Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?

Detalhes bibliográficos
Autor(a) principal: Maniçoba,Ana Cyntia B. N.
Data de Publicação: 2020
Outros Autores: Oliveira Neto,Clariano P., Nascimento,Johnny. R., Nascimento,Flávia R. F., Brito,Haissa O., Costa,Rui Miguel Gil da, Barbosa,Maria do Carmo L., Faria,Manuel dos Santos, Nascimento,Maria do Desterro S. B., Brito,Luciane M. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276
Resumo: ABSTRACT Objective Climacterium is associated with elevated leptin levels and increased risk of cardiovascular disorders. Conflicting data diverge on whether high leptin levels in climacterium reflect increasing adipose mass or, at least partially, age-related hormonal changes. This study addresses this issue in women from a Brazilian state with a low human development index. Subjects and methods A case-control study was conducted, enrolling 136 women from the state of Maranhão, 52 (38.2%) climacteric and 84 (61.8%) non-climacteric. Biometric, biochemical, hormonal and immunological parameters were analyzed. Results Climacteric women showed a moderately increased waist/hip ratio (0.894 versus 0.834, p < 0.05), sustained body mass index (27.46 versus 28.68, p > 0.05) increased leptin levels (9.59 versus 7.13, p < 0.05) and no evidence of metabolic syndrome. No other parameters were altered. The climacteric cohort didn’t show significant body fat gains but displayed a typical age-related redistribution of adipose tissue. Even so, leptin levels were significantly elevated compared with non-climacteric women. Conclusions Altogether, these data support the hypothesis that leptin is elevated, at least partially, as a function of age and climacterium and is not necessarily correlated with metabolic dysfunction and systemic inflammation. Further studies are needed to evaluate the impact of higher leptin levels on postmenopausal women. Arch Endocrinol Metab. 2020;64(3):276-81
id SBEM-1_aae36ed8af1c5f214ac92d6f722a5c6c
oai_identifier_str oai:scielo:S2359-39972020000300276
network_acronym_str SBEM-1
network_name_str Arquivos de Endocrinologia e Metabolismo (Online)
repository_id_str
spelling Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?Metabolic syndrome, menopauseleptinclimacteriuminflammationABSTRACT Objective Climacterium is associated with elevated leptin levels and increased risk of cardiovascular disorders. Conflicting data diverge on whether high leptin levels in climacterium reflect increasing adipose mass or, at least partially, age-related hormonal changes. This study addresses this issue in women from a Brazilian state with a low human development index. Subjects and methods A case-control study was conducted, enrolling 136 women from the state of Maranhão, 52 (38.2%) climacteric and 84 (61.8%) non-climacteric. Biometric, biochemical, hormonal and immunological parameters were analyzed. Results Climacteric women showed a moderately increased waist/hip ratio (0.894 versus 0.834, p < 0.05), sustained body mass index (27.46 versus 28.68, p > 0.05) increased leptin levels (9.59 versus 7.13, p < 0.05) and no evidence of metabolic syndrome. No other parameters were altered. The climacteric cohort didn’t show significant body fat gains but displayed a typical age-related redistribution of adipose tissue. Even so, leptin levels were significantly elevated compared with non-climacteric women. Conclusions Altogether, these data support the hypothesis that leptin is elevated, at least partially, as a function of age and climacterium and is not necessarily correlated with metabolic dysfunction and systemic inflammation. Further studies are needed to evaluate the impact of higher leptin levels on postmenopausal women. Arch Endocrinol Metab. 2020;64(3):276-81Sociedade Brasileira de Endocrinologia e Metabologia2020-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276Archives of Endocrinology and Metabolism v.64 n.3 2020reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000249info:eu-repo/semantics/openAccessManiçoba,Ana Cyntia B. N.Oliveira Neto,Clariano P.Nascimento,Johnny. R.Nascimento,Flávia R. F.Brito,Haissa O.Costa,Rui Miguel Gil daBarbosa,Maria do Carmo L.Faria,Manuel dos SantosNascimento,Maria do Desterro S. B.Brito,Luciane M. O.eng2020-06-09T00:00:00Zoai:scielo:S2359-39972020000300276Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2020-06-09T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
title Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
spellingShingle Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
Maniçoba,Ana Cyntia B. N.
Metabolic syndrome, menopause
leptin
climacterium
inflammation
title_short Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
title_full Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
title_fullStr Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
title_full_unstemmed Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
title_sort Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
author Maniçoba,Ana Cyntia B. N.
author_facet Maniçoba,Ana Cyntia B. N.
Oliveira Neto,Clariano P.
Nascimento,Johnny. R.
Nascimento,Flávia R. F.
Brito,Haissa O.
Costa,Rui Miguel Gil da
Barbosa,Maria do Carmo L.
Faria,Manuel dos Santos
Nascimento,Maria do Desterro S. B.
Brito,Luciane M. O.
author_role author
author2 Oliveira Neto,Clariano P.
Nascimento,Johnny. R.
Nascimento,Flávia R. F.
Brito,Haissa O.
Costa,Rui Miguel Gil da
Barbosa,Maria do Carmo L.
Faria,Manuel dos Santos
Nascimento,Maria do Desterro S. B.
Brito,Luciane M. O.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maniçoba,Ana Cyntia B. N.
Oliveira Neto,Clariano P.
Nascimento,Johnny. R.
Nascimento,Flávia R. F.
Brito,Haissa O.
Costa,Rui Miguel Gil da
Barbosa,Maria do Carmo L.
Faria,Manuel dos Santos
Nascimento,Maria do Desterro S. B.
Brito,Luciane M. O.
dc.subject.por.fl_str_mv Metabolic syndrome, menopause
leptin
climacterium
inflammation
topic Metabolic syndrome, menopause
leptin
climacterium
inflammation
description ABSTRACT Objective Climacterium is associated with elevated leptin levels and increased risk of cardiovascular disorders. Conflicting data diverge on whether high leptin levels in climacterium reflect increasing adipose mass or, at least partially, age-related hormonal changes. This study addresses this issue in women from a Brazilian state with a low human development index. Subjects and methods A case-control study was conducted, enrolling 136 women from the state of Maranhão, 52 (38.2%) climacteric and 84 (61.8%) non-climacteric. Biometric, biochemical, hormonal and immunological parameters were analyzed. Results Climacteric women showed a moderately increased waist/hip ratio (0.894 versus 0.834, p < 0.05), sustained body mass index (27.46 versus 28.68, p > 0.05) increased leptin levels (9.59 versus 7.13, p < 0.05) and no evidence of metabolic syndrome. No other parameters were altered. The climacteric cohort didn’t show significant body fat gains but displayed a typical age-related redistribution of adipose tissue. Even so, leptin levels were significantly elevated compared with non-climacteric women. Conclusions Altogether, these data support the hypothesis that leptin is elevated, at least partially, as a function of age and climacterium and is not necessarily correlated with metabolic dysfunction and systemic inflammation. Further studies are needed to evaluate the impact of higher leptin levels on postmenopausal women. Arch Endocrinol Metab. 2020;64(3):276-81
publishDate 2020
dc.date.none.fl_str_mv 2020-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.20945/2359-3997000000249
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.64 n.3 2020
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
_version_ 1752122516565917696