The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de Endocrinologia e Metabolismo (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600787 |
Resumo: | ABSTRACT Objective: We aimed to investigate the role of DIO2 polymorphisms rs225014 and rs12885300 in Graves’ disease patients, mainly for controlling body weight following treatment. Subjects and methods: We genotyped 280 GD patients by the time of diagnosis and 297 healthy control individuals using a TaqMan SNP Genotyping technique. We followed up 141 patients for 18.94 ± 6.59 months after treatment. Results: There was no relationship between the investigated polymorphisms with susceptibility to GD and gain or loss of weight after GD treatment. However, the polymorphic inheritance (CC+CT genotype) of DIO2 rs225014 was associated with a lower body weight variation after GD treatment (4.26 ± 6.25 kg) when compared to wild type TT genotype (6.34 ± 7.26 kg; p = 0.0456 adjusted for the follow-up time). This data was confirmed by a multivariate analysis (p = 0.0138) along with a longer follow-up period (p = 0.0228), older age (p = 0.0306), treatment with radioiodine (p-value = 0.0080) and polymorphic inheritance of DIO2 rs12885300 (p = 0.0306). Conclusion: We suggest that DIO2 rs225014 genotyping may have an auxiliary role in predicting the post-treatment weight behavior of GD patients. |
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The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatmentGraves’ DiseaseDIO2 genepolymorphismsABSTRACT Objective: We aimed to investigate the role of DIO2 polymorphisms rs225014 and rs12885300 in Graves’ disease patients, mainly for controlling body weight following treatment. Subjects and methods: We genotyped 280 GD patients by the time of diagnosis and 297 healthy control individuals using a TaqMan SNP Genotyping technique. We followed up 141 patients for 18.94 ± 6.59 months after treatment. Results: There was no relationship between the investigated polymorphisms with susceptibility to GD and gain or loss of weight after GD treatment. However, the polymorphic inheritance (CC+CT genotype) of DIO2 rs225014 was associated with a lower body weight variation after GD treatment (4.26 ± 6.25 kg) when compared to wild type TT genotype (6.34 ± 7.26 kg; p = 0.0456 adjusted for the follow-up time). This data was confirmed by a multivariate analysis (p = 0.0138) along with a longer follow-up period (p = 0.0228), older age (p = 0.0306), treatment with radioiodine (p-value = 0.0080) and polymorphic inheritance of DIO2 rs12885300 (p = 0.0306). Conclusion: We suggest that DIO2 rs225014 genotyping may have an auxiliary role in predicting the post-treatment weight behavior of GD patients.Sociedade Brasileira de Endocrinologia e Metabologia2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600787Archives of Endocrinology and Metabolism v.64 n.6 2020reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000295info:eu-repo/semantics/openAccessComarella,Ana PaulaVilagellin,DaniloBufalo,Natassia ElenaEuflauzino,Jessica FerreiraTeixeira,Elisangela de SouzaMiklos,Ana Beatriz Pinotti PedroSantos,Roberto Bernardo dosRomaldini,João H.Ward,Laura S.eng2021-02-25T00:00:00Zoai:scielo:S2359-39972020000600787Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2021-02-25T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment |
title |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment |
spellingShingle |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment Comarella,Ana Paula Graves’ Disease DIO2 gene polymorphisms |
title_short |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment |
title_full |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment |
title_fullStr |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment |
title_full_unstemmed |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment |
title_sort |
The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment |
author |
Comarella,Ana Paula |
author_facet |
Comarella,Ana Paula Vilagellin,Danilo Bufalo,Natassia Elena Euflauzino,Jessica Ferreira Teixeira,Elisangela de Souza Miklos,Ana Beatriz Pinotti Pedro Santos,Roberto Bernardo dos Romaldini,João H. Ward,Laura S. |
author_role |
author |
author2 |
Vilagellin,Danilo Bufalo,Natassia Elena Euflauzino,Jessica Ferreira Teixeira,Elisangela de Souza Miklos,Ana Beatriz Pinotti Pedro Santos,Roberto Bernardo dos Romaldini,João H. Ward,Laura S. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Comarella,Ana Paula Vilagellin,Danilo Bufalo,Natassia Elena Euflauzino,Jessica Ferreira Teixeira,Elisangela de Souza Miklos,Ana Beatriz Pinotti Pedro Santos,Roberto Bernardo dos Romaldini,João H. Ward,Laura S. |
dc.subject.por.fl_str_mv |
Graves’ Disease DIO2 gene polymorphisms |
topic |
Graves’ Disease DIO2 gene polymorphisms |
description |
ABSTRACT Objective: We aimed to investigate the role of DIO2 polymorphisms rs225014 and rs12885300 in Graves’ disease patients, mainly for controlling body weight following treatment. Subjects and methods: We genotyped 280 GD patients by the time of diagnosis and 297 healthy control individuals using a TaqMan SNP Genotyping technique. We followed up 141 patients for 18.94 ± 6.59 months after treatment. Results: There was no relationship between the investigated polymorphisms with susceptibility to GD and gain or loss of weight after GD treatment. However, the polymorphic inheritance (CC+CT genotype) of DIO2 rs225014 was associated with a lower body weight variation after GD treatment (4.26 ± 6.25 kg) when compared to wild type TT genotype (6.34 ± 7.26 kg; p = 0.0456 adjusted for the follow-up time). This data was confirmed by a multivariate analysis (p = 0.0138) along with a longer follow-up period (p = 0.0228), older age (p = 0.0306), treatment with radioiodine (p-value = 0.0080) and polymorphic inheritance of DIO2 rs12885300 (p = 0.0306). Conclusion: We suggest that DIO2 rs225014 genotyping may have an auxiliary role in predicting the post-treatment weight behavior of GD patients. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600787 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600787 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.20945/2359-3997000000295 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Archives of Endocrinology and Metabolism v.64 n.6 2020 reponame:Arquivos de Endocrinologia e Metabolismo (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos de Endocrinologia e Metabolismo (Online) |
collection |
Arquivos de Endocrinologia e Metabolismo (Online) |
repository.name.fl_str_mv |
Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||aem.editorial.office@endocrino.org.br |
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1752122517429944320 |