Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | BrJP (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922021000200099 |
Resumo: | ABSTRACT BACKGROUND AND OBJECTIVES: The expression of nerve growth factor (NGF) in the large-size neurons may represent a key role in the neuronal synaptic plasticity and re-organization of neuronal function after a nerve injury. Transcranial direct current stimulation (tDCS) is a non-invasive method of cerebral stimulation and represents a promising tool to pain management since it promotes neuroplasticity in the central system, and it can be combined with other interventions. The aim was to investigate the effects of tDCS in the NGF levels in central and peripheral nervous system structures of rats submitted to a neuropathic pain (NP) model. METHODS: The chronic constriction injury (CCI) of sciatic nerve was used for the induction of NP. For sham surgery, the sciatic nerve was exposed, but without any ligation. The control group did not undergo surgical procedure. After the establishment of NP, treated groups were subjected to tDCS treatment 0.5 mA/20min/day/8 days. NGF levels in cerebral cortex, spinal cord and sciatic nerve were determined by sandwich-ELISA at 48 hours and 7 days after the end of treatment. RESULTS: The CCI model increased NGF levels in all three structures analyzed at long-lasting time, evidencing the importance of this neurotrophin in neuropathic pain condition. On the other hand, there was no tDCS effect in the central and peripheral NGF levels discarding the participation of this neurotrophin in the analgesic tDCS effect. CONCLUSION: tDCS modulation effects of nociceptive pathways seem not to be linked to the NGF signaling in this chronic pain model. |
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Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in ratsNerve growth factorPainRatsTranscranial direct current stimulationABSTRACT BACKGROUND AND OBJECTIVES: The expression of nerve growth factor (NGF) in the large-size neurons may represent a key role in the neuronal synaptic plasticity and re-organization of neuronal function after a nerve injury. Transcranial direct current stimulation (tDCS) is a non-invasive method of cerebral stimulation and represents a promising tool to pain management since it promotes neuroplasticity in the central system, and it can be combined with other interventions. The aim was to investigate the effects of tDCS in the NGF levels in central and peripheral nervous system structures of rats submitted to a neuropathic pain (NP) model. METHODS: The chronic constriction injury (CCI) of sciatic nerve was used for the induction of NP. For sham surgery, the sciatic nerve was exposed, but without any ligation. The control group did not undergo surgical procedure. After the establishment of NP, treated groups were subjected to tDCS treatment 0.5 mA/20min/day/8 days. NGF levels in cerebral cortex, spinal cord and sciatic nerve were determined by sandwich-ELISA at 48 hours and 7 days after the end of treatment. RESULTS: The CCI model increased NGF levels in all three structures analyzed at long-lasting time, evidencing the importance of this neurotrophin in neuropathic pain condition. On the other hand, there was no tDCS effect in the central and peripheral NGF levels discarding the participation of this neurotrophin in the analgesic tDCS effect. CONCLUSION: tDCS modulation effects of nociceptive pathways seem not to be linked to the NGF signaling in this chronic pain model.Sociedade Brasileira para o Estudo da Dor2021-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922021000200099BrJP v.4 n.2 2021reponame:BrJP (Online)instname:Sociedade Brasileira para o Estudo da Dor (SBED)instacron:SBED10.5935/2595-0118.20210031info:eu-repo/semantics/openAccessCioato,Stefania GiottiMedeiros,Liciane FernandesLopes,Bettega CostaSouza,Andressa deCaumo,WolneiTorres,Iraci Lucena da Silvaeng2021-07-21T00:00:00Zoai:scielo:S2595-31922021000200099Revistahttps://sbed.org.br/publicacoes-publicacoes-bjp/ONGhttps://old.scielo.br/oai/scielo-oai.phpdkt@terra.com.br || dor@dor.org.br2595-31922595-0118opendoar:2021-07-21T00:00BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED)false |
dc.title.none.fl_str_mv |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats |
title |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats |
spellingShingle |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats Cioato,Stefania Giotti Nerve growth factor Pain Rats Transcranial direct current stimulation |
title_short |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats |
title_full |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats |
title_fullStr |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats |
title_full_unstemmed |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats |
title_sort |
Transcranial direct current stimulation did not revert the increased central and peripheral NGF levels induced by neuropathic pain in rats |
author |
Cioato,Stefania Giotti |
author_facet |
Cioato,Stefania Giotti Medeiros,Liciane Fernandes Lopes,Bettega Costa Souza,Andressa de Caumo,Wolnei Torres,Iraci Lucena da Silva |
author_role |
author |
author2 |
Medeiros,Liciane Fernandes Lopes,Bettega Costa Souza,Andressa de Caumo,Wolnei Torres,Iraci Lucena da Silva |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cioato,Stefania Giotti Medeiros,Liciane Fernandes Lopes,Bettega Costa Souza,Andressa de Caumo,Wolnei Torres,Iraci Lucena da Silva |
dc.subject.por.fl_str_mv |
Nerve growth factor Pain Rats Transcranial direct current stimulation |
topic |
Nerve growth factor Pain Rats Transcranial direct current stimulation |
description |
ABSTRACT BACKGROUND AND OBJECTIVES: The expression of nerve growth factor (NGF) in the large-size neurons may represent a key role in the neuronal synaptic plasticity and re-organization of neuronal function after a nerve injury. Transcranial direct current stimulation (tDCS) is a non-invasive method of cerebral stimulation and represents a promising tool to pain management since it promotes neuroplasticity in the central system, and it can be combined with other interventions. The aim was to investigate the effects of tDCS in the NGF levels in central and peripheral nervous system structures of rats submitted to a neuropathic pain (NP) model. METHODS: The chronic constriction injury (CCI) of sciatic nerve was used for the induction of NP. For sham surgery, the sciatic nerve was exposed, but without any ligation. The control group did not undergo surgical procedure. After the establishment of NP, treated groups were subjected to tDCS treatment 0.5 mA/20min/day/8 days. NGF levels in cerebral cortex, spinal cord and sciatic nerve were determined by sandwich-ELISA at 48 hours and 7 days after the end of treatment. RESULTS: The CCI model increased NGF levels in all three structures analyzed at long-lasting time, evidencing the importance of this neurotrophin in neuropathic pain condition. On the other hand, there was no tDCS effect in the central and peripheral NGF levels discarding the participation of this neurotrophin in the analgesic tDCS effect. CONCLUSION: tDCS modulation effects of nociceptive pathways seem not to be linked to the NGF signaling in this chronic pain model. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922021000200099 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922021000200099 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/2595-0118.20210031 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Estudo da Dor |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Estudo da Dor |
dc.source.none.fl_str_mv |
BrJP v.4 n.2 2021 reponame:BrJP (Online) instname:Sociedade Brasileira para o Estudo da Dor (SBED) instacron:SBED |
instname_str |
Sociedade Brasileira para o Estudo da Dor (SBED) |
instacron_str |
SBED |
institution |
SBED |
reponame_str |
BrJP (Online) |
collection |
BrJP (Online) |
repository.name.fl_str_mv |
BrJP (Online) - Sociedade Brasileira para o Estudo da Dor (SBED) |
repository.mail.fl_str_mv |
dkt@terra.com.br || dor@dor.org.br |
_version_ |
1754732510393139200 |