COVID-19 and obesity: the meeting of two pandemics

Detalhes bibliográficos
Autor(a) principal: Brandão,Simone Cristina Soares
Data de Publicação: 2021
Outros Autores: Godoi,Emmanuelle Tenório Albuquerque Madruga, Cordeiro,Lúcia Helena de Oliveira, Bezerra,Camila Silva, Ramos,Júlia de Oliveira Xavier, Arruda,Gustavo Freitas Alves de, Lins,Esdras Marques
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000100003
Resumo: ABSTRACT COVID-19 and obesity are two pandemic diseases that the world is currently facing. Both activate the immune system and mediate inflammation. A sequence of disease phases in patients with severe COVID-19 results in a cytokine storm, which amplifies the subclinical inflammation that already exists in patients with obesity. Pro-inflammatory cytokines and chemotactic factors increase insulin resistance in obesity. Therefore, a greater systemic inflammatory response is establishe, along with an increased risk of thrombotic phenomena and hyperglycemic conditions. These changes further impair pulmonary, cardiac, hepatic, and renal functions, in addition to hindering glycemic control in people with diabetes and pre-diabetes. This review explains the pathophysiological mechanisms of these two pandemic diseases, provides a deeper understanding of this harmful interaction and lists possible therapeutic strategies for this risk group.
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spelling COVID-19 and obesity: the meeting of two pandemicsCOVID-19obesitypandemicsinsulin resistanceinflammationABSTRACT COVID-19 and obesity are two pandemic diseases that the world is currently facing. Both activate the immune system and mediate inflammation. A sequence of disease phases in patients with severe COVID-19 results in a cytokine storm, which amplifies the subclinical inflammation that already exists in patients with obesity. Pro-inflammatory cytokines and chemotactic factors increase insulin resistance in obesity. Therefore, a greater systemic inflammatory response is establishe, along with an increased risk of thrombotic phenomena and hyperglycemic conditions. These changes further impair pulmonary, cardiac, hepatic, and renal functions, in addition to hindering glycemic control in people with diabetes and pre-diabetes. This review explains the pathophysiological mechanisms of these two pandemic diseases, provides a deeper understanding of this harmful interaction and lists possible therapeutic strategies for this risk group.Sociedade Brasileira de Endocrinologia e Metabologia2021-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000100003Archives of Endocrinology and Metabolism v.65 n.1 2021reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000318info:eu-repo/semantics/openAccessBrandão,Simone Cristina SoaresGodoi,Emmanuelle Tenório Albuquerque MadrugaCordeiro,Lúcia Helena de OliveiraBezerra,Camila SilvaRamos,Júlia de Oliveira XavierArruda,Gustavo Freitas Alves deLins,Esdras Marqueseng2021-02-25T00:00:00Zoai:scielo:S2359-39972021000100003Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2021-02-25T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv COVID-19 and obesity: the meeting of two pandemics
title COVID-19 and obesity: the meeting of two pandemics
spellingShingle COVID-19 and obesity: the meeting of two pandemics
Brandão,Simone Cristina Soares
COVID-19
obesity
pandemics
insulin resistance
inflammation
title_short COVID-19 and obesity: the meeting of two pandemics
title_full COVID-19 and obesity: the meeting of two pandemics
title_fullStr COVID-19 and obesity: the meeting of two pandemics
title_full_unstemmed COVID-19 and obesity: the meeting of two pandemics
title_sort COVID-19 and obesity: the meeting of two pandemics
author Brandão,Simone Cristina Soares
author_facet Brandão,Simone Cristina Soares
Godoi,Emmanuelle Tenório Albuquerque Madruga
Cordeiro,Lúcia Helena de Oliveira
Bezerra,Camila Silva
Ramos,Júlia de Oliveira Xavier
Arruda,Gustavo Freitas Alves de
Lins,Esdras Marques
author_role author
author2 Godoi,Emmanuelle Tenório Albuquerque Madruga
Cordeiro,Lúcia Helena de Oliveira
Bezerra,Camila Silva
Ramos,Júlia de Oliveira Xavier
Arruda,Gustavo Freitas Alves de
Lins,Esdras Marques
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brandão,Simone Cristina Soares
Godoi,Emmanuelle Tenório Albuquerque Madruga
Cordeiro,Lúcia Helena de Oliveira
Bezerra,Camila Silva
Ramos,Júlia de Oliveira Xavier
Arruda,Gustavo Freitas Alves de
Lins,Esdras Marques
dc.subject.por.fl_str_mv COVID-19
obesity
pandemics
insulin resistance
inflammation
topic COVID-19
obesity
pandemics
insulin resistance
inflammation
description ABSTRACT COVID-19 and obesity are two pandemic diseases that the world is currently facing. Both activate the immune system and mediate inflammation. A sequence of disease phases in patients with severe COVID-19 results in a cytokine storm, which amplifies the subclinical inflammation that already exists in patients with obesity. Pro-inflammatory cytokines and chemotactic factors increase insulin resistance in obesity. Therefore, a greater systemic inflammatory response is establishe, along with an increased risk of thrombotic phenomena and hyperglycemic conditions. These changes further impair pulmonary, cardiac, hepatic, and renal functions, in addition to hindering glycemic control in people with diabetes and pre-diabetes. This review explains the pathophysiological mechanisms of these two pandemic diseases, provides a deeper understanding of this harmful interaction and lists possible therapeutic strategies for this risk group.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.20945/2359-3997000000318
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.65 n.1 2021
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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