were selected. Most of the articles presented the cytokines levels, followed by cortisol. Only one article mentioned the nitric oxide, and none mentioned what plasma levels of extracellular matrix metalloproteinases and bradykinins were identified. CONCLUSION: Changes were observed in inflammatory and anti-inflammatory cytokine plasma levels, and that cortisol is related to anxiety and depression symptoms in patients with chronic pain. However, it was not possible to identify the changes in plasma levels of nitric oxide, bradykinin, and extracellular matrix metalloproteinases due to the absence of scientific evidence. |
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Systemic alterations in plasma biomarkers levels in patients with chronic painBiomarkersChronic painPlasmaABSTRACT BACKGROUND AND OBJECTIVES: To analyze the scientific evidence on the changes in plasma levels of interleukins, nitric oxide, extracellular matrix metalloproteinases, bradykinins, and cortisol in patients with chronic pain. CONTENTS: The studies were identified by searching the following electronic databases: Pubmed/Medline, Scopus, LILACS, and Web of Science, published from June of 2016 to December of 2016. The selected articles were presented in a flow chart based on their identification, selection, eligibility and inclusion and exclusion criteria. The content of the articles included in the study was analyzed to identify the biomarkers present in patients with chronic pain. Thirteen articles that addressed the plasma biomarkers levels in humans with chronic pain were selected. Most of the articles presented the cytokines levels, followed by cortisol. Only one article mentioned the nitric oxide, and none mentioned what plasma levels of extracellular matrix metalloproteinases and bradykinins were identified. CONCLUSION: Changes were observed in inflammatory and anti-inflammatory cytokine plasma levels, and that cortisol is related to anxiety and depression symptoms in patients with chronic pain. However, it was not possible to identify the changes in plasma levels of nitric oxide, bradykinin, and extracellular matrix metalloproteinases due to the absence of scientific evidence.Sociedade Brasileira para o Estudo da Dor2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922019000300274BrJP v.2 n.3 2019reponame:BrJP (Online)instname:Sociedade Brasileira para o Estudo da Dor (SBED)instacron:SBED10.5935/2595-0118.20190048info:eu-repo/semantics/openAccessVendrusculo-Fangel,Leticia MedaFangel,RenanMarqueti,Rita de Cássiaeng2019-09-18T00:00:00Zoai:scielo:S2595-31922019000300274Revistahttps://sbed.org.br/publicacoes-publicacoes-bjp/ONGhttps://old.scielo.br/oai/scielo-oai.phpdkt@terra.com.br || dor@dor.org.br2595-31922595-0118opendoar:2019-09-18T00:00BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED)false |
dc.title.none.fl_str_mv |
Systemic alterations in plasma biomarkers levels in patients with chronic pain |
title |
Systemic alterations in plasma biomarkers levels in patients with chronic pain |
spellingShingle |
Systemic alterations in plasma biomarkers levels in patients with chronic pain Vendrusculo-Fangel,Leticia Meda Biomarkers Chronic pain Plasma |
title_short |
Systemic alterations in plasma biomarkers levels in patients with chronic pain |
title_full |
Systemic alterations in plasma biomarkers levels in patients with chronic pain |
title_fullStr |
Systemic alterations in plasma biomarkers levels in patients with chronic pain |
title_full_unstemmed |
Systemic alterations in plasma biomarkers levels in patients with chronic pain |
title_sort |
Systemic alterations in plasma biomarkers levels in patients with chronic pain |
author |
Vendrusculo-Fangel,Leticia Meda |
author_facet |
Vendrusculo-Fangel,Leticia Meda Fangel,Renan Marqueti,Rita de Cássia |
author_role |
author |
author2 |
Fangel,Renan Marqueti,Rita de Cássia |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Vendrusculo-Fangel,Leticia Meda Fangel,Renan Marqueti,Rita de Cássia |
dc.subject.por.fl_str_mv |
Biomarkers Chronic pain Plasma |
topic |
Biomarkers Chronic pain Plasma |
description |
ABSTRACT BACKGROUND AND OBJECTIVES: To analyze the scientific evidence on the changes in plasma levels of interleukins, nitric oxide, extracellular matrix metalloproteinases, bradykinins, and cortisol in patients with chronic pain. CONTENTS: The studies were identified by searching the following electronic databases: Pubmed/Medline, Scopus, LILACS, and Web of Science, published from June of 2016 to December of 2016. The selected articles were presented in a flow chart based on their identification, selection, eligibility and inclusion and exclusion criteria. The content of the articles included in the study was analyzed to identify the biomarkers present in patients with chronic pain. Thirteen articles that addressed the plasma biomarkers levels in humans with chronic pain were selected. Most of the articles presented the cytokines levels, followed by cortisol. Only one article mentioned the nitric oxide, and none mentioned what plasma levels of extracellular matrix metalloproteinases and bradykinins were identified. CONCLUSION: Changes were observed in inflammatory and anti-inflammatory cytokine plasma levels, and that cortisol is related to anxiety and depression symptoms in patients with chronic pain. However, it was not possible to identify the changes in plasma levels of nitric oxide, bradykinin, and extracellular matrix metalloproteinases due to the absence of scientific evidence. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922019000300274 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922019000300274 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/2595-0118.20190048 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Estudo da Dor |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Estudo da Dor |
dc.source.none.fl_str_mv |
BrJP v.2 n.3 2019 reponame:BrJP (Online) instname:Sociedade Brasileira para o Estudo da Dor (SBED) instacron:SBED |
instname_str |
Sociedade Brasileira para o Estudo da Dor (SBED) |
instacron_str |
SBED |
institution |
SBED |
reponame_str |
BrJP (Online) |
collection |
BrJP (Online) |
repository.name.fl_str_mv |
BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED) |
repository.mail.fl_str_mv |
dkt@terra.com.br || dor@dor.org.br |
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1754732509865705472 |