Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de Endocrinologia e Metabolismo (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276 |
Resumo: | ABSTRACT Objective Climacterium is associated with elevated leptin levels and increased risk of cardiovascular disorders. Conflicting data diverge on whether high leptin levels in climacterium reflect increasing adipose mass or, at least partially, age-related hormonal changes. This study addresses this issue in women from a Brazilian state with a low human development index. Subjects and methods A case-control study was conducted, enrolling 136 women from the state of Maranhão, 52 (38.2%) climacteric and 84 (61.8%) non-climacteric. Biometric, biochemical, hormonal and immunological parameters were analyzed. Results Climacteric women showed a moderately increased waist/hip ratio (0.894 versus 0.834, p < 0.05), sustained body mass index (27.46 versus 28.68, p > 0.05) increased leptin levels (9.59 versus 7.13, p < 0.05) and no evidence of metabolic syndrome. No other parameters were altered. The climacteric cohort didn’t show significant body fat gains but displayed a typical age-related redistribution of adipose tissue. Even so, leptin levels were significantly elevated compared with non-climacteric women. Conclusions Altogether, these data support the hypothesis that leptin is elevated, at least partially, as a function of age and climacterium and is not necessarily correlated with metabolic dysfunction and systemic inflammation. Further studies are needed to evaluate the impact of higher leptin levels on postmenopausal women. Arch Endocrinol Metab. 2020;64(3):276-81 |
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Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity?Metabolic syndrome, menopauseleptinclimacteriuminflammationABSTRACT Objective Climacterium is associated with elevated leptin levels and increased risk of cardiovascular disorders. Conflicting data diverge on whether high leptin levels in climacterium reflect increasing adipose mass or, at least partially, age-related hormonal changes. This study addresses this issue in women from a Brazilian state with a low human development index. Subjects and methods A case-control study was conducted, enrolling 136 women from the state of Maranhão, 52 (38.2%) climacteric and 84 (61.8%) non-climacteric. Biometric, biochemical, hormonal and immunological parameters were analyzed. Results Climacteric women showed a moderately increased waist/hip ratio (0.894 versus 0.834, p < 0.05), sustained body mass index (27.46 versus 28.68, p > 0.05) increased leptin levels (9.59 versus 7.13, p < 0.05) and no evidence of metabolic syndrome. No other parameters were altered. The climacteric cohort didn’t show significant body fat gains but displayed a typical age-related redistribution of adipose tissue. Even so, leptin levels were significantly elevated compared with non-climacteric women. Conclusions Altogether, these data support the hypothesis that leptin is elevated, at least partially, as a function of age and climacterium and is not necessarily correlated with metabolic dysfunction and systemic inflammation. Further studies are needed to evaluate the impact of higher leptin levels on postmenopausal women. Arch Endocrinol Metab. 2020;64(3):276-81Sociedade Brasileira de Endocrinologia e Metabologia2020-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276Archives of Endocrinology and Metabolism v.64 n.3 2020reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000249info:eu-repo/semantics/openAccessManiçoba,Ana Cyntia B. N.Oliveira Neto,Clariano P.Nascimento,Johnny. R.Nascimento,Flávia R. F.Brito,Haissa O.Costa,Rui Miguel Gil daBarbosa,Maria do Carmo L.Faria,Manuel dos SantosNascimento,Maria do Desterro S. B.Brito,Luciane M. O.eng2020-06-09T00:00:00Zoai:scielo:S2359-39972020000300276Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2020-06-09T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? |
title |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? |
spellingShingle |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? Maniçoba,Ana Cyntia B. N. Metabolic syndrome, menopause leptin climacterium inflammation |
title_short |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? |
title_full |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? |
title_fullStr |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? |
title_full_unstemmed |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? |
title_sort |
Elevated leptin levels in healthy climacteric women from Northeastern Brazil: an effect of age or adiposity? |
author |
Maniçoba,Ana Cyntia B. N. |
author_facet |
Maniçoba,Ana Cyntia B. N. Oliveira Neto,Clariano P. Nascimento,Johnny. R. Nascimento,Flávia R. F. Brito,Haissa O. Costa,Rui Miguel Gil da Barbosa,Maria do Carmo L. Faria,Manuel dos Santos Nascimento,Maria do Desterro S. B. Brito,Luciane M. O. |
author_role |
author |
author2 |
Oliveira Neto,Clariano P. Nascimento,Johnny. R. Nascimento,Flávia R. F. Brito,Haissa O. Costa,Rui Miguel Gil da Barbosa,Maria do Carmo L. Faria,Manuel dos Santos Nascimento,Maria do Desterro S. B. Brito,Luciane M. O. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maniçoba,Ana Cyntia B. N. Oliveira Neto,Clariano P. Nascimento,Johnny. R. Nascimento,Flávia R. F. Brito,Haissa O. Costa,Rui Miguel Gil da Barbosa,Maria do Carmo L. Faria,Manuel dos Santos Nascimento,Maria do Desterro S. B. Brito,Luciane M. O. |
dc.subject.por.fl_str_mv |
Metabolic syndrome, menopause leptin climacterium inflammation |
topic |
Metabolic syndrome, menopause leptin climacterium inflammation |
description |
ABSTRACT Objective Climacterium is associated with elevated leptin levels and increased risk of cardiovascular disorders. Conflicting data diverge on whether high leptin levels in climacterium reflect increasing adipose mass or, at least partially, age-related hormonal changes. This study addresses this issue in women from a Brazilian state with a low human development index. Subjects and methods A case-control study was conducted, enrolling 136 women from the state of Maranhão, 52 (38.2%) climacteric and 84 (61.8%) non-climacteric. Biometric, biochemical, hormonal and immunological parameters were analyzed. Results Climacteric women showed a moderately increased waist/hip ratio (0.894 versus 0.834, p < 0.05), sustained body mass index (27.46 versus 28.68, p > 0.05) increased leptin levels (9.59 versus 7.13, p < 0.05) and no evidence of metabolic syndrome. No other parameters were altered. The climacteric cohort didn’t show significant body fat gains but displayed a typical age-related redistribution of adipose tissue. Even so, leptin levels were significantly elevated compared with non-climacteric women. Conclusions Altogether, these data support the hypothesis that leptin is elevated, at least partially, as a function of age and climacterium and is not necessarily correlated with metabolic dysfunction and systemic inflammation. Further studies are needed to evaluate the impact of higher leptin levels on postmenopausal women. Arch Endocrinol Metab. 2020;64(3):276-81 |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000300276 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.20945/2359-3997000000249 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Archives of Endocrinology and Metabolism v.64 n.3 2020 reponame:Arquivos de Endocrinologia e Metabolismo (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
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SBEM |
reponame_str |
Arquivos de Endocrinologia e Metabolismo (Online) |
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Arquivos de Endocrinologia e Metabolismo (Online) |
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Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
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||aem.editorial.office@endocrino.org.br |
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