Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism

• Autor(a) principal: Garmes,Heraldo Mendes
• Data de Publicação: 2021
• Outros Autores: Boguszewski,César Luiz, Miranda,Paulo Augusto Carvalho, Martins,Manoel Ricardo Alves, Silva,Silvia Regina Correa da, Abucham Filho,Julio Zaki, Musolino,Nina Rosa de Castro, Vilar,Lucio, Portari,Luiz Henrique Corrêa, Gadelha,Mônica Roberto, Kasuki,Leandro, Naves,Luciana Ansaneli, Czepielewski,Mauro Antônio, Almeida,Tobias Skrebsky de, Duarte,Felipe Henning Gaia, Glezer,Andrea, Bronstein,Marcello Delano
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000200212
• topic: Hypopituitarism; central hypothyroidism; secondary adrenal insufficiency; central hypogonadism and GH deficiency

ABSTRACT Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.