Migraine and sleep deprivation: integrative review

• Autor(a) principal: Thomaz,Tania Gouvêa
• Data de Publicação: 2021
• Outros Autores: Paula,Ana Ester Amorim de, Alves,Daniel de Moraes, Alves,Luana Lemos, Fonseca,Pedro Guilherme Mol da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: BrJP (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922021000400379
• topic: Headache; Migraine disorders; Sleep deprivation

ABSTRACT BACKGROUND AND OBJECTIVES: Migraine is a type of primary headache, and its pathophysiology remains incomplete. The relationship between sleep and migraine is easily identified by migraine patients. The aim of this review was to investigate the relationship between sleep deprivation and migraine. CONTENTS: A search was made for articles using the terms: “migraine” and “sleep deprivation” in the Pubmed, Biblioteca Virtual da Saúde (Virtual Health Library - LILACS and IBECS) and Scielo databases. The first analysis was based on title and abstract. In cases where the title and abstract were not clear, the article was accessed in its entirety. After applying the exclusion criteria, 49 articles remained. These articles were analyzed and organized into two tables: one for articles that treated sleep as a trigger and the other for articles that explored the pathophysiological relationship between sleep and migraine. CONCLUSION: It is possible that sleep deprivation causes or worsens migraine crisis due to its ability to cause oxidative stress in the brain. This in turn activates TRPA1 receptors located on first-order trigeminal neurons. Activation of these receptors initiates the sensitization process of the trigeminal system that culminates with the antidromic release of calcitonin gene-related peptide in the dural afferents of these neurons in the trigeminal ganglion. The relationship between insomnia and migraine seems to converge with this same pathophysiological process, since sleep deprivation imposed by insomnia would be able to generate a migraine crisis through increased oxidative stress.