Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model

Detalhes bibliográficos
Autor(a) principal: Neves,Morgana
Data de Publicação: 2020
Outros Autores: Tavares,Alana Ludemila de Freitas, Retameiro,Ana Caroline Barbosa, Leal,Taciane Stein da Silva, Ribeiro,Lucinéia de Fátima Chasko, Bertolini,Gladson Ricardo Flor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: BrJP (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922020000100008
Resumo: ABSTRACT BACKGROUND AND OBJECTIVES: The deleterious effects of rheumatoid arthritis on periarticular tissues have not yet been fully elucidated. Therefore, the search for treatments that can modulate the inflammatory profile and tissue remodeling is pertinent. The present study evaluated the effects of low-level laser therapy (LLLT) on the morphology of periarticular tissues and synovial membrane of rats in a rheumatoid arthritis model. METHODS: Sixty-four male rats were divided into acute (7 days) and chronic (28 days) inflammatory periods, with four groups (n=8) each, being: CG (control group), LG (lesion group), CLaG (laser control group) and LLaG (laser lesion group). The animals of the lesion groups received two inoculations of Freund’s Complete Adjuvant at a concentration of 50µL, the first at the base of the tail, and the second at the right knee. The animals in the control groups were injected with isotonic sodium chloride solution. The ClaG and LLaG were treated with 660nm LBI, 5J/cm2 in the right knee. After the experimental period, the animals were euthanized, and the knees were processed for light microscopy. RESULTS: The CG and CLaG morphological analysis had normal aspects. The LG showed synovitis, femur, and tibia with changes in the periosteum, with inflammatory cells and bone modifications. In the LLaG, the synovial membrane showed signs of improvement. Bone tissue in the chronic period showed morphological aspects, denoting tissue remodeling. CONCLUSION: The experimental model was efficient in simulating inflammatory tissue events, and the low-level laser therapy showed beneficial effects on the morphology of the periarticular tissues.
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spelling Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis modelKnee jointLaser therapyRheumatoid arthritisABSTRACT BACKGROUND AND OBJECTIVES: The deleterious effects of rheumatoid arthritis on periarticular tissues have not yet been fully elucidated. Therefore, the search for treatments that can modulate the inflammatory profile and tissue remodeling is pertinent. The present study evaluated the effects of low-level laser therapy (LLLT) on the morphology of periarticular tissues and synovial membrane of rats in a rheumatoid arthritis model. METHODS: Sixty-four male rats were divided into acute (7 days) and chronic (28 days) inflammatory periods, with four groups (n=8) each, being: CG (control group), LG (lesion group), CLaG (laser control group) and LLaG (laser lesion group). The animals of the lesion groups received two inoculations of Freund’s Complete Adjuvant at a concentration of 50µL, the first at the base of the tail, and the second at the right knee. The animals in the control groups were injected with isotonic sodium chloride solution. The ClaG and LLaG were treated with 660nm LBI, 5J/cm2 in the right knee. After the experimental period, the animals were euthanized, and the knees were processed for light microscopy. RESULTS: The CG and CLaG morphological analysis had normal aspects. The LG showed synovitis, femur, and tibia with changes in the periosteum, with inflammatory cells and bone modifications. In the LLaG, the synovial membrane showed signs of improvement. Bone tissue in the chronic period showed morphological aspects, denoting tissue remodeling. CONCLUSION: The experimental model was efficient in simulating inflammatory tissue events, and the low-level laser therapy showed beneficial effects on the morphology of the periarticular tissues.Sociedade Brasileira para o Estudo da Dor2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922020000100008BrJP v.3 n.1 2020reponame:BrJP (Online)instname:Sociedade Brasileira para o Estudo da Dor (SBED)instacron:SBED10.5935/2595-0118.20200003info:eu-repo/semantics/openAccessNeves,MorganaTavares,Alana Ludemila de FreitasRetameiro,Ana Caroline BarbosaLeal,Taciane Stein da SilvaRibeiro,Lucinéia de Fátima ChaskoBertolini,Gladson Ricardo Floreng2020-02-19T00:00:00Zoai:scielo:S2595-31922020000100008Revistahttps://sbed.org.br/publicacoes-publicacoes-bjp/ONGhttps://old.scielo.br/oai/scielo-oai.phpdkt@terra.com.br || dor@dor.org.br2595-31922595-0118opendoar:2020-02-19T00:00BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED)false
dc.title.none.fl_str_mv Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
title Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
spellingShingle Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
Neves,Morgana
Knee joint
Laser therapy
Rheumatoid arthritis
title_short Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
title_full Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
title_fullStr Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
title_full_unstemmed Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
title_sort Low-level laser therapy in periarticular morphological aspects of the knee of Wistar rats in rheumatoid arthritis model
author Neves,Morgana
author_facet Neves,Morgana
Tavares,Alana Ludemila de Freitas
Retameiro,Ana Caroline Barbosa
Leal,Taciane Stein da Silva
Ribeiro,Lucinéia de Fátima Chasko
Bertolini,Gladson Ricardo Flor
author_role author
author2 Tavares,Alana Ludemila de Freitas
Retameiro,Ana Caroline Barbosa
Leal,Taciane Stein da Silva
Ribeiro,Lucinéia de Fátima Chasko
Bertolini,Gladson Ricardo Flor
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Neves,Morgana
Tavares,Alana Ludemila de Freitas
Retameiro,Ana Caroline Barbosa
Leal,Taciane Stein da Silva
Ribeiro,Lucinéia de Fátima Chasko
Bertolini,Gladson Ricardo Flor
dc.subject.por.fl_str_mv Knee joint
Laser therapy
Rheumatoid arthritis
topic Knee joint
Laser therapy
Rheumatoid arthritis
description ABSTRACT BACKGROUND AND OBJECTIVES: The deleterious effects of rheumatoid arthritis on periarticular tissues have not yet been fully elucidated. Therefore, the search for treatments that can modulate the inflammatory profile and tissue remodeling is pertinent. The present study evaluated the effects of low-level laser therapy (LLLT) on the morphology of periarticular tissues and synovial membrane of rats in a rheumatoid arthritis model. METHODS: Sixty-four male rats were divided into acute (7 days) and chronic (28 days) inflammatory periods, with four groups (n=8) each, being: CG (control group), LG (lesion group), CLaG (laser control group) and LLaG (laser lesion group). The animals of the lesion groups received two inoculations of Freund’s Complete Adjuvant at a concentration of 50µL, the first at the base of the tail, and the second at the right knee. The animals in the control groups were injected with isotonic sodium chloride solution. The ClaG and LLaG were treated with 660nm LBI, 5J/cm2 in the right knee. After the experimental period, the animals were euthanized, and the knees were processed for light microscopy. RESULTS: The CG and CLaG morphological analysis had normal aspects. The LG showed synovitis, femur, and tibia with changes in the periosteum, with inflammatory cells and bone modifications. In the LLaG, the synovial membrane showed signs of improvement. Bone tissue in the chronic period showed morphological aspects, denoting tissue remodeling. CONCLUSION: The experimental model was efficient in simulating inflammatory tissue events, and the low-level laser therapy showed beneficial effects on the morphology of the periarticular tissues.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922020000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922020000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/2595-0118.20200003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Estudo da Dor
publisher.none.fl_str_mv Sociedade Brasileira para o Estudo da Dor
dc.source.none.fl_str_mv BrJP v.3 n.1 2020
reponame:BrJP (Online)
instname:Sociedade Brasileira para o Estudo da Dor (SBED)
instacron:SBED
instname_str Sociedade Brasileira para o Estudo da Dor (SBED)
instacron_str SBED
institution SBED
reponame_str BrJP (Online)
collection BrJP (Online)
repository.name.fl_str_mv BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED)
repository.mail.fl_str_mv dkt@terra.com.br || dor@dor.org.br
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