Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Detalhes bibliográficos
Autor(a) principal: Lopes,Maicon Piana
Data de Publicação: 2016
Outros Autores: Kliemann,Breno S., Bini,Ileana Borsato, Kulchetscki,Rodrigo, Borsani,Victor, Savi,Larissa, Borba,Victoria Z. C., Moreira,Carolina A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000600532
Resumo: ABSTRACT Objectives To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities. Materials and methods Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG). Results Fifty-five patients were identified, 42 females and 13 males; mean age of 44.5 and average time of the disease of 11.2 years. The most frequent etiology was post-surgical. Levels of serum calcium and creatinine increased between the first and last visits (p < 0.001 and p < 0.05, respectively); and serum levels of phosphate decreased during the same period (p < 0.001). Out of the 55 patients, 40 had USG, and 10 (25%) presented with kidney calcifications. There was no significant difference in the amount of calcium and vitamin D doses among patients with kidney calcifications and others. No correlation between serum and urinary levels of calcium and the presence of calcification was found. Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05). Conclusions The reduction of hypocalcemia and hyperphosphatemia suggest an effectiveness of the treatment, and the increase in serum creatinine demonstrates an impairment of renal function during follow-up. Kidney calcifications were prevalent in this cohort, and higher urinary calcium excretion, even if still within the normal range, was associated with development of calcification. These findings suggest that lower rates of urinary calcium excretion should be aimed for in the management of hypoparathyroidism.
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spelling Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complicationsHypoparathyroidismrenal complicationrenal calcificationhypocalcemiapseudohypoparathyroidismABSTRACT Objectives To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities. Materials and methods Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG). Results Fifty-five patients were identified, 42 females and 13 males; mean age of 44.5 and average time of the disease of 11.2 years. The most frequent etiology was post-surgical. Levels of serum calcium and creatinine increased between the first and last visits (p < 0.001 and p < 0.05, respectively); and serum levels of phosphate decreased during the same period (p < 0.001). Out of the 55 patients, 40 had USG, and 10 (25%) presented with kidney calcifications. There was no significant difference in the amount of calcium and vitamin D doses among patients with kidney calcifications and others. No correlation between serum and urinary levels of calcium and the presence of calcification was found. Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05). Conclusions The reduction of hypocalcemia and hyperphosphatemia suggest an effectiveness of the treatment, and the increase in serum creatinine demonstrates an impairment of renal function during follow-up. Kidney calcifications were prevalent in this cohort, and higher urinary calcium excretion, even if still within the normal range, was associated with development of calcification. These findings suggest that lower rates of urinary calcium excretion should be aimed for in the management of hypoparathyroidism.Sociedade Brasileira de Endocrinologia e Metabologia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000600532Archives of Endocrinology and Metabolism v.60 n.6 2016reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/2359-3997000000221info:eu-repo/semantics/openAccessLopes,Maicon PianaKliemann,Breno S.Bini,Ileana BorsatoKulchetscki,RodrigoBorsani,VictorSavi,LarissaBorba,Victoria Z. C.Moreira,Carolina A.eng2016-12-08T00:00:00Zoai:scielo:S2359-39972016000600532Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2016-12-08T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
title Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
spellingShingle Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
Lopes,Maicon Piana
Hypoparathyroidism
renal complication
renal calcification
hypocalcemia
pseudohypoparathyroidism
title_short Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
title_full Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
title_fullStr Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
title_full_unstemmed Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
title_sort Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications
author Lopes,Maicon Piana
author_facet Lopes,Maicon Piana
Kliemann,Breno S.
Bini,Ileana Borsato
Kulchetscki,Rodrigo
Borsani,Victor
Savi,Larissa
Borba,Victoria Z. C.
Moreira,Carolina A.
author_role author
author2 Kliemann,Breno S.
Bini,Ileana Borsato
Kulchetscki,Rodrigo
Borsani,Victor
Savi,Larissa
Borba,Victoria Z. C.
Moreira,Carolina A.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes,Maicon Piana
Kliemann,Breno S.
Bini,Ileana Borsato
Kulchetscki,Rodrigo
Borsani,Victor
Savi,Larissa
Borba,Victoria Z. C.
Moreira,Carolina A.
dc.subject.por.fl_str_mv Hypoparathyroidism
renal complication
renal calcification
hypocalcemia
pseudohypoparathyroidism
topic Hypoparathyroidism
renal complication
renal calcification
hypocalcemia
pseudohypoparathyroidism
description ABSTRACT Objectives To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities. Materials and methods Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG). Results Fifty-five patients were identified, 42 females and 13 males; mean age of 44.5 and average time of the disease of 11.2 years. The most frequent etiology was post-surgical. Levels of serum calcium and creatinine increased between the first and last visits (p < 0.001 and p < 0.05, respectively); and serum levels of phosphate decreased during the same period (p < 0.001). Out of the 55 patients, 40 had USG, and 10 (25%) presented with kidney calcifications. There was no significant difference in the amount of calcium and vitamin D doses among patients with kidney calcifications and others. No correlation between serum and urinary levels of calcium and the presence of calcification was found. Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05). Conclusions The reduction of hypocalcemia and hyperphosphatemia suggest an effectiveness of the treatment, and the increase in serum creatinine demonstrates an impairment of renal function during follow-up. Kidney calcifications were prevalent in this cohort, and higher urinary calcium excretion, even if still within the normal range, was associated with development of calcification. These findings suggest that lower rates of urinary calcium excretion should be aimed for in the management of hypoparathyroidism.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/2359-3997000000221
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.60 n.6 2016
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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