DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic

Detalhes bibliográficos
Autor(a) principal: Luciano,Thais Milioni
Data de Publicação: 2022
Outros Autores: Halah,Mariana Peduti, Sarti,Mariana Teresa Alves, Floriano,Vitor Gonçalves, Fonseca,Benedito Antônio Lopes da, Liberatore Junior,Raphael Del Roio, Antonini,Sonir Rauber
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000100088
Resumo: ABSTRACT We assess the severity and frequency of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes mellitus (T1D) patients and in patients with previous diagnosis of T1D in a referral Brazilian university hospital in the first five months of the COVID-19 pandemic. We also compare the data with data from pre-pandemic periods. Forty-three new-onset T1D patients were diagnosed between April and August of the years 2017, 2018, 2019, and 2020. During the COVID-19 pandemic, the number of new-onset T1D was over twice the number of new-onset T1D in the same period in the three previous years. All the 43 patients survived and are now on outpatient follow-up. We also compared the characteristics of the T1D patients hospitalized between April and August of the years 2017, 2018, and 2019 (32 hospitalizations) to the characteristics of the T1D patients hospitalized between April and August/2020 (35 hospitalizations; 1 patient was hospitalized twice in this period). Fourteen of the 34 patients admitted during the pandemic presented with COVID-19-related symptoms (any respiratory symptom, fever, nausea, vomiting, and diarrhea), but only one had positive SARS-CoV-2 RT-PCR test. Samples from 32 out of these 34 patients were assayed for SARS-CoV-2 antibodies, and four patients were positive for total antibodies (IgM and IgG). In agreement with recent reports from European countries, we observed increased frequency of DKA and severe DKA in new-onset and previously diagnosed T1D children and adolescents in a large referral public hospital in Brazil in the first five months of the COVID-19 pandemic. The reasons for this outcome might have been fear of SARS-CoV-2 infection in emergency settings, the more limited availability of primary healthcare, and the lack of school personnel’s attention toward children’s general well-being.
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spelling DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemicDKAType 1 diabetesSars-CoV-19coronavirus pandemicABSTRACT We assess the severity and frequency of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes mellitus (T1D) patients and in patients with previous diagnosis of T1D in a referral Brazilian university hospital in the first five months of the COVID-19 pandemic. We also compare the data with data from pre-pandemic periods. Forty-three new-onset T1D patients were diagnosed between April and August of the years 2017, 2018, 2019, and 2020. During the COVID-19 pandemic, the number of new-onset T1D was over twice the number of new-onset T1D in the same period in the three previous years. All the 43 patients survived and are now on outpatient follow-up. We also compared the characteristics of the T1D patients hospitalized between April and August of the years 2017, 2018, and 2019 (32 hospitalizations) to the characteristics of the T1D patients hospitalized between April and August/2020 (35 hospitalizations; 1 patient was hospitalized twice in this period). Fourteen of the 34 patients admitted during the pandemic presented with COVID-19-related symptoms (any respiratory symptom, fever, nausea, vomiting, and diarrhea), but only one had positive SARS-CoV-2 RT-PCR test. Samples from 32 out of these 34 patients were assayed for SARS-CoV-2 antibodies, and four patients were positive for total antibodies (IgM and IgG). In agreement with recent reports from European countries, we observed increased frequency of DKA and severe DKA in new-onset and previously diagnosed T1D children and adolescents in a large referral public hospital in Brazil in the first five months of the COVID-19 pandemic. The reasons for this outcome might have been fear of SARS-CoV-2 infection in emergency settings, the more limited availability of primary healthcare, and the lack of school personnel’s attention toward children’s general well-being.Sociedade Brasileira de Endocrinologia e Metabologia2022-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000100088Archives of Endocrinology and Metabolism v.66 n.1 2022reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000433info:eu-repo/semantics/openAccessLuciano,Thais MilioniHalah,Mariana PedutiSarti,Mariana Teresa AlvesFloriano,Vitor GonçalvesFonseca,Benedito Antônio Lopes daLiberatore Junior,Raphael Del RoioAntonini,Sonir Raubereng2022-03-15T00:00:00Zoai:scielo:S2359-39972022000100088Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2022-03-15T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
title DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
spellingShingle DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
Luciano,Thais Milioni
DKA
Type 1 diabetes
Sars-CoV-19
coronavirus pandemic
title_short DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
title_full DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
title_fullStr DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
title_full_unstemmed DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
title_sort DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVID-19 pandemic
author Luciano,Thais Milioni
author_facet Luciano,Thais Milioni
Halah,Mariana Peduti
Sarti,Mariana Teresa Alves
Floriano,Vitor Gonçalves
Fonseca,Benedito Antônio Lopes da
Liberatore Junior,Raphael Del Roio
Antonini,Sonir Rauber
author_role author
author2 Halah,Mariana Peduti
Sarti,Mariana Teresa Alves
Floriano,Vitor Gonçalves
Fonseca,Benedito Antônio Lopes da
Liberatore Junior,Raphael Del Roio
Antonini,Sonir Rauber
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luciano,Thais Milioni
Halah,Mariana Peduti
Sarti,Mariana Teresa Alves
Floriano,Vitor Gonçalves
Fonseca,Benedito Antônio Lopes da
Liberatore Junior,Raphael Del Roio
Antonini,Sonir Rauber
dc.subject.por.fl_str_mv DKA
Type 1 diabetes
Sars-CoV-19
coronavirus pandemic
topic DKA
Type 1 diabetes
Sars-CoV-19
coronavirus pandemic
description ABSTRACT We assess the severity and frequency of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes mellitus (T1D) patients and in patients with previous diagnosis of T1D in a referral Brazilian university hospital in the first five months of the COVID-19 pandemic. We also compare the data with data from pre-pandemic periods. Forty-three new-onset T1D patients were diagnosed between April and August of the years 2017, 2018, 2019, and 2020. During the COVID-19 pandemic, the number of new-onset T1D was over twice the number of new-onset T1D in the same period in the three previous years. All the 43 patients survived and are now on outpatient follow-up. We also compared the characteristics of the T1D patients hospitalized between April and August of the years 2017, 2018, and 2019 (32 hospitalizations) to the characteristics of the T1D patients hospitalized between April and August/2020 (35 hospitalizations; 1 patient was hospitalized twice in this period). Fourteen of the 34 patients admitted during the pandemic presented with COVID-19-related symptoms (any respiratory symptom, fever, nausea, vomiting, and diarrhea), but only one had positive SARS-CoV-2 RT-PCR test. Samples from 32 out of these 34 patients were assayed for SARS-CoV-2 antibodies, and four patients were positive for total antibodies (IgM and IgG). In agreement with recent reports from European countries, we observed increased frequency of DKA and severe DKA in new-onset and previously diagnosed T1D children and adolescents in a large referral public hospital in Brazil in the first five months of the COVID-19 pandemic. The reasons for this outcome might have been fear of SARS-CoV-2 infection in emergency settings, the more limited availability of primary healthcare, and the lack of school personnel’s attention toward children’s general well-being.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000100088
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.20945/2359-3997000000433
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.66 n.1 2022
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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